Results 71 to 80 of about 238,876 (343)
Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome
Frontiers in Endocrinology, 2020 Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the ...
Didier Dewailly +9 more
doaj +1 more source
Advanced Science, EarlyView.This study demonstrates that patients with PCOS exhibit altered gut microbial profiles, and FMT from PCOS patients induces PCOS‐like symptoms in mice. Specifically, gut dysbiosis reduces 3‐HAA levels in the context of PCOS. Administration of 3‐HAA to mice alleviates PCOS by promoting de novo NAD+ synthesis.
Ke Chen +6 more
wiley +1 more source
Talanta OpenThe accumulation of classic or 11-oxygenated androgens is a hallmark of polycystic ovary syndrome (PCOS). Traditional electrochemiluminescence immunoassays (ECLIA) are limited in their ability to measure a broad spectrum of androgens and may suffer from ...
Xianhua Zhang +9 more
doaj +1 more source
The use of digit ratios as markers for perinatal androgen action
Reproductive Biology and Endocrinology, 2006 Since the ratio of the second-to-fourth finger length was first proposed as a marker for prenatal androgen action in 1998, over 100 studies have been published that have either further tested the association between the digit ratio and prenatal androgens,
McIntyre Matthew H
doaj +1 more source
Neurology of Androgens and Androgenic Supplements
Current Neurology and Neuroscience ReportsAbstract Purpose of Review This article explores the intricate relationship between androgens, androgen receptors, and the central nervous system. We examine the role of physiologically derived androgens and androgenic supplements in neurodevelopment and neuroplasticity and delve into the involvement of androgen ...
Dengri, Chetna +3 more
openaire +1 more source
Advanced Science, EarlyView.The study shows that liver is a previously unrecognized extraovarian organ that plays a key role about androgen homeostasis in the development of DHEA‐induced PCOS. DHEA is the most common precursor of active androgen, such as DHT, and KLF9 is required for the conversion of DHEA to DHT and hepatic KLF9 might be a potential therapeutic target for PCOS ...
Jianli Song +11 more
wiley +1 more source
The Roles of Androgen Receptors and Androgen-Binding Proteins in Nongenomic Androgen Actions [PDF]
Molecular Endocrinology, 2002 AbstractThe biological activity of testosterone and dihydrotestosterone is thought to occur predominantly through binding to the androgen receptor (AR), a member of the nuclear receptor superfamily that functions as a ligand-activated transcription factor.
Chawnshang Chang, Cynthia A. Heinlein
openaire +3 more sources
Advanced Science, EarlyView.Expanding enzalutamide (ENZ) use in hormone‐sensitive prostate cancer (HSPC) faces resistance. Single‐cell profiling identifies therapy‐resistant STEAP4+ myofibroblastic cancer‐associated fibroblast (SETAP4+ myoCAF). These myoCAFs drive resistance via TFE3‐mediated autophagy and PCYT1A‐led phosphatidylcholine overproduction, creating a phospholipid ...
Wenhao Wang +14 more
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
The Vietnamese swine as a translational model of invasive ductal carcinoma of the breast
Animal Models and Experimental Medicine, EarlyView.The flow diagram outlines the chemical induction of breast tumors through a single intraperitoneal dose of MNU. Tumor development was assessed using ultrasound and clinical examination. After 14 weeks, mammary tissue was collected and histologically analyzed to evaluate structural similarities between sows and humans, the carcinogenic potential of MNU,
Claudia Elizabeth Vera‐Tizatl +6 more
wiley +1 more source