Results 171 to 180 of about 41,661 (291)

5‐Hydroxytryptamine Distribution Alteration in Both Neuron and Synapse of Tg(SOD1*G93A)1gur Mice: A Potential Intervention Candidate Strategy for Amyotrophic Lateral Sclerosis

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This study reveals that 5‐hydroxytryptamine (5‐HT) synapses in the spinal cord and 5‐HT neurons in the brainstem of the SOD1‐G93A amyotrophic lateral sclerosis (ALS) mouse model are significantly altered, showing a decrease in pre‐symptomatic stages but a marked increase as the disease progresses.
Lijun Zhou, Menghua Li, Qi Dai, Xiwang Liu, Cheng Li, Huifeng Jiao, Haili Pan, Renshi Xu   +7 more
wiley   +1 more source

Androgen deprivation therapy and cognitive trajectories in Indian men: A 36-month prospective matched cohort analysis with Addenbrooke's cognitive examination-III. [PDF]

Indian J Urol
Gaurav G, Mishra S, Sengar APS, Lohani R, Kumar A, Amir M.   +5 more
europepmc   +1 more source

Lysine lactylation‐mediated post‐translational modification: Molecular mechanisms and therapeutic target exploration in tumour drug resistance

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Lysine lactylation (Kla) serves as a metabolic–epigenetic switch governed by writer–eraser–reader regulatory systems, directly connecting the Warburg effect to diverse forms of tumour drug resistance. Intratumoural lactylation critically contributes to treatment failure in chemotherapy, targeted therapy and immunotherapy.
Juan Li, Yan Shang, Haojie Wu, Shenglong Yang, Maiqun Zuo, Hailong Zhao   +5 more
wiley   +1 more source

Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
1. Lactate‐derived histone lactylation links glycolytic reprogramming to epigenetic regulation in female reproductive diseases. 2. In endometriosis, lactylation may promote inflammatory remodelling, immune dysregulation and ferroptosis resistance. 3. In PCOS, lactylation connects metabolic disturbance to granulosa‐cell dysfunction and hyperandrogenism.
Jiajun Qiao, Yue Xiao, Yi Cheng, Weihai Xu, Jing Shu, Shishi Li   +5 more
wiley   +1 more source

A Shot in the Dark: Unprecedented Complete Radiologic Response of Metastatic Prostate Cancer to Single-Dose Androgen Deprivation Therapy (ADT). [PDF]

Cureus
Deshpande RS, Ahluwalia P.
europepmc   +1 more source

Cost-effectiveness analysis of neoadjuvant docetaxel plus androgen deprivation therapy before radical prostatectomy in high-risk localized prostate cancer. [PDF]

Front Public Health
Liu Q, Wang Y, Yuan W, Chen J, Tian F, Zhan M, Guo M.   +6 more
europepmc   +1 more source

Cost-effectiveness of an artificial intelligence predictive model for guiding androgen deprivation therapy in intermediate-risk prostate cancer. [PDF]

JNCI Cancer Spectr
Courtney PT, Shih YT, Chang AJ, Lee A, Steinberg ML, Valle LF, Venkat PS, Kishan AU, Raldow AC.   +8 more
europepmc   +1 more source

Effectiveness and Safety of Interventions for Sarcopenia in Advanced Prostate Carcinoma: Systematic Review

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Sarcopenia has emerged as a potential prognostic factor in patients with advanced prostate cancer (PCa), requiring interventions for its prevention and treatment. Objective We aimed to systematically identify, critically assess and synthesize the available evidence on the effectiveness and safety of interventions for preventing or ...
Pedro de Pablos‐Rodríguez, Aythami de Armas‐Castellano, Diego Infante‐Ventura, Tasmania del Pino‐Sedeño, Antonio Rueda Domínguez, Pablo B. Pedrianes‐Martín, Jose A. L. Calbet, Pedro de Pablos‐Velasco, María M. Trujillo‐Martín   +8 more
wiley   +1 more source

Monitoring prostate cancer under androgen-deprivation therapy: insights from the implementation of a clinical decision support system dashboard. [PDF]

Front Oncol
Martínez-Pérez Á, Collantes G, Ruiz-Cerdá JL, Conde-Moreno A, Gironés R, Garcillán B, Amengual J, Gas ME.   +7 more
europepmc   +1 more source

Intermittent androgen deprivation therapy

The purpose of this study was to provide evidence-based recommendations of intermittent androgen deprivation therapy (IADT) compared with continuous androgen deprivation therapy (CADT) for men with prostate cancer (PCA). We conducted a comprehensive search in MEDLINE, EMBASE, The Cochrane Library, CINAHL, and ECONLIT, from the database inception to ...
Bonfill, X. (Xavier)||, Arevalo-Rodriguez, Ingrid||, Martínez García, Laura||, Quintana Ruiz, Maria Jesús||, Buitrago-Garcia, Diana||, Lobos Urbina, D., Cordero, José Antonio||   +6 more
openaire   +1 more source