Results 31 to 40 of about 59,669 (148)

A Small Peptide Targeting the Ligand-Induced Androgen Receptor/Filamin a Interaction Inhibits the Invasive Phenotype of Prostate Cancer Cells

Cells, 2021
Prostate cancer (PC) is one of the most widespread malignancies among males worldwide. The androgen receptor (AR) plays a major role in prostate cancer development and progression and is the main target of PC therapy.
Marzia Di Donato, Pia Giovannelli, Maria Vittoria Barone, Ferdinando Auricchio, Gabriella Castoria, Antimo Migliaccio   +5 more
doaj   +1 more source

Circulating adrenal and gonadal steroid hormones heterogeneity in active young males and the contribution of 11-oxy androgens

Scientific Reports
The classical androgens, testosterone and dihydrotestosterone, together with dehydroepiandrosterone, the precusrsor to all androgens, are generally included in diagnostic steroid evaluations of androgen excess and deficiency disorders and monitored in ...
Amanda C. Swart, Desmaré van Rooyen, Therina du Toit, Bianca Heyns, John Molphy, Mathew Wilson, Roisin Leahy, Stephen L. Atkin   +7 more
doaj   +1 more source

Androgens and cardiac diseases

Monaldi Archives for Chest Disease, 2013
Although androgens have been considered deleterious for the cardiovascular system, recent data have demonstrated favourable testosterone effects on cardiac and vascular remodeling and clinical outcome.
Vittorio Bianchi, Alessandro Mezzani
doaj   +1 more source

Gender Differences in the Pathogenesis and Risk Factors of Hepatocellular Carcinoma

Biology, 2023
Several chronic liver diseases are characterized by a clear gender disparity. Among them, hepatocellular carcinoma (HCC) shows significantly higher incidence rates in men than in women. The different epidemiological distribution of risk factors for liver
Riccardo Nevola, Giovanni Tortorella, Valerio Rosato, Luca Rinaldi, Simona Imbriani, Pasquale Perillo, Davide Mastrocinque, Marco La Montagna, Antonio Russo, Giovanni Di Lorenzo, Maria Alfano, Maria Rocco, Carmen Ricozzi, Klodian Gjeloshi, Ferdinando Carlo Sasso, Raffaele Marfella, Aldo Marrone, Loreta Anesti Kondili, Nicolino Esposito, Ernesto Claar, Domenico Cozzolino   +20 more
doaj   +1 more source

Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients

Viruses, 2022
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), is estimated to have caused over 6.5 million deaths worldwide. The emergence of fast-evolving SARS-CoV-2 variants of concern alongside increased transmissibility and/or
Efstathios S. Giotis, Emine Cil, Greg N. Brooke   +2 more
doaj   +1 more source

Inhibition of Apoptosis in Prostate Cancer Cells by Androgens Is Mediated through Downregulation of c-Jun N-terminal Kinase Activation

Neoplasia: An International Journal for Oncology Research, 2008
Androgen deprivation induces the regression of prostate tumors mainly due to an increase in the apoptosis rate; however, the molecular mechanisms underlying the antiapoptotic actions of androgens are not completely understood.
Petra Isabel Lorenzo, Fahri Saatcioglu
doaj   +1 more source

POSTMENOPAUSAL HIRSUTISM: A CASE REPORT

Khyber Medical University Journal, 2021
INTRODUCTION:  Hirsutism is a common condition affecting around 5-10% of female in the childbearing age. During menopausal evolution phase some terminal hair growth can occur in few females as part of normal aging process.
Tahir Ghaffar, Suleman Elahi Malik, Sima Zeb, Zafran Ullah, Shaista Kanwal, Azizul Hasan Aamir   +5 more
doaj   +1 more source

The multiple actions of testosterone in men: nature knows best

Asian Journal of Andrology, 2014
In male hormone replacement therapy Finkelstein et al. show that testosterone rather than synthetic "pure" androgens should be prescribed. Testosterone is converted to the superactive androgen dihydrotestosterone and to estradiol, and thus has actions ...
John W Funder
doaj   +1 more source

Effects of Sex Steroids on Fish Leukocytes

Biology, 2018
In vertebrates, in addition to their classically reproductive functions, steroids regulate the immune system. This action is possible mainly due to the presence of steroid receptors in the different immune cell types.
Elena Chaves-Pozo, Alfonsa García-Ayala, Isabel Cabas   +2 more
doaj   +1 more source

Simultaneous profiling of classic and 11-oxygenated androgens via a novel derivatization method coupled with HPLC-MS/MS: A game-changer for endocrine disorders

Talanta Open
The accumulation of classic or 11-oxygenated androgens is a hallmark of polycystic ovary syndrome (PCOS). Traditional electrochemiluminescence immunoassays (ECLIA) are limited in their ability to measure a broad spectrum of androgens and may suffer from ...
Xianhua Zhang, Huiyu Xu, Yue Sun, Xin Xiong, Lingling Liu, Li Yang, Libo Zhao, Xiaona Li, Rong Li, Rongsheng Zhao   +9 more
doaj   +1 more source