Results 131 to 140 of about 204,414 (356)

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Androgen receptor in relation to progesterone receptor (AR/PR ratio) in non-metastatic hormonal positive, Her2neu negative breast cancer

SVU - International Journal of Medical Sciences
Background: The impact of estrogen/progesterone receptors (ER/PR) is well-established with respect to therapy and prognosis of breast carcinoma. However, the role of androgen receptor (AR) expression is varying among breast cancer subtypes.
Maged A.F. Amine , Ahmed Mubarak Hefni , Shimaa R. Younis*, Tarek M Elsaba , Amen H. Zaky , Ashraf Zedan   +5 more
doaj   +1 more source

Molecular Defects of the Androgen Receptor

Recent Progress in Hormone Research, 1999
Defects of the androgen receptor cause a wide spectrum of abnormalities of phenotypic male development, ranging from individuals with mild defects of virilization to those with complete female phenotypes. In parallel with this phenotypic spectrum, a large number of different mutations have been identified that alter the synthesis or functional activity
openaire   +4 more sources

Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor

Cancer Communications, EarlyView.
Abstract Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. However, their functional importance in disease progression has often been underestimated due to their ...
Wenpeng Cai, Tao Fan, Chu Xiao, Ziqin Deng, Yixiao Liu, Chunxiang Li, Jie He   +6 more
wiley   +1 more source

Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer

Nature Communications, 2016
Castration-resistant prostate cancer frequently presents with persistent androgen receptor signalling. Here, the authors find that the androgen receptor is subject to genetic rearrangements, resulting in variants with ligand-independent activity.
Christine Henzler, Yingming Li, Rendong Yang, Terri McBride, Yeung Ho, Cynthia Sprenger, Gang Liu, Ilsa Coleman, Bryce Lakely, Rui Li, Shihong Ma, Sean R. Landman, Vipin Kumar, Tae Hyun Hwang, Ganesh V. Raj, Celestia S. Higano, Colm Morrissey, Peter S. Nelson, Stephen R. Plymate, Scott M. Dehm   +19 more
doaj   +1 more source

Androgen and estrogen receptors in hepatocellular carcinoma and in the surrounding noncancerous liver tissue [PDF]

, 1986
S. Tsuyoshi Ohnishi, Tohru Murakami, Takashi Moriyama, Keiji Mitamura, Michio Imawari   +4 more
openalex   +1 more source

Evaluation of Polar Substituted Schiff Bases and 1,2,3‐Triazole Hybrids as Anticancer Agents

Chemistry &Biodiversity, EarlyView.
ABSTRACT Polar substituted Schiff bases and 1,2,3‐triazole hybrids (2–6) were successfully synthesized by Schiff base condensation reaction between the previously synthesized triazole 1 and series of polar substituted amines. The chemical structures of the hybrids were confirmed using spectroscopies (NMR and FTIR), CHN elemental analysis and single ...
Yonas Belay, Alfred Muller, Sage Singh, Adedapo S. Adeyinka, Lesetja R. Motadi, Abel K. Oyebamiji   +5 more
wiley   +1 more source

Hijacking the MDM2 E3 Ligase with Novel BRD4‐Targeting Proteolysis‐Targeting Chimeras in Pancreatic Cancer Cells

ChemBioChem, EarlyView.
The discovery of novel ligands recruiting less explored E3 ligases remains challenging. Herein, the discovery of a novel Mouse double minute 2‐recruiting Proteolysis‐Targeting Chimera is reported, which shows preferential degradation of the Bromodomain‐containing protein 4 short isoform (BRD4 S) and c‐Myc compared with MZ1, a validated Von‐Hippel ...
Mihaela P. Ficu, Dan Niculescu‐Duvaz, Mohammed Aljarah, Christopher S. Kershaw, Caroline J. Springer   +4 more
wiley   +1 more source

Androgen receptor dysfunction in human androgen insensitivity

Trends in Endocrinology & Metabolism, 1995
The androgen insensitivity syndromes comprise a spectrum of phenotypic abnormalities in male sex differentiation and development that result from target tissue resistance to androgen action due to molecular lesions in the X-chromosome-linked androgen receptor gene.
openaire   +3 more sources

Modular Synthesis of Unsymmetrical 1,1’‐Disubstituted Ferrocenes by Sequential Suzuki‐Miyaura Cross‐Coupling of 1,1’‐Diborylferrocene

Chemistry – A European Journal, EarlyView.
A facile synthesis of unsymmetrical 1,1’‐disubstituted ferrocene derivatives based on the desymmetrization of 1,1’‐diborylferrocene was developed. Suzuki‐Miyaura cross‐coupling (SMCC) reaction of 1,1’‐diborylferrocene afforded mono‐substituted products without significant loss of the second boryl group, and the subsequent second SMCC reaction afforded ...
Kotaro Ochiai, Ryo Yonezawa, Shinya Fujii   +2 more
wiley   +1 more source