Results 31 to 40 of about 230,623 (311)

In silico prediction of nuclear receptor binding to polychlorinated dibenzofurans and its implication on endocrine disruption in humans and wildlife

Current Research in Toxicology, 2021
Polychlorinated dibenzofurans (PCDFs) are known to cause endocrine disruption in humans and wildlife but the mechanisms underlying this disruption have not been adequately investigated.
Lukman K. Akinola, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi   +3 more
doaj   +1 more source

Negative regulation of the androgen receptor gene through a primate specific androgen response element present in the 5' UTR [PDF]

, 2014
Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Hay, Colin W, Hunter, Irene, Lavery, Derek N, MacKenzie, Alasdair, McEwan, Iain J, Watt, Kate   +5 more
core   +2 more sources

Severe forms of partial androgen insensitivity syndrome due to p.L830F novel mutation in androgen receptor gene in a Brazilian family

BMC Research Notes, 2011
Background The androgen insensitivity syndrome may cause developmental failure of normal male external genitalia in individuals with 46,XY karyotype.
Guerra-Junior Gil, de Calais Flávia L, Soardi Fernanda C, Maciel-Guerra Andréa T, Petroli Reginaldo J, de Mello Maricilda   +5 more
doaj   +1 more source

Androgen receptor phosphorylation status at serine 578 predicts poor outcome in prostate cancer patients [PDF]

, 2016
Purpose: Prostate cancer growth is dependent upon androgen receptor (AR) activation, regulated via phosphorylation. Protein kinase C (PKC) is one kinase that can mediate AR phosphorylation. This study aimed to establish if AR phosphorylation by PKC is of
Edwards, J., Heng, J.S., Horgan, P.G., Leung, H.Y., Patek, S.C., Taylor, B., Underwood, M.A., Willder, J.M.   +7 more
core   +1 more source

The impact of point mutations in the human androgen receptor: classification of mutations on the basis of transcriptional activity.

PLoS ONE, 2012
Androgen receptor mediated signaling drives prostate cancer cell growth and survival. Mutations within the receptor occur infrequently in prostate cancer prior to hormonal therapy but become prevalent in incurable androgen independent and metastatic ...
Colin W Hay, Iain J McEwan
doaj   +1 more source

Research Progress of Androgen/Androgen Receptor Signaling Pathway in Hepatocellular Carcinoma

Zhongliu Fangzhi Yanjiu, 2023
Hepatocellular carcinoma (HCC) is a kind of primary liver cancer with a high mortality rate. In China, the incidence ratio in males to females with HCC is 2:1–5:1.
WANG Ruihua, CAI Shiliang, LIU Donghong, CHEN Hongsen, CAO Guangwen   +4 more
doaj   +1 more source

Androgen receptor phosphorylation at serine 515 by Cdk1 predicts biochemical relapse in prostate cancer patients [PDF]

, 2013
<br>Background:Prostate cancer cell growth is dependent upon androgen receptor (AR) activation, which is regulated by specific kinases. The aim of the current study is to establish if AR phosphorylation by Cdk1 or ERK1/2 is of prognostic ...
BV Kallakury, C E Adams, C Tannahill, D Gioeli, D Gioeli, G Fyffe, GG Kuiper, H Y Leung, H Zong, HY Wong, J Edwards, J Ferlay, J M Willder, JC Obenauer, JS Diallo, K Shigemura, KS McCarty, LA Ponguta, LJ Blok, M A Underwood, M Mistry, M Roach, M Seywright, MS Cookson, NG Anderson, P Chymkowitch, P G Horgan, P McCall, R Mukherjee, RE Bakin, RK Tyagi, S Chen, S Chen, S J Heng, SM Powell, T Kirkegaard, T Ohta, WC Bell, Y Wen, Z Fu, ZX Zhou   +40 more
core   +1 more source

Therapeutic potential of TRPM8 antagonists in prostate cancer

Scientific Reports, 2021
Transient receptor potential melastatin-8 (TRPM8) represents an emerging target in prostate cancer, although its mechanism of action remains unclear.
Marzia Di Donato, Carmine Ostacolo, Pia Giovannelli, Veronica Di Sarno, Isabel M. Gomez Monterrey, Pietro Campiglia, Antimo Migliaccio, Alessia Bertamino, Gabriella Castoria   +8 more
doaj   +1 more source

The epigenetic function of androgen receptor in prostate cancer progression

Frontiers in Cell and Developmental Biology, 2023
Androgen and androgen deprivation (castration) therapies, including androgen receptor antagonists, are clinically used to treat patients with prostate cancer.
Takahiro Sawada, Takahiro Sawada, Yoshiaki Kanemoto, Yoshiaki Kanemoto, Tomohiro Kurokawa, Tomohiro Kurokawa, Tomohiro Kurokawa, Shigeaki Kato, Shigeaki Kato, Shigeaki Kato   +9 more
doaj   +1 more source

Testosterone Influence on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome [PDF]

, 2019
Purpose: Sjögren syndrome is an autoimmune disorder that occurs almost exclusively in women and is associated with extensive inflammation in lacrimal tissue, an immune-mediated destruction and/or dysfunction of glandular epithelial cells, and a ...
Kam, Wendy R., Lieberman, Scott M., Morthen, Mathias Kaurstad, Rahimi Darabad, Raheleh, Richards, Stephen M., Sullivan, David A., Tellefsen, Sara   +6 more
core   +1 more source