Results 121 to 130 of about 98,175 (301)

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

A Robust Bio‐Supportive Hydrogel Patch for Full‐Thickness Repair of Gastroesophageal Defects

Advanced Science, EarlyView.
Gastroesophageal defect repair remains a formidable clinical challenge plagued by high leakage and life‐threatening complications. We develop a double‐disc, highly crystalline PVA‐based RBS hydrogel patch featuring suture‐free sealing, robust acid/enzyme resistance and mechanical durability.
Xingqi Song, Zhewei Shuai, Weiyan Sun, Liang Chen, Yiwei Shen, Jiateng Hu, Yuanqi Ma, Jie Luo, Meilin Huang, Yan Luo, Yunlang She, Guangdong Zhou, Chang Chen, Dong Lei   +13 more
wiley   +1 more source

Inhalation anesthetics from the point of chemical safety in surgery

, 2016
На сегодняшний день хирургическая активность достаточно высока и требует адекватного Анеса-тезиологичного обеспечения. Для достижения этой цели врач анестезиолог использует в своей практике несколько лекарственных средств с различным механизмом действия,
Салех, Е. Н., Салех, О. Н., Salekh, E. N.   +2 more
core  

Effects of repeat exposure to inhalation anesthetics on liver and renal function

, 2013
Background: Cross hypersensitivity to inhalation anesthetics has not been studied. The aim of this study was to investigate it by comparing liver and renal function after repeated anesthesia with sevoflurane and isoflurane retrospectively.
Tomoki Nishiyama
core   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Comparison OF the Effect OF Inhalation Anesthetics (Sevoflurane AND Isoflurane) on Hemodynamic Parameters in Patients During General Anesthesia

Inhalation anesthetics such as sevoflurane and isoflurane are widely used in clinical practice due to their controllability, high efficacy, and relatively rapid recovery after surgery. However, their impact on hemodynamics during anesthesia is a critical
S, M. R. (Muralimova), F, R. Z. (Ramazanova)   +1 more
core  

E-cigarettes: Learnings for inhalation scientists: How studying e-cigarette technology may lead to new inhalation therapies

, 2016
ECs share a common purpose with conventional pharmaceutical inhalation devices: they produce aerosols intended to be orally inhaled into the respiratory tract.
Kwok, PCL, Hou, L, Rogueda, P
core  

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Chronic exposure to inhalation anesthetics and immunity

, 1992
The existence of a professional disease caused by exposure to general anesthetics has been reported by a number of studies, but opinions still differ as to the effective implications of this type of exposure.
DE MEDICI M, CONSOLI P, DE NICOLA A, COLANGELI A., PURPURA M, DAMIANI C, PIROLI, ALBA, CAMILLI GIAMMEI T, MANNELLA E, ROSCI G   +9 more
core  

Inhalational Anesthetic

Bangabandhu Sheikh Mujib Medical College Journal
Abstract not available Bangabandhu Sheikh Mujib Med. Coll. J.
openaire   +1 more source