Results 201 to 210 of about 210,919 (300)

Identification of a Novel Trifluoromethyl-Bearing Flavonoid as a Promising Androgen Receptor Antagonist: Structure-Based Virtual Screening and In Vitro Study. [PDF]

Comput Struct Biotechnol J
Tadasee P, Khotavivattana T, Chaithirayanon K, Assawakosri S, Nutho B.   +4 more
europepmc   +1 more source

One‐year follow‐up after fractionated ultra‐high‐dose‐rate FLASH radiotherapy in patient with extramammary Paget disease of the scrotum

Precision Radiation Oncology, EarlyView.
An elderly male patient with extramammary Paget disease of the scrotum and multiple metastases was treated with fractionated FLASH‐RT (40 Gy in 5 fractions) in the scrotal lesion. Abstract Objective Ultrahigh‐dose‐rate radiotherapy (FLASH‐RT) has been shown to reduce radiation‐induced normal tissue injury in preclinical studies.
Hui Luo, Chengliang Yang, Ronghu Mao, Leijie Ma, Hongchang Lei, Peng Chen, Yanping Zhang, Meng Xu, Chao Wang, Yiwu Wang, Mingxia Wu, Chanjun Sun, Han Liu, Hui Liu, Hong Ge   +14 more
wiley   +1 more source

Impact of Genomic Mutations on the Transcriptional Pathways and Tumor Microenvironment Landscape of Localized Early Prostate Cancer

The Prostate, EarlyView.
ABSTRACT Background The management of intermediate‐risk early prostate cancer (PCa) is challenging due to the difficulty in distinguishing indolent from aggressive tumors. This study explores the association between genomic alterations and the tumor and its microenvironment (TME) and implications for disease progression. Methods We performed multi‐omic
William Lautert‐Dutra, Camila M. Melo, Luiz P. Chaves, Francisco C. Souza, Vida Talebian, Cheryl Crozier, Mary Anne Quintayo, Linda Liao, Dan Dion, Fabiano P. Saggioro, Felipe S. Avante, Rodolfo B. dos Reis, Jeremy A. Squire, Jane Bayani   +13 more
wiley   +1 more source

Assessing the prognostic role of androgen receptor expression in non-metastatic triple-negative breast cancer. [PDF]

Front Oncol
Al-Masri M, Safi Y, Aljalabneh B, Jarah I, Ananzeh H, AlMasri R, Alayyan O, Alawneh F, Almasri M.   +8 more
europepmc   +1 more source

Non‐Cancer Causes of Death in Patients With Metastatic Hormone‐Sensitive Prostate Cancer: A Real‐World Analysis

The Prostate, EarlyView.
ABSTRACT Background As overall survival improves in metastatic hormone‐sensitive prostate cancer (mHSPC), non‐cancer causes of death are increasingly relevant. Methods We conducted a real‐world multicenter study of patients diagnosed with mHSPC treated with ADT alone or in combination. Causes of death before progression to castration‐resistant prostate
Marta Garcia de Herreros, Clara Rodrigo, Laura Ferrer‐Mileo, Laia Fernández‐Mañas, Joel Mases, Nely Diaz, Antoni Vilaseca, Mariana Altamirano, Roser Gibanel, Maria José Ribal, Natalia Jimenez, Oscar Reig, Mariona Figols, Miguel Ángel Climent, Albert Font, Begoña Mellado   +15 more
wiley   +1 more source

Selective androgen receptor modulators: a critical appraisal. [PDF]

Front Endocrinol (Lausanne)
Bond P, Smit DL, Verdegaal T, de Ronde W.   +3 more
europepmc   +1 more source

Castration Resistance Accelerates Prostate Cancer Kinetics

The Prostate, EarlyView.
ABSTRACT Background Prostate cancer can be an indolent disease with which patients can live for many years. Thus, an understanding of how therapy and its ensuing resistance affect prostate cancer kinetics may guide efforts to determine optimal timing of therapy initiation.
Sheila Jonnatan, Luka Cavka, Angelo M. De Marzo, Samuel R. Denmeade, Mark C. Markowski, Emmanuel S. Antonarakis, Bruce J. Trock, Catherine H. Marshall, Ravi A. Madan, David J. Einstein, Laura A. Sena   +10 more
wiley   +1 more source

Brief Report: Androgen Receptor Expression Is Associated With Male Predominance in Thymic Neuroendocrine Neoplasms. [PDF]

JTO Clin Res Rep
Nabel CS, Sussman CB, Whittaker CA, Butty VL, Peterson JL, Martin HK, Louissaint A, Bru-Tari E, Chera S, Ligon AH, Yeap BY, Herrera PL, Hung YP.   +12 more
europepmc   +1 more source

Mapping the Radiopharmaceutical Therapy Landscape for Prostate Cancer: Insights Into Global Clinical Trial Trends and Future Directions

Med Research, EarlyView.
Zhiwu Dong, Sixiang Yan, Xiaodong Liu, Peng Gu   +3 more
wiley   +1 more source

Temporal Patterns and Resolution of Toxicities Following Hypofractionated Salvage Radiotherapy for Biochemical Recurrence of Prostate Cancer After Prostatectomy

The Prostate, EarlyView.
ABSTRACT Background Hypofractionated salvage radiotherapy is increasingly used for biochemical recurrence of prostate cancer post‐prostatectomy, yet its toxicity profile remains underexplored. This study evaluates the incidence, timing, and resolution of treatment‐related toxicities in this setting.
Bum‐Sup Jang, Seok‐Joo Chun, Jin Ho Kim   +2 more
wiley   +1 more source