Results 31 to 40 of about 755,676 (359)

High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]

, 2018
BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E., Dai, Jennifer B., Daigle, Renee, Forman, Stuart A., Halpin, Elizabeth S., Jounaidi, Youssef, Marte-Oquendo, Francisco, Porco, John A., Schaus, Scott E., Trilles, Richard, Xu, Wenqing, Yang, Xiaoxuan, Yu, Buwei   +12 more
core   +1 more source

The role of Volatile Anesthetics in Cardioprotection: a systematic review. [PDF]

, 2012
This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage.
Applegate, Richard L, Krafft, Paul R, Leitzke, Arthur S, Tang, Jiping, Van Allen, Nicole R, Zhang, John H   +5 more
core   +1 more source

Maternal analgosedation and breastfeeding: guidance for the pediatrician

Journal of Pediatric and Neonatal Individualized Medicine, 2015
As part of analgosedative treatment modalities after delivery (e.g. caesarean related pain, birth related trauma, pre-existing pain syndromes), mothers are treated with different analgosedatives that may also affect the nursing infant.
Karel Allegaert, Johannes N. van den Anker   +1 more
doaj   +1 more source

NF‐kB signaling in cardiomyocytes is inhibited by sevoflurane and promoted by propofol

FEBS Open Bio, 2020
Both inhalational and intravenous anesthetics affect myocardial remodeling, but the precise effect of each anesthetic on molecular signaling in myocardial remodeling is unknown.
Keiko Oda‐Kawashima, Anna S. Sedukhina, Naoki Okamoto, Mariya lytvyn, Kimino Minagawa, Teppei Iwata, Toshio Kumai, Eri Sato, Eiichi Inada, Ayako Yamaura, Miki Sakamoto, Marta Roche‐Molina, Juan A. Bernal, Ko Sato   +13 more
doaj   +1 more source

Anesthetics and long-term survival after cancer surgery—total intravenous versus volatile anesthesia: a retrospective study

BMC Anesthesiology, 2019
BackgroundIntravenous anesthesia has been reported to have a favorable effect on the prognosis of cancer patients. This study was performed to analyze data regarding the relation between anesthetics and the prognosis of cancer patients in our hospital ...
B. Hong, Sunyeul Lee, Yeojung Kim, Minhee Lee, A. Youn, Hyun Rhim, Seokhwan Hong, Y. Kim, S. Yoon, C. Lim   +9 more
semanticscholar   +1 more source

Intravenous ganaxolone for the treatment of refractory status epilepticus: Results from an open‐label, dose‐finding, phase 2 trial

Epilepsia, 2022
Patients with refractory status epilepticus (RSE) have failed treatment with benzodiazepines and ≥1 second‐line intravenous (IV) antiseizure medication (ASM).
H. Vaitkevicius, R. Ramsay, Christa B. Swisher, A. Husain, A. Aimetti, M. Gąsior   +5 more
semanticscholar   +1 more source

Volatile anesthetics versus total intravenous anesthesia in patients undergoing coronary artery bypass grafting: An updated meta-analysis and trial sequential analysis of randomized controlled trials

PLoS ONE, 2019
Background The benefits of volatile anesthetics in coronary artery bypass grafting (CABG) patients remain controversial. We aimed to conduct an updated meta-analysis to assess whether the use of volatile anesthetics during CABG could reduce mortality and
X. Jiao, Xue-mei Lin, X. Ni, Hailong Li, Chuan Zhang, Chun-song Yang, Hao-Xin Song, Qiusha Yi, Ling-Li Zhang   +8 more
semanticscholar   +1 more source

INHALATION SEDATION IN THE PATIENTS AFTER CARDIAC SURGERY IN INTENSIVE CARE UNITS

Вестник анестезиологии и реаниматологии, 2018
From the time when special tools for delivery of volatile anesthetics in the intensive care units (ICU) became available, inhalation sedation is getting more and more popular among emergency physicians.
V. V. Likhvantsev, O. A. Grebenchikov, Yu. V. Skripkin, O. N. Ulitkina, F. F. Bershadskiy, E. M. Stroiteleva   +5 more
doaj   +1 more source

Intravenous versus Volatile Anesthetic Effects on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Abdominal Surgery.

Anesthesiology, 2021
BACKGROUND Delayed neurocognitive recovery after surgery is associated with poor outcome. Most surgeries require general anesthesia, of which sevoflurane and propofol are the most commonly used inhalational and intravenous anesthetics. The authors tested
Yujuan Li, Dongtai Chen, Han-bing Wang, Zhi Wang, Furong Song, Hui Li, L. Ling, Zhiwen Shen, Chuwen Hu, Jun Peng, Wei-Xing Li, W. Xing, Jiahao Pan, Hua-geng Liang, Qiao-ling Zhou, J. Cai, Ziqing He, S. Peng, W. Zeng, Zhiyi Zuo   +19 more
semanticscholar   +1 more source

Lipid Emulsion for Local Anesthetic Systemic Toxicity

Anesthesiology Research and Practice, 2012
The accidental overdose of local anesthetics may prove fatal. The commonly used amide local anesthetics have varying adverse effects on the myocardium, and beyond a certain dose all are capable of causing death.
Sarah Ciechanowicz, Vinod Patil
doaj   +1 more source