Results 61 to 70 of about 204,414 (356)

Androgen receptors as a prognostic and predictive factor in breast cancer.

open access: yesFolia Histochemica et Cytobiologica, 2008
Many theoretical and experimental models indicate that androgen receptors can play an important role as prognostic factors in breast cancer. The aim of this study was to evaluate the correlations between the presence of androgen receptors on cancer cells
Jerzy Rudnicki   +5 more
doaj   +1 more source

SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells

open access: yesScientific Reports, 2021
Prostate cancer is the second most frequent cancer diagnosed in men worldwide. Localized disease can be successfully treated, but advanced cases are more problematic. After initial effectiveness of androgen deprivation therapy, resistance quickly occurs.
Diana Trnski   +10 more
doaj   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, Volume 19, Issue 7, Page 2056-2073, July 2025.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

Statin-Induced Rhabdomyolysis Due to Pharmacokinetic Changes From Biliary Obstruction in a Patient With Metastatic Prostate Cancer

open access: yesJournal of Investigative Medicine High Impact Case Reports, 2020
Statins work synergistically with androgen receptor blockers and androgen biosynthesis inhibitors, improving survival in patients with metastatic castration resistant prostate cancers (mCRPCs).
Sai Prasad Desikan MD   +3 more
doaj   +1 more source

Androgens and androgen receptor signaling in prostate tumorigenesis [PDF]

open access: yesJournal of Molecular Endocrinology, 2014
Androgens and androgen receptor (AR) signaling are necessary for prostate development and homeostasis. AR signaling also drives the growth of nearly all prostate cancer cells. The role of androgens and AR signaling has been well characterized in metastatic prostate cancer, where it has been shown that prostate cancer cells are exquisitely adept at ...
Jeremy O. Jones, Eric C. Bolton, Ye Zhou
openaire   +2 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

Androgen insensitivity syndrome (AIS) [PDF]

open access: yes, 2012
SummaryAndrogen insensitivity syndrome in its complete form is a disorder of hormone resistance characterised by a female phenotype in an individual with an XY karyotype and testes producing age-appropriate normal concentrations of androgens ...
Bunch, Trevor I.   +5 more
core   +1 more source

Androgen Receptor

open access: yes, 2016
The androgen receptor (AR) is a nuclear receptor that functions as a transcription factor and regulates the development and growth of the prostate. The AR, when bound by a ligand, complexes with DNA at androgen response elements in the promoter region of target genes.
Päivi Sutinen   +2 more
openaire   +3 more sources

Androgen Receptor

open access: yes, 2018
The majority of physiological actions of testosterone and dihydrotestosterone are mediated by the androgen receptor, a member of the nuclear receptor superfamily, encoded as a single gene on the X-chromosome. Androgen receptor has four functional domains, N-terminal, DNA binding, hinge and ligand binding.
McEwan, IJ, Smith, LB
openaire   +2 more sources

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

Home - About - Disclaimer - Privacy