Results 151 to 160 of about 1,391,256 (255)

Cardiac function in zebrafish embryos is linked to an androgen receptor-adrenomedullin-proepicardium axis. [PDF]

Cell Commun Signal
Duong Phu M, Guerrero Samanidis A, Laibacher S, Burczyk M, Alkhars Y, Janovic A, Al Madhoun A, Skerjanc IS, Burkhalter MD, Philipp M.   +9 more
europepmc   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Androgen receptor drives divergent chromatin accessibility programs in benign and malignant prostate epithelial cells. [PDF]

Nucleic Acids Res
Kukkonen K, Afyounian E, Rauhala H, Nykter M, Urbanucci A, Latonen L, Visakorpi T.   +6 more
europepmc   +1 more source

Toxic Effects of Bisphenol A and Its Analogs on Ovarian Structure and Function: A Narrative Review of Ovary‐Focused Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin, Marwa Tawfıq Ahmed Alsalım, Muhammed Canik, Sevda Bağdatlı, Nazan Deniz Yön   +4 more
wiley   +1 more source

Drugging the intrinsically disordered transactivation domain of androgen receptor. [PDF]

Signal Transduct Target Ther
Obst JK, Banuelos CA, Jian K, Tien AH, Shkrabak OA, Wang J, Mawji NR, Tam T, Vuckovic M, Williams DE, Rogalski JC, Yuan X, Strynadka NCJ, Andersen RJ, Sadar MD.   +14 more
europepmc   +1 more source

Low‐Dose Chlorothalonil Induces Testicular Injury Through Disruption of Steroidogenic Signaling in Adult Male Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Chlorothalonil (CHL) is a widely used organochlorine fungicide frequently detected in environmental and food matrices. Although increasing evidence indicates adverse effects in nontarget species, the mechanisms underlying CHL‐induced male reproductive toxicity remain incompletely understood.
Cristiana Livramento Oliveira Pinto, Nicoly Caixêta Gonçalves, Paula Rafaela Queiroz da Silva, Ludmila Rodrigues Pontes, Juliana Reis Machado, Virmondes Rodrigues Jr., Hugo Felix Perini, Gláucia Eloisa Munhoz de Lion Siervo   +7 more
wiley   +1 more source

Androgen receptor imprints satellite cell stemness and preserves their reservoir for lifelong regeneration and optimal repair. [PDF]

Sci Adv
Rizk JG, Ghaibour KC, Souali-Crespo S, Calvano E, Bilger A, Jacobs H, Messaddeq N, Cai Q, Grangirard E, Sahu R, Ferry A, Fourcade V, Zoll J, Zanardelli G, Molina N, Fontaine C, Arnal JF, Metzger D, Duteil D.   +18 more
europepmc   +1 more source

Potential Neuroendocrine Disruption by Benzodiazepines and Its Impact on Male Fertility

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neuroactive substances have emerged as potent endocrine disruptors affecting male reproductive health through central and peripheral mechanisms. Among these, benzodiazepines, which are widely used for the management of anxiety, insomnia, epilepsy, and neuromuscular disorders, are known as GABA A (gamma‐aminobutyric acid type A) receptor ...
Ana Clara Melo Andrade de Rodrigues, Julia Gonçalves Rodrigues, Marcos de Lucca Moreira Gomes, Fernanda Carolina Ribeiro Dias   +3 more
wiley   +1 more source

SPEN inactivation drives resistance to androgen receptor pathway inhibitors in metastatic prostate cancer. [PDF]

Clin Cancer Res
Blinka S, Arora S, Rudoy D, Gowda A, Yong P, Hwang Y, Nyquist MD, Graf R, Li G, Nelson PS, Schweizer MT, Hsieh AC.   +11 more
europepmc   +1 more source

Bisphenol M Induces Dose‐Dependent Hepatic Injury and Fibrotic Remodeling in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The safety of bisphenol analogs as alternatives to bisphenol A (BPA) is increasingly concerning. This study investigated the hepatotoxic effects of bisphenol M (BPM), a widely used BPA substitute, in 6‐week‐old female BALB/c mice exposed to 2.5, 5, and 10 mg/kg/day intraperitoneally for 14 days. Hepatic changes were assessed via histopathology,
Muhammed Canik, Asuman Deveci Ozkan, Tuğba Kotil, Nazan Deniz Yön   +3 more
wiley   +1 more source