Results 11 to 20 of about 1,570 (204)

Gonadal suppression alters axillary steroid secretions in men, but does that affect olfactory social signaling? [PDF]

, 2021
Background and objective: Luteinizing hormone-releasing hormone agonists (LHRHa) suppress gonadal hormone production and are commonly used to treat prostate cancer (PC) in men and conditions ranging from uterine fibroids to estrogen-sensitive cancers in ...
Abel, Paul D, Adomat, Hans H, Allen, Caroline, Bell, Robert H, Fialova, Jitka Trebicka, Roberts, S Craig, Shah, Syed Imran Ali, Tomlinson Guns, Emma S, Trebicky, Vit, Wassersug, Richard J, Wilson, Hannah C P   +10 more
core   +2 more sources

Determination of 17α-hydroxylase-C_17,20-lyase (P450_17α) enzyme activities and their inhibition by selected steroidal picolyl and picolinylidene compounds [PDF]

, 2015
17α-hydroxylase-C17,20-lyase (P45017α) is a key regulator enzyme of the steroid hormone biosynthesis in both the adrenals and the testes. Inhibition of this enzyme can block androgen synthesis in an early step, and may thereby be useful in the treatment ...
Ajduković, Jovana, Djurendić, Evgenija, Gardi, János, Ignáth, Imre, Jovanović-Šanta, Suzana, Klisurić, Olivera, Mahmoud, Gábor, Penov Gaši, Katarina, Sakač, Marija, Szabó, Nikoletta, Szécsi, Mihály   +10 more
core   +2 more sources

Merging Continuous Flow Technology, Photochemistry and Biocatalysis to Streamline Steroid Synthesis

Advanced Synthesis &Catalysis, Volume 365, Issue 23, Page 4024-4048, December 5, 2023., 2023
Abstract Since their structural elucidation in 1935, the introduction and substitution of functional groups and the modification of the steroidal scaffolds have been a fertile ground of research for synthetic and medicinal chemists. The discovery of steroids with hormonal and pharmacological activity has stimulated tremendous efforts to the development
Elena Tomarelli, Bruno Cerra, Francesco G. Mutti, Antimo Gioiello   +3 more
wiley   +1 more source

Engineering Mycobacterium smegmatis for testosterone production [PDF]

, 2016
11 p.-8 fig.-1 tab.A new biotechnological process for the production of testosterone (TS) has been developed to turn the model strain Mycobacterium smegmatis suitable for TS production to compete with the current chemical synthesis procedures.
Fernández-Cabezón, Lorena, Galán, Beatriz, García, José Luis   +2 more
core   +1 more source

The effect of sunscreen 4‐methylbenzylidene camphor in different and reproductive models, its bioaccumulation and molecular effects on ligand‐receptor interaction, and protein expression

Basic &Clinical Pharmacology &Toxicology, Volume 133, Issue 2, Page 130-141, August 2023., 2023
Abstract 4‐Methylbenzylidene camphor (4‐MBC) is a photo‐absorbing UV filter prevalently used in cosmetics, which can be absorbed into circulation and cause systemic effects. 4‐MBC is continued to be released in the environment despite the growing knowledge about its bioaccumulation and endocrine disrupting effects.
Cassandra Lax, Elin Wicksell, Anastasia Grip, Jenni Viivi Linnea Niemi, Wen Liu, Alexandra Rafeletou, Błażej Kudłak, Helgi B. Schiöth   +7 more
wiley   +1 more source

Evidence that androstadienone, a putative human chemosignal, modulates women’s attributions of men’s attractiveness [PDF]

, 2008
Considerable research effort has focused on whether specific compounds found within human body odor influence the behavior or physiology of other individuals.
Little, Anthony, Lyndon, Anna, Roberts, S. Craig, Saxton, Tamsin   +3 more
core   +3 more sources

Computational modeling studies reveal the origin of the binding preference of 3‐(3,4‐di hydroisoquinolin‐2(1H)‐ylsulfonyl)benzoic acids for AKR1C3 over its isoforms

Protein Science, Volume 31, Issue 12, December 2022., 2022
Abstract As a key regulator for hormone activity, human aldo‐keto reductase family 1 member C3 (AKR1C3) plays crucial roles in the occurrence of various hormone‐dependent or independent malignancies. It is a promising target for treating castration‐resistant prostate cancer (CRPC).
Xiaotian Kong, Enming Xing, Sijin Wu, Tony Zhuang, Pui‐Kai Li, Chunhua Li, Xiaolin Cheng   +6 more
wiley   +1 more source

Addressing recent challenges in isotope ratio mass spectrometry: Development of a method applicable to 1‐androstene‐steroids, 6α‐hydroxy‐androstenedione, and androstatrienedione

Drug Testing and Analysis, Volume 14, Issue 11-12, Page 1891-1903, November-December 2022., 2022
A method to determine the carbon isotope ratios of nine potentially pseudo‐endogenous steroids relevant to sports drug testing was developed and validated. Using established gas chromatography/combustion/isotope ratio mass spectrometry instrumentation, limits of quantification were determined at 10 ng/ml for a 20 ml urine aliquot for all analytes ...
Thomas Piper, Mario Thevis
wiley   +1 more source

Intermediates in 16‐androstene biosynthesis in neonatal porcine testis [PDF]

FEBS Letters, 1984
The metabolism of pregnenolone has been studied in microsomal preparations of testes from 3‐week old piglets. Metabolites identified after derivatization by capillary gas‐chromatography and further by combined gas chromatography‐mass spectrometry were: 17‐hydroxy‐ and 16α‐hydroxypregnenolone, dehydroepiandrosterone, 5‐androstenediols, 5‐pregnenediol ...
T K, Kwan, J W, Honour, N F, Taylor, D B, Gower   +3 more
openaire   +2 more sources

Sex pheromones are not always attractive: changes induced by learning and illness in mice [PDF]

, 2014
A male-specific major urinary protein named darcin is attractive to female mice, Mus musculus, stimulates a learned attraction to volatile components of a male's urinary odour and induces spatial learning. In this article we show that darcin also induces
Beynon, Robert J., Cádiz-Moretti, Bernardita, Fortes Marco, Lluís, Hernández Martínez, Adoración, Hurst, Jane L., Lanuza, Enrique, Marco Monclús, Pau, Martín Sánchez, Ana, Martínez García, Fernando, McLean, Lynn   +9 more
core   +2 more sources