Results 11 to 20 of about 19,533 (266)

Impacts of synthetic androgen and estrogenic antagonist administration on growth performance, sex steroids hormones, and immune markers of male and female broilers

Poultry Science, 2023
The influence of synthetic androgen and estrogenic antagonists (Tamoxifen) on body characteristics and immune response of male and female broilers and the correlation between sex hormone levels were estimated in our experiment.
Mona E.M. Younis, Fatima A. Jaber, Kamlah Ali Majrashi, Hanan A. Ghoneim, Mustafa Shukry, Manal E. Shafi, Najah M. Albaqami, Mohamed E. Abd El-Hack, Mahmoud M. Abo Ghanima   +8 more
doaj   +1 more source

Surgical stress delays prostate involution in mice. [PDF]

PLoS ONE, 2013
Androgens control growth of prostate epithelial cells and androgen deprivation induces apoptosis, leading to prostate involution. We investigated the effects of surgical stress on prostate involution induced by androgen ablation and determined the ...
Sazzad Hassan, Yelena Karpova, Anabel Flores, Ralph D'Agostino, George Kulik   +4 more
doaj   +1 more source

In silico prediction of nuclear receptor binding to polychlorinated dibenzofurans and its implication on endocrine disruption in humans and wildlife

Current Research in Toxicology, 2021
Polychlorinated dibenzofurans (PCDFs) are known to cause endocrine disruption in humans and wildlife but the mechanisms underlying this disruption have not been adequately investigated.
Lukman K. Akinola, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi   +3 more
doaj   +1 more source

Expanding armamentarium in advanced prostate cancer management: are all novel antiandrogens the same?

Prostate International, 2021
Prostate cancer (PCa) is the most common cancer in men. Androgen receptor axis plays a crucial role in the carcinogenesis of PCa. The mainstay treatment of prostate cancer is blockage of androgen receptor axis but in a vast majority of patient resistance
Emre Yekedüz, Güngör Utkan, Ravindran Kanesvaran, Yüksel Ürün   +3 more
doaj   +1 more source

Virtual Screening and Bioactivity Evaluation of Novel Androgen Receptor Antagonists From Anti-PCa Traditional Chinese Medicine Prescriptions

Frontiers in Chemistry, 2020
Prostate cancer (PCa), a type of malignancy that arises in the prostate gland, is the most commonly diagnosed neoplasm and the second leading cause of cancer-related deaths in men.
Wenya Han, Yuqi Shi, Jie Su, Zhennan Zhao, Xin Wang, Jiazhong Li, Huanxiang Liu   +6 more
doaj   +1 more source

Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19

iScience, 2021
Summary: Epidemiological data showing increased severity and mortality of COVID-19 in men suggests a potential role for androgen in SARS-CoV-2 infection.
Qu Deng, Reyaz ur Rasool, Ronnie M. Russell, Ramakrishnan Natesan, Irfan A. Asangani   +4 more
doaj   +1 more source

Androgen receptor antagonists for prostate cancer therapy [PDF]

Endocrine-Related Cancer, 2014
Androgen deprivation is the mainstay therapy for metastatic prostate cancer (PCa). Another way of suppressing androgen receptor (AR) signaling is via AR antagonists or antiandrogens. Despite being frequently prescribed in clinical practice, there is conflicting evidence concerning the role of AR antagonists in the management of PCa.
Christine, Helsen, Thomas, Van den Broeck, Arnout, Voet, Stefan, Prekovic, Hendrik, Van Poppel, Steven, Joniau, Frank, Claessens   +6 more
openaire   +2 more sources

MDM2 antagonists boost antitumor effect of androgen withdrawal: implications for therapy of prostate cancer

Molecular Cancer, 2011
Background Hormone therapy is the standard of care for newly diagnosed or recurrent prostate cancers. It uses anti-androgen agents, castration, or both to eliminate cancer promoting effect of testicular androgen. The p53 tumor suppressor controls a major
Packman Kathryn, Xia Mingxuan, Kolinsky Kenneth, Higgins Brian, Tovar Christian, Heimbrook David C, Vassilev Lyubomir T   +6 more
doaj   +1 more source

Endocrine disrupting potential of selected azole and organophosphorus pesticide products through suppressing the dimerization of human androgen receptor in genomic pathway

Ecotoxicology and Environmental Safety, 2022
Several pesticides widely used in agriculture have been considered to be endocrine disrupting chemicals through their binding affinities to estrogen or androgen receptors.
Da-Woon Jung, Da-Hyun Jeong, Hee-Seok Lee   +2 more
doaj   +1 more source

A-Norprogesterone, an Androgen Antagonist

Experimental Biology and Medicine, 1960
SummaryA-norprogesterone antagonizes testosterone induced accessory sex organ hypertrophy in the immature castrate male rat and comb growth stimulation in the chick. Growth of the ventral prostate, seminal vesicles, adrenals and thyroids of intact rats and the chick comb in animals not treated with androgen were significnatly reduced by administration ...
Lerner, L. J., Bianchi, A., Borman, A.
openaire   +2 more sources