Results 91 to 100 of about 190,106 (204)

Profile of Relugolix in the Management of Advanced Hormone-Sensitive Prostate Cancer: Design, Development, and Place in Therapy

Drug Design, Development and Therapy, 2023
Tomoyuki Tatenuma,1,2 Hiroshi Miyamoto1,3 1Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA; 2Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan ...
Tatenuma T, Miyamoto H
doaj  

Effect of androgen treatment during foetal and/or neonatal life on ovarian function in prepubertal and adult rats [PDF]

, 2012
We investigated the effects of different windows of testosterone propionate (TP) treatment during foetal and neonatal life in female rats to determine whether and when excess androgen exposure would cause disruption of adult reproductive function ...
Alan S McNeilly, Amanda J Drake, Michelle Welsh, Broyde, Marie, Tyndall, Victoria, Welsh, M., McNeilly, Alan S, Drake, Amanda J, Victoria Tyndall, Richard Sharpe, Marie Broyde, Broyde, M., Welsh, Michelle, Sharpe, Richard, McNeilly, A.S., Drake, A.J., Sharpe, R., Tyndall, V.   +17 more
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Discovery of Novel Anti‐Resistance AR Antagonists Guided by Funnel Metadynamics Simulation

Advanced Science
Androgen receptor (AR) antagonists are widely used for the treatment of prostate cancer (PCa), but their therapeutic efficacy is usually compromised by the rapid emergence of drug resistance.
Haiyi Chen, Yuxin Zhou, Xinyue Wang, Xin Chai, Zhe Wang, Ercheng Wang, Lei Xu, Tingjun Hou, Dan Li, Mojie Duan   +9 more
doaj   +1 more source

Androgen deprivation induces double-null prostate cancer via aberrant nuclear export and ribosomal biogenesis through HGF and Wnt activation

Nature Communications
Androgen deprivation therapy (ADT) targeting androgen/androgen receptor (AR)- signaling pathways is the main therapy for advanced prostate cancer (PCa). However, ADT eventually fails in most patients who consequently develop castration-resistant prostate
Won Kyung Kim, Alyssa J. Buckley, Dong-Hoon Lee, Alex Hiroto, Christian H. Nenninger, Adam W. Olson, Jinhui Wang, Zhuo Li, Rajeev Vikram, Yao Mawulikplimi Adzavon, Tak-yu Yau, Yigang Bao, Michael Kahn, Joseph Geradts, Guang-Qian Xiao, Zijie Sun   +15 more
doaj   +1 more source

Development of Androgen Receptor Antagonists with Promising Activity in Castration-Resistant Prostate Cancer

, 2009
Androgen receptor (AR) continues to play a central role in prostate cancers that relapse after androgen deprivation therapy, but these tumors are refractory to available AR antagonists. In a recent issue of Science, Tran et al.
Shen, Howard C., Balk, Steven P.
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Characteristics and survival outcomes in patients with hormonosensitive metastatic prostate cancer in an oncologic centre in Medellín, Colombia

Medicina U.P.B.
Objective: To characterize patients with metastatic hormonesensitive prostate cancer (mHSPC) treated in an outpatient oncology care institution in Medellín-Colombia.Methods: An observational, retrospective study with survival analysis.
Diego Morán Ortiz, Camila Lema Calidonio, Daniel Efrén Rodríguez Ariza, Mauricio Lema Medina, Beatriz Elena Preciado Franco, Mateo Pineda Álvarez, Mauricio Luján Piedrahita   +6 more
doaj   +1 more source

Discovery of Aryloxy Tetramethylcyclobutanes as Novel Androgen Receptor Antagonists

, 2016
An aryloxy tetramethylcyclobutane was identified as a novel template for androgen receptor (AR) antagonists via cell-based high-throughput screening. Follow-up to the initial “hit” established 5 as a viable lead.
Jon Engebretsen (2148376), Javier Gonzalez (2025346), Samantha Greasley (2134057), Patrick Johnson (2148397), Martin Edwards (126755), Amina Zoubeidi (2148382), Wenyue Hu (799025), Paul Richardson (48962), Hiroaki Matsimoto (2148370), Chuangxing Guo (2148394), Toby Underwood (2148403), Andrew Morell (2148409), Hidetoshi Kuruma (2148379), Manli Shi (2148400), Robert Felstead (2148412), Martin Gleave (146446), Angelica Linton (2148373), Martha Ornelas (2148421), Gerrit Los (2148391), Hovik Gukasyan (2148418), Ping Kang (300222), Benjamin J. Burke (1309443), David Briere (2148415), Susan Kephart (2128099), Natilie Hosea (2148388), Asako Nagata (2128075), Mason Pairish (2039902), Andrea N. Fanjul (2148406), Kevin Dack (2148385)   +28 more
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TMPRSS2 Expression in Lung Tissue of Prostatic Adenocarcinoma Patients: Androgen Deprivation Therapy and Relevance to SARS-CoV-2 Infection

Current Issues in Molecular Biology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry is facilitated by transmembrane protease serine 2 (TMPRSS2), which is regulated by the androgen receptor (AR).
Marcela Riveros Angel, David Loeffler, Ahmad Charifa, Ryan B. Sinit, Taylor Amery, Beyza Cengiz, Tomasz M. Beer, George V. Thomas   +7 more
doaj   +1 more source

Binding of Clucocorticoid Antagonists To Androgen and Glucocorticoid Hormone Receptors in Rat Skeletal-muscle

, 1986
The binding of ten steroids possessing antiglucocorticoid activity has been studied in rat skeletal muscle cytosol. The affinity of these steroids for both the androgen and the glucocorticoid receptors was determined by competition with radioactive R1881
Rousseau, Guy, Danhaive, P A, Rousseau, GG., Danhaive, PA.   +3 more
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Steroid Hormones and Endocrine Disruptors: Recent Advances in Receptor–Mediated Actions [PDF]

, 2001
It has been accepted that receptor-mediated action of steroid hormones depends on both the receptor and the hormonal level. The mechanism of transcription by steroid receptors is mediated by cofactors, which function as co-activators or co-repressors,
Indarto, Dono, Izawa, Masao
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