Results 61 to 70 of about 194,953 (255)

Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy. [PDF]

, 2017
Androgen receptor (AR) signaling remains the major oncogenic pathway in prostate cancer (PCa). Androgen-deprivation therapy (ADT) is the principle treatment for locally advanced and metastatic disease.
Cucchiara, Vito, Evans, Christopher P, Gao, Allen C, Mirone, Vincenzo, Rosenfeld, Michael G, Yang, Joy C   +5 more
core   +2 more sources

When fat goes down, prostate cancer is on the ropes

Molecular & Cellular Oncology, 2019
Reprogrammed lipid metabolism and persistent androgen receptor signaling commonly mark aggressive prostate cancer. We describe that targeting de-novo lipogenesis deprives prostate cancer cells of substrates and fuel, while inhibiting androgen receptor ...
Giorgia Zadra, Massimo Loda
doaj   +1 more source

Role of imaging in the diagnosis and management of complete androgen insensitivity syndrome in adults [PDF]

, 2013
Complete androgen insensitivity syndrome is an X-linked recessive androgen receptor disorder characterized by a female phenotype with an XY karyotype.
De Visschere, Pieter, Nezzo, Marco, T'Sjoen, Guy, Villeirs, Geert, Weyers, Steven   +4 more
core   +4 more sources

Evaluation of Second-Line Treatment for Castration-Resistant Prostate Cancer following the Administration of Upfront Androgen Receptor Signaling Inhibitors

Prostate Cancer
This study evaluated the effects of docetaxel and androgen receptor signaling inhibitors as second-line treatments in patients with castration-resistant prostate cancer after androgen receptor signaling inhibitors as first-line treatment.
Kazuro Kikkawa, Masahiro Tamaki, Kouhei Maruno, Tatsuya Hazama, Toshifumi Takahashi, Yuya Yamada, Masakazu Nakashima, Noriyuki Ito   +7 more
doaj   +1 more source

Reduced mesencephalic astrocyte–derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

Neural Regeneration Research
Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene, which encodes a ligand-dependent transcription factor.
Yiyang Qin, Wenzhen Zhu, Tingting Guo, Yiran Zhang, Tingting Xing, Peng Yin, Shihua Li, Xiao-Jiang Li, Su Yang   +8 more
doaj   +1 more source

Molecular Modeling Studies of Natural Inhibitors of Androgen Signaling in Prostate Cancer

Cancer Informatics, 2022
Prostate cancer is the second most common disease in men and the sixth leading cause of death from cancer globally, with 20 million men expected to be affected by 2024 thus considered as chronic illness which requires immediate attention.
Samuel O Olubode, Mutolib O Bankole, Precious A Akinnusi, Olayinka S Adanlawo, Kehinde I Ojubola, Daniel O Nwankwo, Onome E Edjebah, Ayomide O Adebesin, Abigail O Ayodele   +8 more
doaj   +1 more source

Transcriptional regulation of prostate kallikrein-like genes by androgen. [PDF]

, 1992
Using gene-specific synthetic oligonucleotides the expression and regulation of kallikrein-like genes in the human prostatic cancer cell line LNCaP were studied.
Fittler, Friedrich, Schulz, Peter, Wolf, Dieter A.   +2 more
core   +1 more source

Cinical Significance of Androgen Receptor, CK-5/6, KI-67 and Molecular Subtypes in Breast Cancer

European Journal of Breast Health, 2014
Objective: To detect the relationship between molecular subtypes of breast cancer with expressions of androgen receptor, cytokeratin 5/6 (CK5/6)and Ki-67.Materials and Methods: Expressions of androgen receptor, CK5/6 and Ki67 were determined by ...
Münire Kayahan, Ufuk Oguz İdiz, Zuhal Gucin, Fazilet Erozgen, Naim Memmi, Mahmut Müslümanoğlu   +5 more
doaj   +1 more source

Up-Regulation of Hepatic Alpha-2-HS-Glycoprotein Transcription by Testosterone via Androgen Receptor Activation

Cellular Physiology and Biochemistry, 2014
Background/Aims: Fetuin-A (alpha-2-HS-glycoprotein, AHSG), a liver borne plasma protein, contributes to the prevention of soft tissue calcification, modulates inflammation, reduces insulin sensitivity and fosters weight gain following high fat diet or ...
Jakob Voelkl, Tatsiana Pakladok, Yun Lin, Robert Viereck, Aleksandra Lebedeva, Damaris Kukuk, Bernd J. Pichler, Ioana Alesutan, Florian Lang   +8 more
doaj   +1 more source

Effects of antiandrogens on transformation and transcription activation of wild-type and mutated (LNCaP) androgen receptors [PDF]

, 1993
LNCaP cells contain androgen receptors with a mutation in the steroid binding domain (Thr 868 changed to Ala) resulting in a changed hormone specificity. Both the wild-type and mutated androgen receptors were transfected into COS cells.
Berrevoets, C.A. (Cor), Mulder, E. (Eppo), Veldscholte, J. (Jos)   +2 more
core   +1 more source