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Annals of Internal Medicine, 1978
Excerpt To the editor: The "natural history" of sickle cell anemia in Saudi Arabs (Ann Intern Med88:1-6, 1978) is certainly different from the disease as we see it in the United States but not as d...
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Excerpt To the editor: The "natural history" of sickle cell anemia in Saudi Arabs (Ann Intern Med88:1-6, 1978) is certainly different from the disease as we see it in the United States but not as d...
openaire +2 more sources
2010
Sickle cell anemia (SCA or SS homozygous sickle cell disease) is an inherited blood disorder caused by single nucleotide substitution in the β-globin gene that renders their hemoglobin (HbS) much less soluble than normal hemoglobin (HbA) when deoxygenated. The polymerization of HbS upon deoxygenation is the basic pathophysiologic event leading
Connes Philippe +3 more
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Sickle cell anemia (SCA or SS homozygous sickle cell disease) is an inherited blood disorder caused by single nucleotide substitution in the β-globin gene that renders their hemoglobin (HbS) much less soluble than normal hemoglobin (HbA) when deoxygenated. The polymerization of HbS upon deoxygenation is the basic pathophysiologic event leading
Connes Philippe +3 more
openaire +1 more source
2014
Sickle cell anemia is one of the first diseases understood at the molecular level. Valine substituted for glutamic acid in the beta globin subunit leads to decreased solubility in the de-oxygenated state. It may partially protect infants from cerebral falciparum malaria in the heterozygous state (sickle trait), and geographic distribution of the ...
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Sickle cell anemia is one of the first diseases understood at the molecular level. Valine substituted for glutamic acid in the beta globin subunit leads to decreased solubility in the de-oxygenated state. It may partially protect infants from cerebral falciparum malaria in the heterozygous state (sickle trait), and geographic distribution of the ...
openaire +1 more source
Biologic and Clinical Efficacy of LentiGlobin for Sickle Cell Disease
New England Journal of Medicine, 2022Julie Kanter +2 more
exaly