Results 161 to 170 of about 113,908 (219)

UGT2B15 Acts as a Critical Detoxification Barrier Against Chemi-Cal-Induced Hepatotoxicity and Carcinogenesis via the Androgen Receptor Axis. [PDF]

Cells
Zhao Y, Wang Y, Li Y, Liu S, Jia Z, Wang Y, Zhang R, Liu Z, Lu L.   +8 more
europepmc   +1 more source

Quercetin Inhibits AKT Ser473 Phosphorylation and Disrupts AKT-Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Cells. [PDF]

Antioxidants (Basel)
Duprat F, Azócar-Plaza S, Castillo-Cáceres MP, Rivas Y, Sanzana-Rosas J, Pampaloni P, Olivas-Henríquez G, Toledo J, Villa JL, Bertinat R, Jara N, Vallejos-Almirall A, Salas A, González-Chavarría I.   +13 more
europepmc   +1 more source

Experimental peptides, GLP‐1s and polypharmacy: Future directions for image‐ and performance‐enhancing drug harm reduction

Addiction, EarlyView.
Luke A. Turnock, Lambros Lazuras
wiley   +1 more source

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The androgen receptor

2023
The Androgen Receptor (AR) is a ligand (androgen) activated transcription factor and a member of the nuclear receptor (NR) superfamily. It is required for male sex hormone function. AR-FL (full-length) has the domain structure of NRs, an N-terminal domain (NTD) required for transactivation, a DNA-binding domain (DBD), a nuclear localization signal (NLS)
Greg, Van-Duyne, Ian A, Blair, Cynthia, Sprenger, Vera, Moiseenkova-Bell, Stephen, Plymate, Trevor M, Penning   +5 more
openaire   +2 more sources

Androgens and androgen receptors in breast cancer

The Journal of Steroid Biochemistry and Molecular Biology, 2007
Aromatase (CYP19) converts adrenal and ovarian androgens into estrogens, which supports the growth of estrogen-dependent breast cancers. Anti-aromatase agents are displacing antiestrogens as the first-line treatment for estrogen receptor positive breast cancers.
B, Nicolás Díaz-Chico, F, Germán Rodríguez, Ana, González, Raquel, Ramírez, Cristina, Bilbao, A, Cabrera de León, A, Aguirre Jaime, Ricardo, Chirino, Domingo, Navarro, Juan C, Díaz-Chico   +9 more
openaire   +2 more sources

Testosterone and the Androgen Receptor

Urologic Clinics of North America, 2022
Testosterone is a steroid hormone that is responsible for the development of normal male sexual characteristics and function as well as the maintenance of homeostasis among multiple organ systems throughout life. Testosterone production is regulated by the hypothalamic-pituitary axis under the direction of gonadotropin-releasing hormone and luteinizing
Thomas, Gerald, Ganesh, Raj
openaire   +2 more sources

Androgens, Antiandrogens and Androgen Receptor Abnormalities

European Urology, 1996
Information on the molecular structure of the human androgen receptor has increased insight into the molecular mechanism of action of androgens and antiandrogens. It has also facilitated the study of molecular defects in the androgen receptor gene associated with prostate cancer.
C W, Kuil, A O, Brinkmann
openaire   +2 more sources