Results 121 to 130 of about 18,995 (290)

Abstract 5782: Androgen receptor antagonists: Lead optimization and preclinical pharmacology

, 2010
The development and progression of prostate cancer is known to be dependent on androgens and their signaling mediated by the androgen receptor (AR). The primary therapeutic intervention involves using agents that lower serum testosterone (e.g., LHRH ...
Yuwei Tang, Celeste Twamley, Liang Schweizer, Wen-Ching Han, Punit Marathe, Maria Jure-Kunkel, Litai Zhang, William Foster, Gregg Masters, Georgia Cornelius, Yufen Zhao, Paul Elzinga, Weifang Shan, Derek Norris, Donald Apanovitch, Andrew Nation, Cheryl Rizzo, Joel Austin, Mary Obermeier, Marco Gottardis, Mary Ellen Cvijic, Lisa Sharma, Arvind Mathur, Janet Dell-John, Dauh-Rurng Wu, Benjamin Johnson, Aaron Balog, Gregory Vite, Ricardo Attar, Ashvin Gavai, Gennaro Dito, Melissa Yarde   +31 more
core   +1 more source

Cheminformatic Analysis and Machine Learning Modeling to Investigate Androgen Receptor Antagonists to Combat Prostate Cancer. [PDF]

ACS Omega, 2023
Yu T, Nantasenamat C, Kachenton S, Anuwongcharoen N, Piacham T.   +4 more
europepmc   +1 more source

Essential embryology for the Canadian pathologists’ assistant

Anatomical Sciences Education, EarlyView.
Abstract Pathologists' assistants (PAs) are pivotal in healthcare, conducting autopsies and examining tissues under a pathologist's guidance. Embryology knowledge is crucial for PAs to accurately assess anomalies and identify pathologies. Yet, it is often overlooked in academic PA training programs.
Samantha H. Nacci, William Tsui, Fang‐I Lu, Avrum I. Gotlieb, Danielle C. Bentley   +4 more
wiley   +1 more source

Тіе Modern treatment of androgenetic alopecia

Vestnik Dermatologii i Venerologii, 2017
Androgenetic alopecia (AGA) is the most common reason for hair loss. Its frequency in Caucasian population is up to 80% in men and 42% in women. Current gold standard for AGA treatment includes minoxidil and/or finasteride.
V. K. Karnaukhov, A. A. Lukyanova, M. I. Lukashina, E. S. Vorobeva, I. M. Afanasov   +4 more
doaj   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

Binding of Clucocorticoid Antagonists To Androgen and Glucocorticoid Hormone Receptors in Rat Skeletal-muscle

, 1986
The binding of ten steroids possessing antiglucocorticoid activity has been studied in rat skeletal muscle cytosol. The affinity of these steroids for both the androgen and the glucocorticoid receptors was determined by competition with radioactive R1881
Rousseau, Guy, Danhaive, P A, Rousseau, GG., Danhaive, PA.   +3 more
core   +1 more source

Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer

, 2020
The androgen receptor (AR) plays a leading role in the control of prostate cancer (PCa) growth. Interestingly, structurally different AR antagonists with distinct mechanisms of antagonism induce cell senescence, a mechanism that inhibits cell cycle ...
Kimia Mirzakhani, Thanakorn Pungsrinont, Miriam Kokal, Aria Baniahmad   +3 more
core   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, EarlyView.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source

Time trends of drug-specific actionable adverse events among patients on androgen receptor antagonists: Implications for remote monitoring. [PDF]

Can Urol Assoc J, 2022
Fleshner L, Berlin A, Hersey K, Kenk M, Lajkosz K, Nguyen S, Wise J, O'Halloran S.   +7 more
europepmc   +1 more source