Results 121 to 130 of about 332,158 (210)

Ensemble optimal control for managing drug resistance in cancer therapies [PDF]

open access: yesarXiv
In this paper, we explore the application of ensemble optimal control to derive enhanced strategies for pharmacological cancer treatment. In particular, we focus on moving beyond the classical clinical approach of giving the patient the maximal tolerated drug dose (MTD), which does not properly exploit the fight among sensitive and resistant cells for ...
arxiv  

Four novel mutations identification in 17 beta-hydroxysteroid dehydrogenase-3 deficiency and our clinical experience: possible benefits of early treatment

open access: yesFrontiers in Endocrinology
IntroductionIndividuals with 17-beta-hydroxysteroid dehydrogenase type 3 (17β-HSD3) deficiency face a multitude of challenges, primarily concerning genital appearance, potential malignancy risks, and fertility issues. This study reports our findings from
Yunpeng Wang   +22 more
doaj   +1 more source

Correlation between the presence of the nuclear AR-V7 androgen receptor and clinical evolution of prostate cancer: in vitro analysis of a combination of compounds targeting PI3K [PDF]

open access: yes, 2019
Introduzione: PCa è una malattia multiforme e biologicamente molto eterogenea. Diversi meccanismi chiave nella progressione della malattia da androgeno-dipendente ad androgeno-indipendente (CRCP) possono essere attribuiti ad alterazione nella via di ...
Cattarino, Susanna
core  

Application of topical minoxidil in acne vulgaris treatment

open access: yesDermatologica Sinica
Background: Acne vulgaris (AV) results from increased sebum production and Cutibacterium acnes (C. acnes) overgrowth, leading to pilosebaceous unit inflammation.
Chun-Bing Chen   +7 more
doaj   +1 more source

The Impact of TRPM8 on Prostate Cancer Transcriptomic Dynamics

open access: yesCells
Prostate cancer (PC) remains a significant health challenge, with androgen receptor (AR) signaling playing a pivotal role in its progression. This study investigates the expression and functional implications of the transient receptor potential ...
Swapna Asuthkar   +7 more
doaj   +1 more source

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