Results 41 to 50 of about 108,411 (239)
Continuous Flow Synthesis of Propofol
Molecules, 2021 Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol—also known as Propofol—a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis.
Romain Mougeot +3 more
doaj +1 more source
Liquid general anesthetics lower critical temperatures in plasma membrane vesicles [PDF]
, 2013 A large and diverse array of small hydrophobic molecules induce general anesthesia. Their efficacy as anesthetics has been shown to correlate both with their affinity for a hydrophobic environment and with their potency in inhibiting certain ligand gated ion channels.
arxiv +1 more source
Stabilizing membrane domains antagonizes n-alcohol anesthesia [PDF]
Biophysical Journal, Volume 111, Issue 3, 9 August 2016, Pages
537-545, 2016 Diverse molecules induce general anesthesia with potency strongly correlated both with their hydrophobicity and their effects on certain ion channels. We recently observed that several n-alcohol anesthetics inhibit heterogeneity in plasma membrane derived vesicles by lowering the critical temperature ($T_c$) for phase separation.
arxiv +1 more source
On the action potential as a propagating density pulse and the role of anesthetics [PDF]
Biophys. Rev. Letters 2 (2007) 57-78, 2006 The Hodgkin-Huxley model of nerve pulse propagation relies on ion currents through specific resistors called ion channels. We discuss a number of classical thermodynamic findings on nerves that are not contained in this classical theory. Particularly striking is the finding of reversible heat changes, thickness and phase changes of the membrane during ...
arxiv +1 more source
The thermodynamics of lipid ion channel formation in the absence and presence of anesthetics. BLM experiments and simulations [PDF]
Soft Matter, 2009, 5: 3319-3330, 2009 It is known that lipid membranes become permeable in their melting regime. In microscopic conductance measurements on black lipid membranes one finds that conduction takes place via quantized events closely resembling those reported for protein ion channels. Here, we present data of ion currents through black lipid membranes in the presence and absence
arxiv +1 more source
The free energy of biomembrane and nerve excitation and the role of anesthetics [PDF]
BBA - Biomembranes 1860 (2018) 2145-2153, 2018 In the electromechanical theory of nerve stimulation, the nerve impulse consists of a traveling region of solid membrane in a liquid environment. Therefore, the free energy necessary to stimulate a pulse is directly related to the free energy difference necessary to induce a phase transition in the nerve membrane.
arxiv +1 more source
Scientific ReportsThe inspired sinewave technique (IST) is a non-invasive method to measure lung heterogeneity indices (including both uneven ventilation and perfusion or heterogeneity), which reveal multiple conditions of the lung and lung injury.
Minh C. Tran +8 more
doaj +1 more source