Results 51 to 60 of about 205,200 (274)

Understanding Sickle cell disease: Causes, symptoms, and treatment options

Medicine, 2023
Sickle cell disease (SCD) is a hereditary blood disorder characterized by the production of abnormal hemoglobin molecules that cause red blood cells to take on a crescent or sickle shape.
Chukwuka Elendu, Dependable C. Amaechi, Chisom E Alakwe-Ojimba, T. C. Elendu, Rhoda C Elendu, Chiagozie P. Ayabazu, Titilayo O Aina, Ooreofe Aborisade, Joseph S Adenikinju   +8 more
semanticscholar   +1 more source

Acute Exercise Challenge and Airway Dynamics in Youth With Sickle Cell Anemia: A Multicenter Study

American Journal of Hematology, EarlyView.
Changes in airway dynamics in children with sickle cell anemia after maximal cardiopulmonary exercise testing and a controlled intensity interval excercise challenge. ABSTRACT Sickle cell anemia (SCA) leads to reduced physical functioning and cardiopulmonary fitness. Prior studies suggest that airway hyperresponsiveness to bronchoprovocation testing is
Robyn T. Cohen, Jane S. Hankins, Kirsten K. Ness, Lewis L. Hsu, Tracy Baynard, Amy Tang, Shlomit Radom‐Aizik, Kevin Guerrero, Mark Rodeghier, Robert I. Liem   +9 more
wiley   +1 more source

Erythropoiesis in health and disease: Distinguishing defective and ineffective erythropoiesis. [PDF]

Hemasphere
Abstract Erythropoiesis is a finely regulated process ensuring continuous red blood cell production to maintain oxygen delivery. Disruptions in this process give rise to defective erythropoiesis, characterized by impaired lineage commitment and progenitor development, and ineffective erythropoiesis (IE), marked by expansion of erythroid progenitors ...
El Hoss S, Lizarralde-Iragorri MA, Maciel TT, Hermine O.   +3 more
europepmc   +2 more sources

Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Slimane Allali, Nabiha Sbeih, Rachel Rignault‐Bricard, Johanna Bruce, Morgane Le Gall, Claire Heilbronner, Noemie de Cacqueray, Sofia Angyalosy, Melissa Taylor, Joséphine Brice, Mariane de Montalembert, Martina Bevacqua, Emilie‐Fleur Gautier, Olivier Hermine, Thiago Trovati Maciel   +14 more
wiley   +1 more source

Haptoglobin gene polymorphisms and interleukin-6 and -8 levels in patients with sickle cell anemia

Revista Brasileira de Hematologia e Hemoterapia, 2015
BACKGROUND: Haptoglobin genotypes, and interleukin-6 and -8 participate in the pathophysiology of sickle cell anemia. The expression of cytokines is regulated by genetic mechanisms however the effect of haptoglobin polymorphisms on these cytokines is not
Bruna Spinella Pierrot-Gallo, Perla Vicari, Sandra Satiko Matsuda, Samuel Ademola Adegoke, Grazielle Mecabo, Maria Stella Figueiredo   +5 more
doaj   +1 more source

Hematological and hemorheological determinants of the six-minute walk test performance in children with sickle cell anemia. [PDF]

PLoS ONE, 2013
The six-minute walk test is a well-established submaximal exercise reflecting the functional status and the clinical severity of sickle cell patients. The aim of the present cross-sectional study was to investigate the biological determinants of the six ...
Xavier Waltz, Marc Romana, Marie-Dominique Hardy-Dessources, Yann Lamarre, Lydia Divialle-Doumdo, Marie Petras, Vanessa Tarer, Régine Hierso, Kizzy-Clara Baltyde, Benoît Tressières, Marie-Laure Lalanne-Mistrih, Fréderic Maillard, Olivier Hue, Maryse Etienne-Julan, Philippe Connes   +14 more
doaj   +1 more source

Coexisting Sickle Cell Anemia and Sarcoidosis: A Management Conundrum! [PDF]

, 2017
Sickle cell disease and Sarcoidosis are conditions that are more common in the African American population. In this report we share an unfortunate patient who had hepatic sarcoidosis but could not receive steroids since that precipitated acute liver ...
Gollahalli, Nagesh S., Nutan, FNU
core   +3 more sources

Relationship between pulmonary and cardiac abnormalities in sickle cell disease: implications for the management of patients

Revista Brasileira de Hematologia e Hemoterapia, 2016
Objective: To evaluate the association between clinical, pulmonary, and cardiovascular findings in patients with sickle cell disease and, secondarily, to compare these findings between sickle cell anemia patients and those with other sickle cell diseases.
Maria Christina Paixão Maioli, Andrea Ribeiro Soares, Ricardo Bedirian, Ursula David Alves, Cirlene de Lima Marinho, Agnaldo José Lopes   +5 more
doaj   +1 more source

Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease [PDF]

, 2017
Key Points Regadenoson did not reduce iNKT cell activation to a prespecified level when administered to patients with SCD. Because iNKT cell activation was not reduced, the benefit of iNKT cell-based therapies in SCD cannot be determined.
Achebe, Maureen, Chu, Hillary, Field, Joshua J., George, Alex, Gordeuk, Victor R., Gowhari, Michel, Heeney, Matthew M., Hoppe, Carolyn, Lin, Gene, Linden, Joel, Majerus, Elaine, Nathan, David G., Neuberg, Donna, Puligandla, Maneka, Sheehan, Brian   +14 more
core   +2 more sources

Effect of Red Blood Cell Transfusion on Inflammatory and Angiogenic Pathways in Patients With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is a chronic inflammatory state, characterized by increased plasma values of inflammatory and angiogenic proteins. Although red blood cell (RBC) transfusion is known to have immunomodulatory effects in other conditions, its potential effects on the inflammatory state in SCD remain largely unknown.
Lydian A. de Ligt, Sanjay R. Thakoerdin, Maud Zwolsman, Gaby Stegemann, Hanke Matlung, Taco W. Kuijpers, Bart J. Biemond, Karin Fijnvandraat, Robin van Bruggen, Erfan Nur   +9 more
wiley   +1 more source