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Effect of general anesthetics on the developing brain
Journal of Anaesthesiology Clinical Pharmacology, 2012 Studies on rodents and subhuman primates suggest that prolonged exposure to general anesthetics may induce widespread neuronal cell death and neurological sequelae; seriously questioning the safety of pediatric anesthesia.
S Velayudha Reddy
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General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels. [PDF]
PLoS ONE, 2018 General anesthetics are indispensable for effective clinical care. Although, the mechanism of action of general anesthetics remains controversial, lipid bilayers and proteins have been discussed as their targets.
Jun-Ichi Kishikawa +7 more
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Effect of Local and General Anesthetics on Interfacial Water. [PDF]
PLoS ONE, 2016 Water undergoes structural change as it interfaces with hydrophilic surfaces, including the many hydrophilic surfaces within the cell. This interfacial water has become known as "Exclusion Zone (EZ) water" or "fourth-phase water" [1].We tested the ...
Nenad Kundacina +2 more
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The Effects of General Anesthetics on Synaptic Transmission
Current Neuropharmacology, 2020 General anesthetics are a class of drugs that target the central nervous system and are widely used for various medical procedures. General anesthetics produce many behavioral changes required for clinical intervention, including amnesia, hypnosis, analgesia, and immobility; while they may also induce side effects like respiration and cardiovascular ...
Hui Yang +9 more
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Neural Regeneration Research, 2017 Postoperative cognitive dysfunction (POCD) is a multifactorial process with a huge number of predisposing, causal, and precipitating factors. In this scenario, the neuroinflammation and the microglial activation play a pivotal role by triggering and ...
Marco Cascella, Sabrina Bimonte
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Mechanisms of action of general anesthetics
Frontiers in Bioscience, 2014 Since William Morton successfully demonstrated the use of inhaled ether for surgical anesthesia in 1846, the development of new anesthetics and safe general anesthesia techniques have contributed greatly to the advancement of surgery and other invasive procedures. However, the underlying neurocellular mechanisms by which the state of general anesthesia
Peirong Liu +4 more
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General anesthetics inhibit LPS-induced IL-1β expression in glial cells. [PDF]
PLoS ONE, 2013 BACKGROUND: Glial cells, including microglia and astrocytes, are considered the primary source of proinflammatory cytokines in the brain. Immune insults stimulate glial cells to secrete proinflammatory cytokines that modulate the acute systemic response,
Tomoharu Tanaka +5 more
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General Anesthetics: Aspects of Chirality, Pharmacodynamics, and Pharmacokinetics [PDF]
PharmaceuticalsThe introduction of general anesthetics in the mid-19th century is considered one of the greatest contributions to medical practice. It was the first time that complicated surgical interventions became feasible, without putting an excessive strain on the
Ružena Čižmáriková +2 more
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How general anesthetics work: from the perspective of reorganized connections within the brain [PDF]
Korean Journal of Anesthesiology, 2022 General anesthesia is critical for various procedures and surgeries. Despite the widespread use of anesthetics, their precise mechanisms remain poorly understood.
Teo Jeon Shin +2 more
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Cancers, 2023 Simple Summary This meta-analysis examined the effect of general anesthetics on metastasis and recurrence after cancer surgery from clinical and pre-clinical studies.
Ru Li +7 more
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