Results 11 to 20 of about 4,348 (183)

Influence of andrographolide on the pharmacokinetics of warfarin in rats [PDF]

Pharmaceutical Biology, 2018
Context: Andrographolide and warfarin are often used together in clinics in China. However, the herb-drug interaction between andrographolide and warfarin is still unknown.
Xiaoli Zhang, Xiaosu Zhang, Xiaocui Wang, Meijun Zhao   +3 more
doaj   +3 more sources

Study on the mechanism of andrographolide activation

Frontiers in Neuroscience, 2022
Andrographolide is a natural antibiotic that has the ability to dispel heat, detoxify, reduce inflammation, and relieve pain. Recent research has shown that it can exert anti-inflammatory effects via multiple pathways and multiple targets (mediated by NF-κB, JAK/STAT, T cell receptor, and other signaling pathways).
Qihan Cai, Weina Zhang, Yanan Sun, Lu Xu, Mengmeng Wang, Xinliang Wang, Siming Wang, Zhiyu Ni, Zhiyu Ni, Zhiyu Ni   +9 more
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Andrographolide improves PCP-induced schizophrenia-like behaviors through blocking interaction between NRF2 and KEAP1

Journal of Pharmacological Sciences, 2021
Schizophrenia is one of the foremost psychological illness around the world, and recent evidence shows that inflammation and oxidative stress may play a critical role in the etiology of schizophrenia.
Xiying Wang, Jia Liu, Zhiping Dai, Yuxiu Sui   +3 more
doaj   +1 more source

Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB. [PDF]

PLoS ONE, 2013
Nuclear factor-κB (NF-κB) is a central transcriptional factor and a pleiotropic regulator of many genes involved in acute lung injury. Andrographolide is found in the plant of Andrographis paniculata and widely used in Traditional Chinese Medicine ...
Tao Zhu, Dao-xin Wang, Wei Zhang, Xiu-qing Liao, Xian Guan, Hong Bo, Jia-yang Sun, Ni-wen Huang, Jing He, Yun-kun Zhang, Jing Tong, Chang-yi Li   +11 more
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Anti‐diabetic effect of andrographolide from Sambiloto herbs (Andrographis paniculata (Burm.f.) Nees) through the expression of PPARγ and GLUT‐4 in adipocytes

Indonesian Journal of Biotechnology, 2022
Andrographolide has been shown to have a pharmacological effect as an antidiabetic. Nevertheless, the comprehensive mechanism of action has yet to be determined.
Novia Tri Astuti, Putri Rachma Novitasari, Raymond Tjandrawinata, Agung Endro Nugroho, Suwijiyo Pramono   +4 more
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The Effects of Andrographolide on the Enhancement of Chondrogenesis and Osteogenesis in Human Suprapatellar Fat Pad Derived Mesenchymal Stem Cells

Molecules, 2021
Andrographolide is a labdane diterpenoid herb, which is isolated from the leaves of Andrographis paniculata, and widely used for its potential medical properties.
Thitianan Kulsirirat, Sittisak Honsawek, Mariko Takeda-Morishita, Nuttanan Sinchaipanid, Wanvisa Udomsinprasert, Jiraporn Leanpolchareanchai, Korbtham Sathirakul   +6 more
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A critical review of Andrographis paniculata

Medicinal Plant Biology, 2023
Andrographis paniculata, a traditional medicinal plant, is widely used to treat various disorders. According to traditional Chinese medicine (TCM) theory, it is intensely bitter in taste and cold-natured.
Xianghui Chen, Junze Ren, Jindong Yang, Zhanpin Zhu, Ruibing Chen, Lei Zhang   +5 more
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Lipase catalyzed synthesis of antimicrobial andrographolide derivatives

Data in Brief, 2018
In this data article we describe screening of various lipases for the regioselective acylation of Andrographolide. Each lipase was screened with seven acyl donors.
Harshal S. Patil, Dipesh D. Jadhav, Ajay Paul, Fayaj A. Mulani, Shrikant J. Karegaonkar, Hirekodathakallu V. Thulasiram   +5 more
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In silico and in vitro studies on the anti-cancer activity of andrographolide targeting survivin in human breast cancer stem cells.

PLoS ONE, 2020
Breast cancer stem cells (BCSCs) express high levels of the anti-apoptotic protein, survivin. This study aimed to discover a natural active compound with anti-cancer properties that targeted survivin in human breast cancer stem cells.
Septelia Inawati Wanandi, Agus Limanto, Elvira Yunita, Resda Akhra Syahrani, Melva Louisa, Agung Eru Wibowo, Sekar Arumsari   +6 more
doaj   +1 more source

Protective effects of andrographolide on lead-induced kidney injury through inhibiting inflammatory and oxidative responses in common carp

Aquaculture Reports, 2020
Lead, an environmental toxicant in our daily life, has been reported to have adverse effectson human and animals. Previous studies showed lead could accumulate in kidney tissues of carp and cause injury to the kidney tissues.
Yue Zhang, Peijun Zhang, Peng Yu, Xinchi Shang, Yunhe Fu, Yuting Lu, Yuehong Li   +6 more
doaj   +1 more source