Results 41 to 50 of about 110,485 (214)
Pre-receptor regulation of the androgen receptor [PDF]
Molecular and Cellular Endocrinology, 2008 The human androgen receptor (AR) is a ligand-activated nuclear transcription factor and mediates the induction of genes involved in the development of the male phenotype and male secondary sex characteristics, as well as the normal and abnormal growth of the prostate.
Trevor M. Penning +3 more
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Biomolecules, 2021 The androgen receptor (AR) is one of the main components in the development and progression of prostate cancer (PCa), and treatment strategies are mostly directed toward manipulation of the AR pathway.
Tae Jin Kim, Young Hwa Lee, Kyo Chul Koo
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Prostate CancerThis study evaluated the effects of docetaxel and androgen receptor signaling inhibitors as second-line treatments in patients with castration-resistant prostate cancer after androgen receptor signaling inhibitors as first-line treatment.
Kazuro Kikkawa +7 more
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Molecular Modeling Studies of Natural Inhibitors of Androgen Signaling in Prostate Cancer
Cancer Informatics, 2022 Prostate cancer is the second most common disease in men and the sixth leading cause of death from cancer globally, with 20 million men expected to be affected by 2024 thus considered as chronic illness which requires immediate attention.
Samuel O Olubode +8 more
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Neural Regeneration ResearchSpinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene, which encodes a ligand-dependent transcription factor.
Yiyang Qin +8 more
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When fat goes down, prostate cancer is on the ropes
Molecular & Cellular Oncology, 2019 Reprogrammed lipid metabolism and persistent androgen receptor signaling commonly mark aggressive prostate cancer. We describe that targeting de-novo lipogenesis deprives prostate cancer cells of substrates and fuel, while inhibiting androgen receptor ...
Giorgia Zadra, Massimo Loda
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Cellular Physiology and Biochemistry, 2014 Background/Aims: Fetuin-A (alpha-2-HS-glycoprotein, AHSG), a liver borne plasma protein, contributes to the prevention of soft tissue calcification, modulates inflammation, reduces insulin sensitivity and fosters weight gain following high fat diet or ...
Jakob Voelkl +8 more
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Cinical Significance of Androgen Receptor, CK-5/6, KI-67 and Molecular Subtypes in Breast Cancer
European Journal of Breast Health, 2014 Objective: To detect the relationship between molecular subtypes of breast cancer with expressions of androgen receptor, cytokeratin 5/6 (CK5/6)and Ki-67.Materials and Methods: Expressions of androgen receptor, CK5/6 and Ki67 were determined by ...
Münire Kayahan +5 more
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The androgen/androgen receptor axis in prostate cancer [PDF]
Current Opinion in Oncology, 2012 The review highlights recently discovered mechanisms that sustain castration-resistant prostate cancer (CRPC) growth and describes advances in CRPC therapeutics.Recent reports have shed new light on the molecular processes underlying CRPC survival during androgen deprivation therapy (ADT).
Peter S. Nelson, Eric G. Bluemn
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Effect of dihydrotestosterone on the expression of mucin 1 and the activity of Wnt signaling in mouse corneal epithelial cells [PDF]
International Journal of Ophthalmology, 2016 AIM: To explore the effects of the androgen dihydrotestosterone on the expression of mucin 1 (MUC1) and the activity of Wnt signaling in mouse corneal epithelial cells.
Li Qin +4 more
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