Results 171 to 180 of about 1,391,256 (255)

Synthesis of Enantiospecific Androgen Receptor Antagonists of Enzalutamide-Resistant Human Prostate Cancer Cells. [PDF]

ACS Med Chem Lett
Liu C, Sun Y, Myat Thwe P, Harter GA, Chilakala S, Katz JE, Canfield E, Zapotoczny G, Haliday B, Elton E, Kashemirov BA, Patsch K, Agus DB, McKenna CE.   +13 more
europepmc   +1 more source

Risk Factors Influencing Efficacy and Prognosis Evaluation of Neoadjuvant Systemic Therapy in Triple‐Positive Breast Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT To identify the determinants of the response to neoadjuvant systemic therapy (NST) in triple‐positive breast cancer (TPBC), we retrospectively enrolled 520 patients with human epidermal growth factor receptor 2 (HER2)‐positive breast cancer who were treated at The First Affiliated Hospital of Chongqing Medical University between January 2015 ...
Lin‐Rui Miao, Hao Liu, Hai‐Ying Yu, Jian Chen, Ming‐Yu Yang, Ya‐Lan Zhang, Gang Tu, Ling‐Feng Tang   +7 more
wiley   +1 more source

Phosphorylation of androgen receptor dictates protein-protein interactions and function

reservedThe androgen receptor (AR) is a member of the steroid hormone group of nuclear receptors (NRs) and the main mediator of androgen signalling. Encoded by the AR gene on the X chromosome, AR is a transcription factor involved in biological functions
MENNA, ANGELA
core  

Kaiso modulates androgen receptor expression in triple-negative breast cancer. [PDF]

Breast Cancer Res
Ali Fairbairn S, Kim K, Cowan RW, Lessey LR, Fanaian M, Adan H, Golamari S, Rattan R, Daniel JM.   +8 more
europepmc   +1 more source

Bipolar Androgen Therapy as a Potential Mechanistic Bridge to Enhance PARP Inhibitor Efficacy in Prostate Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Prostate cancer remains a leading cause of cancer‐related mortality, largely driven by progression to metastatic castration‐resistant prostate cancer (mCRPC). Although poly(ADP‐ribose) polymerase inhibitors (PARPis) have improved outcomes in patients with homologous recombination repair (HRR) alterations, particularly in BRCA2‐mutated disease,
Jhen‐Hao Jhan, Jiun‐Hung Geng, Hung‐Lung Ke, Shu‐Pin Huang, Li Jia   +4 more
wiley   +1 more source

Androgen Receptor-Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis. [PDF]

Adv Sci (Weinh)
Liu C, Peng Q, Zhang X, Li Z, Wu Y, Wen Y, Zheng R, Wu S, Zhou C, Hu Z, Shu L, Ma X, Li Q, Ma Y, Ou C, Zhao M, Fan S, Wei L, Ma J.   +18 more
europepmc   +1 more source

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source

Prenatal Androgenization Modifies H3K9me3 Binding in the Promoter of the Androgen Receptor Gene in the Arcuate Nucleus of the Adult Female Mouse. [PDF]

Reprod Sci
Watanabe Y, Glendining KA, Fisher L, Campbell RE, Jasoni CL.   +4 more
europepmc   +1 more source

COVID‐19 Amplifies Sex‐Specific Dopamine and Glial Responses in a Parkinson's Disease Mouse Model

Movement Disorders, EarlyView.
Abstract Background Exposure to environmental agents, including viral infections, may increase Parkinson's disease (PD) susceptibility, especially in males, but the neurodegenerative risk extent of COVID‐19 remains uncertain. Objectives We investigated the plausible link between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and
Ifeoluwa Awogbindin, Mélanie Bourque, Marc Morissette, Marie‐Ève Hamelin, Chantal Rhéaume, Jared VanderZwaag, Antonia Landwehr, Disha Patel, Guy Boivin, Marie‐Ève Tremblay, Thérèse Di Paolo   +10 more
wiley   +1 more source

Testosterone and androgen receptor pathway modulation in sepsis: immunometabolic mechanisms and therapeutic implications - a scoping review. [PDF]

Front Endocrinol (Lausanne)
Szczupak M, Kobak J, Kreczko M, Wierzchowska J, Krupa-Nurcek S.   +4 more
europepmc   +1 more source