Results 221 to 230 of about 141,437 (356)

Additional file 6 of ERG inhibition selectively sensitizes ERG-positive prostate cancer to radiation through DNA repair vulnerabilities and enhances response to androgen receptor inhibitors

Ayham Moustafa, Mohamed E. Elsesy, Bente Siebels, Jan Hahn, Su Jung Oh‐Hohenhorst, Carlotta Schudy, Thorsten Rieckmann, Susanne Burdak‐Rothkamm, Derya Tilki A, Tobias Maurer, Cordula Petersen, Kai Rothkamm, Gunhild v. Amsberg, Carsten Bokemeyer, Hartmut Schlüter, Sabrina Köcher, Wael Yassin Mansour   +16 more
openalex   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

Dihydrotestosterone Promotes Hetian Sheep Dermal Papilla Cell Proliferation by Inhibiting the TGF-β/Smad Signalling Pathway. [PDF]

Vet Med Sci
Wang Q, Liu X, Feng Z, Zhang J, Li C, Shi R, Li S.   +6 more
europepmc   +1 more source

Additional file 1 of ERG inhibition selectively sensitizes ERG-positive prostate cancer to radiation through DNA repair vulnerabilities and enhances response to androgen receptor inhibitors

Ayham Moustafa, Mohamed E. Elsesy, Bente Siebels, Jan Hahn, Su Jung Oh‐Hohenhorst, Carlotta Schudy, Thorsten Rieckmann, Susanne Burdak‐Rothkamm, Derya Tilki A, Tobias Maurer, Cordula Petersen, Kai Rothkamm, Gunhild v. Amsberg, Carsten Bokemeyer, Hartmut Schlüter, Sabrina Köcher, Wael Yassin Mansour   +16 more
openalex   +1 more source

Androgen Receptor (AR) Expression is Associated with an Immune-Cold Phenotype and Reduced Response to Immune Checkpoint Inhibitors in ER-Positive/HER2-Negative Breast Cancer [PDF]

Jun Arima, Kohei Chida, Rongrong Wu, Takafumi Shima, Toru Kuramoto, Hiroki Hamamoto, Kohei Taniguchi, Zunairah Shah, Kenichi Hakamada, Takashi Ishikawa, Seita Hagihara, Kosei Kimura, Mitsuhiko Iwamoto, Sang‐Woong Lee, Kazuaki Takabe   +14 more
openalex   +1 more source

Diabetes‐Induced Dysregulation of Purinergic Signaling in the Bladder Mucosa: Accelerated ATP Hydrolysis and Impaired Adenosine Uptake Promote Underactive Bladder Phenotype

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objective To explore molecular mechanisms underlying excessive extracellular adenosine (ADO) accumulation in the bladder lamina propria (LP) of mice with type 2 diabetes (T2D) induced by a high‐fat, high‐sucrose diet (HFHSD), conceivably leading to bladder underactivity.
Mahsa Borhani Peikani, Brian A. Perrino, Violeta N. Mutafova‐Yambolieva   +2 more
wiley   +1 more source

The Expression of Placental 17β-Hydroxysteroid Dehydrogenase Genes Is Associated with the Elevation of Active Androgens and Estrogens in Pregnant Women, but Does Not Affect 11-Oxygenated C19 Steroids. [PDF]

Int J Mol Sci
Yokohama Y, Watanabe Y, Nakajima KI, Umezawa A, Takahashi S, Mori Y, Kato Y, Kawabe JI, Yazawa T.   +8 more
europepmc   +1 more source

Single-Cell Sequencing Reveals Androgen Deficiency Arrests Meibocyte Differentiation and Impairs EMC-Mediated Lipid Metabolism

Shenchuan Qian, Zihao Liu, Mike Pan, 朱美玲, Juan Li, Yuyang Fu, Qian Li, Zhiwei Zha, Ying Feng, Wei Chen   +9 more
openalex   +1 more source

A transition zone enriched WIF1+ basal cell subtype is associated with benign prostatic hyperplasia

The Journal of Pathology, EarlyView.
Abstract The cellular composition and disease susceptibilities of the distinct zones of the human prostate remain incompletely understood. Benign prostatic hyperplasia (BPH) is a common condition that causes widespread morbidity and is nearly exclusively localized to the transition zone (TZ).
Rulin Wang, Qizhi Zheng, Mindy K Graham, Ajay Vaghasia, Jianyong Liu, Jordan Gregg, Tracy Jones, Anuj Gupta, Nicole Castagna, Yan Zhang, Kornel Schuebel, Jennifer Meyers, Alyza Skaist, Dixie Hoyle, Jasmine Kung, Jessica Hicks, Alok Mishra, Yuhan Yang, William G Nelson, Angelo M De Marzo, Srinivasan Yegnasubramanian   +20 more
wiley   +1 more source

CAFs‐mediated histone lactylation reprograms cholesterol metabolism in colorectal cancer to drive CD8+ T cell immunosuppression

The Journal of Pathology, EarlyView.
Abstract The progression of colorectal cancer (CRC) is critically regulated by cancer‐associated fibroblasts (CAFs) within the tumor microenvironment (TME), yet the specific molecular mechanisms by which CAFs influence CRC remain unclear. This study reveals the mechanism by which CAFs promote CRC malignant progression and immune suppression through ...
Huachi Li, Jun Hu, Lei Huang, Zihao Wang, Haoran Tao, Feng Cao, Min Xie   +6 more
wiley   +1 more source