Results 101 to 110 of about 35,287 (246)

The Longitudinal Effect of APOL1 Risk Alleles on Sickle Cell Anemia‐Associated Kidney Function

American Journal of Hematology, Volume 101, Issue 6, Page 1341-1350, June 2026.
ABSTRACT Progressive kidney injury is a major cause of morbidity and mortality in sickle cell anemia (SCA). The high risk APOL1 G1/G2 variants contribute to the development of kidney disease in individuals of African ancestry, including those with SCA.
Sara R. Rashkin, Guolian Kang, Clifford M. Takemoto, Mitchell J. Weiss, Kenneth I. Ataga, Santosh L. Saraf, Jeffrey Lebensburger, Rima S. Zahr   +7 more
wiley   +1 more source

Unusual Colonic Iron Deposition Following Prophylactic Supplementation in an Infant: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Iron plays a vital role in physiological functions, and its deposition is typically limited to reticuloendothelial tissues in the presence of excess levels. We report a rare case of colonic iron deposition in a 13‐month‐old child without iron overload or toxicity. Despite a normal serum iron profile and administration of only prophylactic iron
Farid Imanzadeh, Mohammad Mahdi Heidari, Seyyed Ramin Madani, Fatemeh Mahjoub, Somayyeh Jameie   +4 more
wiley   +1 more source

Apneia obstrutiva do sono em portadores da anemia falciforme Obstructive sleep apnea in sickle cell disease carriers

Revista Brasileira de Hematologia e Hemoterapia, 2010
A Síndrome da Apneia Obstrutiva do Sono (SAOS) é definida como episódios recorrentes de obstrução completa ou parcial das vias aéreas superiores que ocorrem durante o sono.
Cristina Salles, Regina T. T. Ramos, Marcos A. Matos   +2 more
doaj  

Intrathoracic Extramedullary Hematopoiesis Arising in the Anterior Mediastinum

Clinical Case Reports, Volume 14, Issue 6, June 2026.
Arrows indicate enlarging anterior (a, b) and posterior (c, d) mediastinal extramedullary hematopoiesis (EMH). EMH should be included in the differential diagnosis of anterior mediastinal lesion. Histologic confirmation is desirable to obtain definitive diagnosis and guide management.
Yoshiki Kozu, Tomoaki Kinno, Kazunori Kajino, Kenji Suzuki   +3 more
wiley   +1 more source

When Chronic Pain Clouds Acute Diagnosis: Femoral Shaft Osteonecrosis With Superimposed Pseudomonas Osteomyelitis in a Medically Complex Patient

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT In medically complex patients with chronic pain, new or worsening symptoms should prompt careful reassessment. Avascular necrosis, particularly in the setting of prolonged steroid use, may be overlooked due to diagnostic overshadowing. Timely recognition requires multidisciplinary collaboration and vigilance to distinguish acute pathology from
Ji‐Hoon Lee, Elias Lai, Jerry Markar, Bi Mo   +3 more
wiley   +1 more source

Immunotherapy 3.0: Breakthroughs Steering the Next Generation of Cancer Control

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Hematologic disorders, including sickle cell disease, anemias, hemoglobinopathies, leukemias, lymphomas, and bleeding disorders, constitute a substantial and growing burden of morbidity and mortality across Africa. Structural health system constraints—limited diagnostic capacity, shortages of trained hematology specialists ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Enhancing Interpretability and Explainability of Protein Function Prediction ML Model Using Explainable AI

Engineering Reports, Volume 8, Issue 6, June 2026.
This systematic review traces the evolution of protein function prediction from experimental methods through homology‐based tools, ML and DL to XAI. While deep learning models achieve state‐of‐the‐art predictive accuracy, their black‐box nature limits biological insight and clinical trust.
Aastha Katiyar, Rashmi Yadav
wiley   +1 more source

Nutritional Potential, Phytochemical Content, In Vivo Antioxidant, and Antanemic Potential of Musa paradisiaca Flower

Food Chemistry International, Volume 2, Issue 2, Page 246-262, June 2026.
After collecting Musa paradisiaca leaves, some were dried and others were used to produce aqueous extracts. The extracts and powders were characterized and then administered to rats made anaemic by PHZ. After 14 days of administration of the two samples, the rats were euthanized and it was observed that after 9 days of treatment, the aqueous extract ...
Josée Rebeca Nombo, Jethro Roland Misse Ngangue Ekwala, Somon Régine Tuem, Stéphano Tene Tambo, Merlin Ngafon Nchoutpouen, Valery Jean François Nsoga, Jules Christophe Koule Manz, Jordan Mekui Nwotue, Mathieu Ndomou   +8 more
wiley   +1 more source

EHA Recommendations for preconceptual and antenatal screening and prenatal diagnosis for hemoglobinopathies

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Thalassemia and sickle cell disease (SCD) are among the most common monogenic disorders worldwide. They cause chronic hemolytic anemia, the consequences and prognosis of which vary considerably depending on the genetic characteristics of patients and the healthcare system in their country of residence.
Mariane de Montalembert, Maria D. Cappellini, Achille Iolascon, Lucia de Franceschi, Eda Ömur, Michele Abi Saad, Immacolata Andolfo, Celeste Bento, Maria Berghs, Doris Bonnet, Andreas Glenthoj, Beatrice Gulbis, Tuphan K. Dolai, Jorge Lima, Irene Motta, Roberta Russo, Ali Taher, Leon Tshilolo, Antonio Almeida, David Rees   +19 more
wiley   +1 more source

Iptacopan monotherapy resulted in increased hemoglobin level in patients with PNH and hemoglobin ≥10 g/dL after anti‐C5 therapy

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Patients with paroxysmal nocturnal hemoglobinuria (PNH) on anti‐C5 often experience extravascular hemolysis with anemia. Iptacopan, the first oral proximal complement inhibitor targeting factor B, has shown efficacy and safety in PNH patients. APPULSE‐PNH (NCT05630001), a phase 3b, single‑arm, open‐label trial, enrolled adult patients with PNH
Austin Kulasekararaj, Flore S. de Fontbrune, Anna Gaya, Ilene Weitz, David J. Kuter, Bhumika J. Patel, David J. Araten, Abhay Singh, Jun H. Jang, Richard J. Kelly, Eros Di Bona, Michael Loschi, Vinod Pullarkat, Jörg Schubert, Rosario Notaro, Mustafa N. Yenerel, Joan Beckman, Nicolas Blin, Irina Murakhovskaya, Jens Panse, Eloy Roman, Alexander Röth, Hubert Schrezenmeier, Srinivas Tantravahi, Régis P. de Latour, Navin Mahajan, Luca Monaco, Tao Ding, Tomasz Lawniczek, Philippe Ferber, Marion Dahlke, Antonio M. Risitano   +31 more
wiley   +1 more source