Results 81 to 90 of about 190,106 (204)

Phosphorylation/Dephosphorylation of Androgen Receptor as a Determinant of Androgen Agonistic or Antagonistic Activity

Biochemical and Biophysical Research Communications, 1999
Protein phosphorylation/dephosphorylation is an important posttranslational modification that plays a critical role in signal transduction. The androgen receptor (AR) is under such control. We demonstrate that androgen receptor phosphorylation determines whether or not AR ligands perform as agonists or antagonists in LNCaP cells.
L G, Wang, X M, Liu, W, Kreis, D R, Budman   +3 more
openaire   +2 more sources

Progress in Clinical Research on Gonadotropin-Releasing Hormone Receptor Antagonists for the Treatment of Prostate Cancer

Drug Design, Development and Therapy, 2021
Yi-Fu Liu, Sheng-Qiang Fu, Yu-Chang Yan, Bin-Bin Gong, Wen-Jie Xie, Xiao-Rong Yang, Ting Sun, Ming Ma Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, 330000, Jiangxi Province, People’s Republic of ...
Liu YF, Fu SQ, Yan YC, Gong BB, Xie WJ, Yang XR, Sun T, Ma M   +7 more
doaj  

Sarcopenia and change in body composition following maximal androgen suppression with abiraterone in men with castration-resistant prostate cancer. [PDF]

, 2013
BACKGROUND: Standard medical castration reduces muscle mass. We sought to characterize body composition changes in men undergoing maximal androgen suppression with and without exogenous gluocorticoids.
J S de Bono, Pezaro, C., Cassidy, A.M., de Bono, J.S., Pezaro, C, Seed, G., Mukherji, D, de Bono, JS, Omlin, A, Tunariu, N., N Tunariu, G Attard, D Olmos, Attard, G, G Seed, Reid, A.H.M., Seed, G, Mukherji, D., A M Cassidy, Bianchini, D., Cassidy, AM, Olmos, D., A H M Reid, Attard, G., A Omlin, D Bianchini, D Mukherji, Tunariu, N, Olmos, D, Reid, AHM, C Pezaro, Bianchini, D, Omlin, A.   +32 more
core   +1 more source

Enhancing therapeutic efficacy in luminal androgen receptor triple-negative breast cancer: exploring chidamide and enzalutamide as a promising combination strategy

Cancer Cell International
Extensive exploration of the molecular subtypes of triple-negative breast cancer (TNBC) is critical for advancing precision medicine. Notably, the luminal androgen receptor (LAR) subtype has attracted attention for targeted treatment combining androgen ...
Ya-Xin Zhao, Han Wang, Si-Wei Zhang, Wei-Xin Zhang, Yi-Zhou Jiang, Zhi-Ming Shao   +5 more
doaj   +1 more source

Multidisciplinary Consensus on the Prevention and Treatment of Osteoporosis and Fragility Fractures in Patients with Prostate Cancer Receiving Androgen-Deprivation Therapy

The World Journal of Men's Health, 2022
Patients with prostate cancer (PCa) on androgen-deprivation therapy (ADT) are at high risk of osteoporosis and fragility fractures. We aimed to provide some practical insights into the delivery of optimal bone health care for PCa patients, particularly
Enrique Casado, Angel Borque-Fernando, Manuel Caamaño, Jenaro Graña, Jesús Muñoz-Rodríguez, Juan Morote   +5 more
doaj   +1 more source

Androgen Receptor

, 2018
The majority of physiological actions of testosterone and dihydrotestosterone are mediated by the androgen receptor, a member of the nuclear receptor superfamily, encoded as a single gene on the X-chromosome. Androgen receptor has four functional domains,
Smith, LB, McEwan, IJ, Lee B. Smith, Iain J. McEwan   +3 more
core   +1 more source

Anti-Müllerian hormone in PCOS: Molecular regulation and emerging therapeutic strategies

Biomolecules & Biomedicine
Anti-Müllerian hormone (AMH), a glycoprotein belonging to the transforming growth factor-beta (TGF-β) superfamily, is a key regulator of ovarian folliculogenesis.
Yunmei Ke, Dan Tang, Qin Yang, Han Zhao, Jinyan Zheng, Caifen Zhu   +5 more
doaj   +1 more source

Predictive factors for biochemical relapse in non-metastatic prostate cancer following primary radiotherapy

Medicinski Glasnik
Aim To investigate the predictors of biochemical relapse (BCR) among patients with non-metastatic prostate cancer treated with radiotherapy as the first-line therapy. Methods The study included 91 patients diagnosed with prostate cancer at the ...
Amila Kovčić, Šefika Umihanić, Hasan Osmić, Almedina Muhić, Enida Trumić, Eldar Hamzić, Emir Becirovic, Semir Hadžić, Amir Bećirović, Minela Becirovic, Emir Begagic   +10 more
doaj   +1 more source

Potent Androgen Antagonists Based on Carborane as a Hydrophobic Core Structure

, 2016
Carboranes (dicarba-closo-dodecaboranes) are a class of carbon-containing polyhedral boron-cluster compounds having remarkable chemical and thermal stability and hydrophobic character.
Tomoharu Suzuki (2677210), Shinya Fujii (565601), Shigeru Ohta (2472157), Yuichi Hashimoto (1665289), Tokuhito Goto (2677213), Yasuyuki Endo (401701), Kiminori Ohta (2246503)   +6 more
core   +1 more source

Comparison of combination therapy with tamsulosin and dutasteride or finasteride in patients with benign prostatic hyperplasia: a randomized clinical trial

African Journal of Urology
Background Based on our observations at the largest outpatient urology clinic in Iran, patients for whom finasteride is prescribed as a secondary drug to tamsulosin tend to experience earlier and more severe sexual side effects without any difference in ...
Abbas Basiri, Rasool Zare, Mazyar Zahir, Amir Hossein Kashi, Mahsa Zobeiry, Nasrin Borumandnia, Amir Reza Abedi, Shabnam Golshan   +7 more
doaj   +1 more source