Results 141 to 150 of about 18,995 (290)

Androgen deprivation induces double-null prostate cancer via aberrant nuclear export and ribosomal biogenesis through HGF and Wnt activation

Nature Communications
Androgen deprivation therapy (ADT) targeting androgen/androgen receptor (AR)- signaling pathways is the main therapy for advanced prostate cancer (PCa). However, ADT eventually fails in most patients who consequently develop castration-resistant prostate
Won Kyung Kim, Alyssa J. Buckley, Dong-Hoon Lee, Alex Hiroto, Christian H. Nenninger, Adam W. Olson, Jinhui Wang, Zhuo Li, Rajeev Vikram, Yao Mawulikplimi Adzavon, Tak-yu Yau, Yigang Bao, Michael Kahn, Joseph Geradts, Guang-Qian Xiao, Zijie Sun   +15 more
doaj   +1 more source

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

Interdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang, Fan Zou, Mingdong Wang, Chenyue Wu, Yingwei Xie, Yongjun Quan, Wei Yan, Yupeng Zheng, Lianhua Li, Yuexin Liu, Jian Yu, Hao Ping   +11 more
wiley   +1 more source

The promise of novel androgen receptor antagonists [PDF]

Cell Cycle, 2010
openaire   +2 more sources

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

The TRPM2–PARP‐1 Axis Involvement in Bisphenol A and Nonylphenol‐Induced Ferroptosis in Trigeminal Ganglion Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental contaminants like bisphenol A (BPA) and nonylphenol (NP) are recognized neurotoxicants; however, the molecular mechanisms underlying their impact on sensory ganglia, specifically the trigeminal ganglion (TG), remain critically underexplored.
Betül Yazğan, Musa Tatar, Yener Yazğan, Kıymet Kübra Tüfekci   +3 more
wiley   +1 more source

Survival of men with metastatic hormone-sensitive prostate cancer and adrenal-permissive HSD3B1 inheritance

The Journal of Clinical Investigation
BACKGROUND Metastatic hormone-sensitive prostate cancer (mHSPC) is androgen dependent, and its treatment includes androgen deprivation therapy (ADT) with gonadal testosterone suppression. Since 2014, overall survival (OS) has been prolonged with addition
Nima Sharifi, Robert Diaz, Hui-Ming Lin, Evan Roberts, Lisa G. Horvath, Andrew Martin, Martin R. Stockler, Sonia Yip, Vinod V. Subhash, Neil Portman, Ian D. Davis, Christopher J. Sweeney   +11 more
doaj   +1 more source

Exploration of the Activity, Delivery and Activation of Androgen Receptor Potential Indane Scaffold Antagonists for Prostate Cancer Treatment

Androgen receptor (AR)-targeted therapy remains the gold standard strategy for the treatment of advanced prostate cancer. Several compounds of Indane derivatives have been reported to exhibit significant AR antagonist capabilities, starting at a ...
Kinsella, Gemma K, Zhang, Shengxin, Curtin, James F., Zhang, Tao   +3 more
core   +1 more source

Age‐Associated Variations in Complete Blood Cell Count Parameters and Derived Indices Among Community‐Dwelling Chinese Older Adults

Journal of Clinical Laboratory Analysis, EarlyView.
This cross‐sectional study analyzed data from 9331 participants aged 24–97 to characterize age‐ and sex‐related physiological trajectories of complete blood cell count (CBC) parameters and derived inflammatory indices. Key findings encompassed age‐related declines in red blood cell and platelet counts, elevations in RDW‐CV indices and monocyte ...
Xiangyi Ma, Na Liu, Xiang Wu, Qiudan Chen, Xiaotong Chen, Qingyu Zhou, Shuying Chen, Yong Lin, Xuefeng Wang   +8 more
wiley   +1 more source

Risk Factors Influencing Efficacy and Prognosis Evaluation of Neoadjuvant Systemic Therapy in Triple‐Positive Breast Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT To identify the determinants of the response to neoadjuvant systemic therapy (NST) in triple‐positive breast cancer (TPBC), we retrospectively enrolled 520 patients with human epidermal growth factor receptor 2 (HER2)‐positive breast cancer who were treated at The First Affiliated Hospital of Chongqing Medical University between January 2015 ...
Lin‐Rui Miao, Hao Liu, Hai‐Ying Yu, Jian Chen, Ming‐Yu Yang, Ya‐Lan Zhang, Gang Tu, Ling‐Feng Tang   +7 more
wiley   +1 more source