Results 111 to 120 of about 205,200 (274)
Sickle cell anemia: An update on diagnosis, management and prevention strategies
Indian Journal of Community and Family Medicine, 2018 Sickle cell anemia is the most common disease entity of all the monogenic disorders. This is an autosomal recessive disorder. HbS polymerization, vaso-occlusion, and hemolytic anemia are central to the pathophysiology of sickle cell disease, they ...
Shruti Mishra, Gaurav Chhabra
doaj +1 more source
Survival Probability in Patients with Sickle Cell Anemia Using the Competitive Risk Statistical Model. [PDF]
, 2019 The clinical picture of patients with sickle cell anemia (SCA) is associated with several complications some of which could be fatal. The objective of this study is to analyze the causes of death and the effect of sex and age on survival of Brazilian ...
Ballas, Samir K. +3 more
core +1 more source
A century of theories of balancing selection
Biological Reviews, EarlyView.ABSTRACT Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short.
Filip Ruzicka +10 more
wiley +1 more source
Journal of Medical Case Reports, 2018 Background Posterior reversible encephalopathy syndrome is a neurotoxic condition that occurs as a result of the failure of posterior circulatory autoregulation in response to acute changes in blood pressure.
Ehab Hanafy +5 more
doaj +1 more source
Developmental Medicine &Child Neurology, EarlyView.Neurodevelopmental screening in toddlers or preschoolers with sickle cell disease (SCD) predicts future academic deficits. Screening sensitivity for future academic deficits is highest in preschoolers with SCD. Brief neurodevelopmental screening tools can identify high risk children for early intervention. Abstract Aim To assess the predictive validity
Sarah E. Bills +5 more
wiley +1 more source
Distal renal tubular acidosis in sickle cell anemia
Saudi Journal of Kidney Diseases and Transplantation, 2018 We report a rare case of two young male siblings with sickle cell anemia who presented with bilateral lower limb deformities, failure to thrive, polyuria, and polydipsia.
Anjali Bharani +3 more
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European Journal of Haematology, EarlyView.ABSTRACT Objectives Although Advancements in the Treatment of Hemoglobinopathies have Considerably Increased Life Expectancy, Hormonal and Pubertal Development Have Been Continuously Affected by Complications From Transfusion‐Related Iron Overload and Cytotoxic Therapies.
J. Dülberg +20 more
wiley +1 more source
Sexuality and sickle cell anemia
Revista Brasileira de Hematologia e Hemoterapia, 2013 BACKGROUND: Sickle cell disease, the most common hereditary blood disease in the world, is the result of an atypical hemoglobin called S (Hb S) which, when homozygous (Hb SS) is the cause of sickle cell anemia.
Viviane de Almeida Côbo +4 more
doaj
A Phase Ib open label, randomized, safety study of SANGUINATE™ in patients with sickle cell anemia
Revista Brasileira de Hematologia e HemoterapiaBackground: Treatment of sickle cell anemia is a challenging task and despite the well understood genetic and biochemical pathway of sickle hemoglobin, current therapy continues to be limited to the symptomatic treatment of pain, supplemental oxygen ...
Hemant Misra +7 more
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Association between hemolysis and albuminuria in adults with sickle cell anemia
Haematologica, 2012 Studies have questioned whether renal dysfunction in sickle cell disease is linked to hemolysis-associated vasculopathy. We have investigated renal function and markers of hemolysis in a cohort of 424 adult African-British patients with sickle cell ...
Thomas G. Day +4 more
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