Exposure to Androstenes Influences Processing of Emotional Words [PDF]
Frontiers in Ecology and Evolution, 2018 There is evidence that human-produced androstenes affect attitudinal, emotional, and physiological states in a context-dependent manner, suggesting that they could be involved in modulating social interactions.
Patrizia d'Ettorre +6 more
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Neurosteroids as Selective Inhibitors of Glycine Receptor Activity: Structure-Activity Relationship Study on Endogenous Androstanes and Androstenes [PDF]
Frontiers in Molecular Neuroscience, 2020 The ability of androstane and androstene neurosteroids with modifications at C-17, C-5, and C-3 (compounds 1-9) to influence the functional activity of inhibitory glycine and γ-aminobutyric acid (GABA) receptors was estimated.
Julia V. Bukanova +2 more
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Dehydroepiandrosterone and Its Metabolite 5-Androstenediol: New Therapeutic Targets and Possibilities for Clinical Application [PDF]
PharmaceuticalsDehydroepiandrosterone and its sulfate are the most abundant steroids in humans. The metabolism of dehydroepiandrosterone can differ significantly depending on the organ or tissue and the subtype of steroid receptors expressed in it.
Tatiana A. Fedotcheva +3 more
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Androstene-3,5-dienes as ER-β selective SERMs
Bioorganic & Medicinal Chemistry Letters, 2007 A series of androstene-3,5-diene derivatives were prepared. Despite lacking the C-3 hydroxyl previously believed necessary for ER activity, some of the analogs retained surprising affinity for ER-beta. For example, diene 4 retained excellent selectivity and potency as an ER-beta agonist and was more selective for ER-beta over the androgen receptor (AR).
Timothy A. Blizzard +14 more
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METABOLISM OF Δ4-ANDROSTENE-3β, 17β-DIOL AND Δ4-ANDROSTENE-3α, 17β-DIOL IN VITRO
Journal of Biological Chemistry, 1957 Frank Ungar +2 more
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Cells, 2022 We discovered odorous 16-androstenes (Androstenone and Androstenol) in endangered mouse deer during a captive breeding program. This study examined the molecular characteristics, their synthesis pathway, and the possible functional role of these ...
Vinod Kumar +8 more
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Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids
Chemistry Proceedings, 2023 Heterocyclic derivatives of hormones have attracted great interest as a privileged scaffold for drug discovery due to their outstanding biological activity.
Yulia Volkova +2 more
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Synthese van nieuwe sterolen en provitamines D met gewijzigde zijketen [PDF]
, 1951 All sterols which obtain antirachitic activity by ultraviolet irradiation show a conjugated system of double bonds (5,7) in ring B and a hydroxyl group at C3 in the cyclopentanoperhydrophenanthrene skeleton. ...
de Vries, Harmen
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Hypothalamic response to the chemo-signal androstadienone in gender dysphoric children and adolescents. [PDF]
, 2014 peer reviewedThe odorous steroid androstadienone, a putative male chemo-signal, was previously reported to evoke sex differences in hypothalamic activation in adult heterosexual men and women.
Burke, Sarah M. +4 more
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Over-the-Counter Anabolic Steroids 4-Androsten-3,17-dione; 4-Androsten-3 ,17 -diol; and 19-nor-4-Androsten-3,17-dione: Excretion Studies in Men [PDF]
Journal of Analytical Toxicology, 1999 Since the appearance of 4-androsten-3,17-dione (I) as a nutritional supplement in early 1997, we have frequently observed a characteristic deterioration of endogenous steroid profiles in athletes' urine in routine anabolic steroid testing in which concentrations of major endogenous urinary steroids and testosterone exceed normal.
V P, Uralets, P A, Gillette
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