Results 11 to 20 of about 81,239 (301)
Endocrine Reviews, 2004 Loss of estrogens or androgens increases the rate of bone remodeling by removing restraining effects on osteoblastogenesis and osteoclastogenesis, and also causes a focal imbalance between resorption and formation by prolonging the lifespan of osteoclasts and shortening the lifespan of osteoblasts.
Liesbeth Vandenput +2 more
exaly +4 more sources
Androgens and Androgen Receptor Actions on Bone Health and Disease: From Androgen Deficiency to Androgen Therapy [PDF]
Cells, 2019 Androgens are not only essential for bone development but for the maintenance of bone mass. Therefore, conditions with androgen deficiency, such as male hypogonadism, androgen-insensitive syndromes, and prostate cancer with androgen deprivation therapy ...
Jia-Feng Chen +4 more
doaj +3 more sources
The role of 11-oxygenated androgens in prostate cancer [PDF]
Endocrine Oncology, 2023 11-oxygenated androgens are a class of steroids capable of activating the androgen receptor (AR) at physiologically relevant concentrations. In view of the AR as a key driver of prostate cancer (PC), these steroids are potential drivers of disease and ...
Gido Snaterse +2 more
doaj +2 more sources
Androgens and the breast [PDF]
Breast Cancer Research, 2009 Androgens have important physiological effects in women while at the same time they may be implicated in breast cancer pathologies. However, data on the effects of androgens on mammary epithelial proliferation and/or breast cancer incidence are not in full agreement.
Dimitrakakis, Constantine +1 more
core +5 more sources
Androgens and prostate disease
Asian Journal of Andrology, 2014 A growing body of literature has established the anabolic benefi ts of testosterone (T) therapy in hypogonadal men. However, there remains a paucity of data regarding the risks of exogenous androgen use in older men and the potential for adverse effects ...
Lori A Cooper, Stephanie T Page
doaj +2 more sources
Androgens and the androgen receptor (AR)
, 2013 Introduction Androgens are sex steroid hormones that are produced in both males and females, albeit in different amounts. Androgens are essential for development and maintenance of the male phenotype (1), and are also important in females, where they can either act directly via the androgen receptor (AR) or indirectly as metabolic precursors for ...
Moore, N. +4 more
openaire +3 more sources
Frontiers in Endocrinology, 2023 An increasing number of studies have reported that androgens and androgen receptors (AR) play important roles in the regulation of glucose and lipid metabolism.
Lijun Yin, Shuo Qi, Zhiqiang Zhu
doaj +1 more source
Frontiers in Immunology, 2020 Androgens, the predominant male sex hormones, drive the development and maintenance of male characteristics by binding to androgen receptor (AR). As androgens are systemically distributed throughout the whole organism, they affect many tissues and cell ...
Mireya Becerra-Diaz +2 more
doaj +1 more source
Androgens and low density lipoprotein-cholesterol interplay in modulating prostate cancer cell fate and metabolism [PDF]
, 2022 Background: Androgens, the known drivers of prostate cancer (PCa), have been indicated as important metabolic regulators with a relevant role in stimulating lipid metabolism.
Vaz, Cátia V. +6 more
core +1 more source
Investigating the role of androgens in myometrial biology during pregnancy [PDF]
, 2015 Understanding the physiology of pregnancy enables effective management of pregnancy complications that could otherwise be life threatening for both mother and fetus.
Makieva, Sofia
core +3 more sources