Results 151 to 160 of about 230,623 (311)

Screening anticancer peptides performance in organotypic prostate tumor‐stroma 3D models

International Journal of Cancer, EarlyView.
What's New? Peptide‐based drugs have emerged as promising anticancer therapies for their potential to disrupt protein–protein interactions. In this study, the authors developed a physiomimetic human 3D prostate cancer spheroid model to assess the efficacy of the CAVPENET peptide in inhibiting tumor growth. Upon incubation with CAVPENET, prostate cancer
Bárbara Matos, Maria V. Monteiro, Matilde R. Lagarto, John Howl, Carmen Jerónimo, Vítor M. Gaspar, João F. Mano, Margarida Fardilha   +7 more
wiley   +1 more source

A review of the impact of micro‐ and nanoplastics on female reproduction: What we know and gaps in knowledge

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Micro‐and nanoplastics (MNPs) are breakdown products of plastics, and humans are exposed to these particles through air, water, food, and soil. There is a growing concern that human exposure to MNPs negatively impacts health. In this review we will discuss the potential health impact of MNPs on ovarian function and the hypothalamic–pituitary ...
Sanchayana Raghuvir, Shawn Alex, Deborah Clegg   +2 more
wiley   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

A Novel Androgen Receptor Splice Variant Is Up-regulated during Prostate Cancer Progression and Promotes Androgen Depletion–Resistant Growth [PDF]

, 2009
Zhiyong Guo, Xi Yang, Feng Sun, Richeng Jiang, Douglas E. Linn, Hege Chen, Hegang Chen, Xiangtian Kong, Jonathan Melamed, Clifford G. Tepper, Hsing-Jien Kung, Angela Brodie, Joanne Edwards, Yun Qiu   +13 more
openalex   +1 more source

Supplementary Tables S1-S5 from NKX3.1 Suppresses <i>TMPRSS2–ERG</i> Gene Rearrangement and Mediates Repair of Androgen Receptor–Induced DNA Damage [PDF]

, 2023
Cai Bowen, Tian Zheng, Edward P. Gelmann
openalex   +1 more source

Evaluating the Endocrine‐Disrupting and Oxidative Stress Potential of a 50‐Component Human‐Relevant Complex Chemical Mixture Using In Vitro Tests

Journal of Applied Toxicology, EarlyView.
ABSTRACT Humans are chronically exposed to mixtures of environmental contaminants. Exposure to endocrine‐disrupting chemicals (EDCs) contributes to increased health impairment observed globally. This study aimed to evaluate the endocrine‐disruptive and oxidative stress potential of a human‐relevant, complex chemical mixture in vitro.
Josefin Engelhardt, Nathalie Struwe, Annika Jansson, Vesna Munic Kos, Maria Larsson, Jana M. Weiss   +5 more
wiley   +1 more source

Potential endocrine-disrupting effects of iprodione via estrogen and androgen receptors: evaluation using in vitro assay and an in silico model

Applied Biological Chemistry
This study was conducted to provide evidence, using in vitro and in silico testing methods, regarding the adverse effects of iprodione, a representative dichlorophenyl dicarboxamide fungicide, on the endocrine system.
Ji-Yeon Yang, Jeong-Hyun Lim, Soo-Jin Park, Youmi Jo, Si Young Yang, Min-Kyoung Paik, So-Hye Hong   +6 more
doaj   +1 more source

MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1α/HIF-1β [PDF]

, 2010
Paul D. Cao, Zhiyong Deng, Meimei Wan, Weiwei Huang, Scott D. Cramer, Jianfeng Xu, Ming Lei, Guangchao Sui   +7 more
openalex   +1 more source

Small Nucleotide Variant Analysis Using RNA Fusion Panel (SMURF): Making the Most of RNAseq Data in Solid Tumours

Journal of Clinical Laboratory Analysis, EarlyView.
RNA‐based fusion panels using targeted next‐generation sequencing of formalin‐fixed paraffin‐embedded (FFPE) tumour tissue specimens have been used for a few years from patients with various tumour types to detect rearrangements/fusions. Using the bioinformatic approaches the data obtained from RNA sequencing (RNAseq) can also be used for small ...
Pranav Dorwal, Julie Robin, Broden Krause, Patricia Pyrchla, Bin Yuan, Robert Quach, Anna Fong Na Goh, Pamela Htain, Noel Djitro, Amit Kumar, Liyan Song, Priscillia Siswara, Suzanne Svobodova, Peter Kaub, Beena Kumar   +14 more
wiley   +1 more source