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Effect of general anesthetics on the developing brain
Journal of Anaesthesiology Clinical Pharmacology, 2012 Studies on rodents and subhuman primates suggest that prolonged exposure to general anesthetics may induce widespread neuronal cell death and neurological sequelae; seriously questioning the safety of pediatric anesthesia.
S Velayudha Reddy
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General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels. [PDF]
PLoS ONE, 2018 General anesthetics are indispensable for effective clinical care. Although, the mechanism of action of general anesthetics remains controversial, lipid bilayers and proteins have been discussed as their targets.
Jun-Ichi Kishikawa +7 more
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Effect of Local and General Anesthetics on Interfacial Water. [PDF]
PLoS ONE, 2016 Water undergoes structural change as it interfaces with hydrophilic surfaces, including the many hydrophilic surfaces within the cell. This interfacial water has become known as "Exclusion Zone (EZ) water" or "fourth-phase water" [1].We tested the ...
Nenad Kundacina +2 more
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Inhaled anesthetics : environmental role, occupational risk, and clinical use [PDF]
Journal of Clinical Medicine, 2021 Inhaled anesthetics have been in clinical use for over 150 years and are still commonly used in daily practice. The initial view of inhaled anesthetics as indispensable for general anesthesia has evolved during the years and, currently, its general use ...
Gaya da Costa, Mariana +2 more
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The Effects of General Anesthetics on Synaptic Transmission
Current Neuropharmacology, 2020 General anesthetics are a class of drugs that target the central nervous system and are widely used for various medical procedures. General anesthetics produce many behavioral changes required for clinical intervention, including amnesia, hypnosis, analgesia, and immobility; while they may also induce side effects like respiration and cardiovascular ...
Hui Yang +9 more
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Effects of general anesthetics on visceral pain transmission in the spinal cord [PDF]
Molecular Pain, 2008 Current evidence suggests an analgesic role for the spinal cord action of general anesthetics; however, the cellular population and intracellular mechanisms underlying anti-visceral pain by general anesthetics still remain unclear.
Yue Yun +5 more
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Neural Regeneration Research, 2017 Postoperative cognitive dysfunction (POCD) is a multifactorial process with a huge number of predisposing, causal, and precipitating factors. In this scenario, the neuroinflammation and the microglial activation play a pivotal role by triggering and ...
Marco Cascella, Sabrina Bimonte
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Binding Site and Affinity Prediction of General Anesthetics to Protein Targets Using Docking [PDF]
Anesthesia and Analgesia, 2012 BACKGROUND: The protein targets for general anesthetics remain unclear. A tool to predict anesthetic binding for potential binding targets is needed.
Liang, David +3 more
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General anesthetic action profile on the human prefrontal cortex cells through comprehensive single-cell RNA-seq analysis [PDF]
iScience, 2023 Summary: The cellular and molecular actions of general anesthetics to induce anesthesia state and also cellular signaling changes for subsequent potential “long term” effects remain largely elusive.
Enqiang Chang +26 more
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Mechanisms of action of general anesthetics
Frontiers in Bioscience, 2014 Since William Morton successfully demonstrated the use of inhaled ether for surgical anesthesia in 1846, the development of new anesthetics and safe general anesthesia techniques have contributed greatly to the advancement of surgery and other invasive procedures. However, the underlying neurocellular mechanisms by which the state of general anesthesia
Peirong Liu +4 more
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