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Current Biology, 2015 The terms 'haploid' and 'diploid' that describe single (n) and double (2n) chromosome sets in cells were coined by the Polish-German botanist Eduard Strasburger and originate from the Greek terms haplóos meaning 'single' and diplóos meaning 'double'.
Orr, Bernardo +2 more
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Frontiers in Cell and Developmental Biology, 2022 Aneuploidy is widely identified as a remarkable feature of malignancy genomes. Increasing evidences suggested aneuploidy was involved in the progression and metastasis of prostate cancer (PCa). Nevertheless, no comprehensive analysis was conducted in PCa
Yun Peng, Yuxuan Song, Haitao Wang
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Frontiers in Immunology, 2022 Chromosome instability (CIN) and its major consequence, aneuploidy, are hallmarks of human cancers. In addition to imposing fitness costs on tumor cells through several cell-intrinsic mechanisms, CIN/aneuploidy also provokes an antitumor immune response.
Xiaohong Kuang, Jian Li
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Understanding How Genetic Mutations Collaborate with Genomic Instability in Cancer
Cells, 2021 Chromosomal instability is the process of mis-segregation for ongoing chromosomes, which leads to cells with an abnormal number of chromosomes, also known as an aneuploid state.
Laura J. Jilderda +2 more
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Cold Spring Harbor Symposia on Quantitative Biology, 2010 Aneuploidy refers to karyotypic abnormalities characterized by gain or loss of individual chromosomes. This condition is associated with disease and death in all organisms in which it has been studied. We have characterized the effects of aneuploidy on yeast and primary mouse cells and found it to be detrimental at the cellular level.
Torres Mejia, Elen Raquel Sarabasti +3 more
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Causes, consequences and clinical significance of aneuploidy across melanoma subtypes
Frontiers in Oncology, 2022 Aneuploidy, the state of the cell in which the number of whole chromosomes or chromosome arms becomes imbalanced, has been recognized as playing a pivotal role in tumor evolution for over 100 years.
Eva R. Shteinman +20 more
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Exploiting aneuploidy-imposed stresses and coping mechanisms to battle cancer [PDF]
Open Biology, 2020 Aneuploidy, an irregular number of chromosomes in cells, is a hallmark feature of cancer. Aneuploidy results from chromosomal instability (CIN) and occurs in almost 90% of all tumours.
Lin Zhou +2 more
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Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?
Stem Cells Translational Medicine, 2020 The demand for an efficient therapy for alopecia disease has fueled the hair research field in recent decades. However, despite significant improvements in the knowledge of key processes of hair follicle biology such as genesis and cycling, translation ...
Ana Rita Castro, Elsa Logarinho
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Aneuploidy and tumorigenesis [PDF]
Seminars in Cell & Developmental Biology, 2011 Aneuploidy is a prominent phenotype of cancer. It refers to deviations from the normal number of chromosomes in a cell, as a result of whole-chromosome loss or gain. In most cases, aneuploidy is caused by mitotic errors due to defects in the mechanisms that have evolved to ensure faithful chromosome segregation, such as the spindle assembly checkpoint (
Xiao Fang, Pumin Zhang
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Mouse Models of Aneuploidy [PDF]
The Scientific World Journal, 2012 Abnormalities of chromosome copy number are called aneuploidies and make up a large health load on the human population. Many aneuploidies are lethal because the resulting abnormal gene dosage is highly deleterious. Nevertheless, some whole chromosome aneuploidies can lead to live births. Alterations in the copy number of sections of chromosomes, which
Olivia Sheppard +4 more
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