Results 41 to 50 of about 110,485 (214)

Pre-receptor regulation of the androgen receptor [PDF]

open access: yesMolecular and Cellular Endocrinology, 2008
The human androgen receptor (AR) is a ligand-activated nuclear transcription factor and mediates the induction of genes involved in the development of the male phenotype and male secondary sex characteristics, as well as the normal and abnormal growth of the prostate.
Trevor M. Penning   +3 more
openaire   +3 more sources

Current Status and Future Perspectives of Androgen Receptor Inhibition Therapy for Prostate Cancer: A Comprehensive Review

open access: yesBiomolecules, 2021
The androgen receptor (AR) is one of the main components in the development and progression of prostate cancer (PCa), and treatment strategies are mostly directed toward manipulation of the AR pathway.
Tae Jin Kim, Young Hwa Lee, Kyo Chul Koo
doaj   +1 more source

Evaluation of Second-Line Treatment for Castration-Resistant Prostate Cancer following the Administration of Upfront Androgen Receptor Signaling Inhibitors

open access: yesProstate Cancer
This study evaluated the effects of docetaxel and androgen receptor signaling inhibitors as second-line treatments in patients with castration-resistant prostate cancer after androgen receptor signaling inhibitors as first-line treatment.
Kazuro Kikkawa   +7 more
doaj   +1 more source

Molecular Modeling Studies of Natural Inhibitors of Androgen Signaling in Prostate Cancer

open access: yesCancer Informatics, 2022
Prostate cancer is the second most common disease in men and the sixth leading cause of death from cancer globally, with 20 million men expected to be affected by 2024 thus considered as chronic illness which requires immediate attention.
Samuel O Olubode   +8 more
doaj   +1 more source

Reduced mesencephalic astrocyte–derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

open access: yesNeural Regeneration Research
Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene, which encodes a ligand-dependent transcription factor.
Yiyang Qin   +8 more
doaj   +1 more source

When fat goes down, prostate cancer is on the ropes

open access: yesMolecular & Cellular Oncology, 2019
Reprogrammed lipid metabolism and persistent androgen receptor signaling commonly mark aggressive prostate cancer. We describe that targeting de-novo lipogenesis deprives prostate cancer cells of substrates and fuel, while inhibiting androgen receptor ...
Giorgia Zadra, Massimo Loda
doaj   +1 more source

Up-Regulation of Hepatic Alpha-2-HS-Glycoprotein Transcription by Testosterone via Androgen Receptor Activation

open access: yesCellular Physiology and Biochemistry, 2014
Background/Aims: Fetuin-A (alpha-2-HS-glycoprotein, AHSG), a liver borne plasma protein, contributes to the prevention of soft tissue calcification, modulates inflammation, reduces insulin sensitivity and fosters weight gain following high fat diet or ...
Jakob Voelkl   +8 more
doaj   +1 more source

Cinical Significance of Androgen Receptor, CK-5/6, KI-67 and Molecular Subtypes in Breast Cancer

open access: yesEuropean Journal of Breast Health, 2014
Objective: To detect the relationship between molecular subtypes of breast cancer with expressions of androgen receptor, cytokeratin 5/6 (CK5/6)and Ki-67.Materials and Methods: Expressions of androgen receptor, CK5/6 and Ki67 were determined by ...
Münire Kayahan   +5 more
doaj   +1 more source

The androgen/androgen receptor axis in prostate cancer [PDF]

open access: yesCurrent Opinion in Oncology, 2012
The review highlights recently discovered mechanisms that sustain castration-resistant prostate cancer (CRPC) growth and describes advances in CRPC therapeutics.Recent reports have shed new light on the molecular processes underlying CRPC survival during androgen deprivation therapy (ADT).
Peter S. Nelson, Eric G. Bluemn
openaire   +3 more sources

Effect of dihydrotestosterone on the expression of mucin 1 and the activity of Wnt signaling in mouse corneal epithelial cells [PDF]

open access: yesInternational Journal of Ophthalmology, 2016
AIM: To explore the effects of the androgen dihydrotestosterone on the expression of mucin 1 (MUC1) and the activity of Wnt signaling in mouse corneal epithelial cells.
Li Qin   +4 more
doaj   +1 more source

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