Results 81 to 90 of about 121,391 (261)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Building Capacity as Anchor Institutions: Infrastructure, Structure, and Strategy

Metropolitan Universities, 2019
As campuses embrace their role as anchor institutions, considerations should be given to the role of infrastructure, structure, and strategy. This article differentiates between infrastructure and organizational structure then identifies implications for
Kristin Elise Norris, H. Anne Weiss
doaj   +1 more source

Standartization of anchored retaining structures

Geotecnia, 1974
The pioneer developments of the anchored structures in the highway retaining walls in Brazil and in the world are discussed in this paper and some Brazilian examples are cited. The article also discusses the standartization of the permanent anchorages starting from that already adopted abroad, of the provisional anchorages, and the Brazilian standards ...
Nunes, A. J., Fonseca, Ana
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Development and Test of Internal-Cutting Down-Attached Anchor

Shiyou jixie
To solve the problems of low cutting efficiency and unstable cutting fracture quality caused by severe vibration and eccentric rotation of the cutter device in downhole hydraulic cutting operation of tubing and casing， a cutter down-attached anchor tool ...
Li Yong, Xu Zhendong, Wang Chenmin, Huang Jie, Zhang Xinping, Cao Jinkai, Kang Guirong   +6 more
doaj  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Inferring Anchor Links Based on Social Network Structure

IEEE Access, 2018
Nowadays, people usually participate in multiple social networks simultaneously, e.g., Facebook and Twitter. Formally, the correspondences of the accounts that belong to the same user are defined as anchor links, and the networks aligned by anchor links ...
Shuo Feng, Derong Shen, Tiezheng Nie, Yue Kou, Jingrui He, Ge Yu   +5 more
doaj   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Rock properties and adaptability of support structures in phosphorus mines: A case study of a phosphorus mine in Guizhou

Science Progress
Over-supporting and under-supporting of the roadway perimeter rock in the mining process will affect the support effect, so the existing roadway perimeter rock support needs to be analysed, and the support structure parameters need to be adjusted ...
Qinghe Lu, Zhen Lu, Ke Li, Zhenzhi Liu
doaj   +1 more source