Results 1 to 10 of about 95,739 (341)

Chromosomal instability in human trophoblast stem cells and placentas [PDF]

Nature Communications
The human placenta, a unique tumor-like organ, is thought to exhibit rare aneuploidy associated with adverse pregnancy outcomes. Discrepancies in reported aneuploidy prevalence in placentas stem from limitations in modeling and detection methods.
Danyang Wang, Andrew Cearlock, Katherine Lane, Chongchong Xu, Ian Jan, Stephen McCartney, Ian Glass, Rajiv McCoy, Min Yang   +8 more
doaj   +2 more sources

Systematic Elucidation of the Aneuploidy Landscape and Identification of Aneuploidy Driver Genes in Prostate Cancer

Frontiers in Cell and Developmental Biology, 2022
Aneuploidy is widely identified as a remarkable feature of malignancy genomes. Increasing evidences suggested aneuploidy was involved in the progression and metastasis of prostate cancer (PCa). Nevertheless, no comprehensive analysis was conducted in PCa
Yun Peng, Yuxuan Song, Haitao Wang
doaj   +1 more source

Chromosome instability and aneuploidy as context-dependent activators or inhibitors of antitumor immunity

Frontiers in Immunology, 2022
Chromosome instability (CIN) and its major consequence, aneuploidy, are hallmarks of human cancers. In addition to imposing fitness costs on tumor cells through several cell-intrinsic mechanisms, CIN/aneuploidy also provokes an antitumor immune response.
Xiaohong Kuang, Jian Li
doaj   +1 more source

Understanding How Genetic Mutations Collaborate with Genomic Instability in Cancer

Cells, 2021
Chromosomal instability is the process of mis-segregation for ongoing chromosomes, which leads to cells with an abnormal number of chromosomes, also known as an aneuploid state.
Laura J. Jilderda, Lin Zhou, Floris Foijer   +2 more
doaj   +1 more source

Causes, consequences and clinical significance of aneuploidy across melanoma subtypes

Frontiers in Oncology, 2022
Aneuploidy, the state of the cell in which the number of whole chromosomes or chromosome arms becomes imbalanced, has been recognized as playing a pivotal role in tumor evolution for over 100 years.
Eva R. Shteinman, Eva R. Shteinman, Eva R. Shteinman, James S. Wilmott, James S. Wilmott, James S. Wilmott, Ines Pires da Silva, Ines Pires da Silva, Ines Pires da Silva, Ines Pires da Silva, Georgina V. Long, Georgina V. Long, Georgina V. Long, Georgina V. Long, Richard A. Scolyer, Richard A. Scolyer, Richard A. Scolyer, Richard A. Scolyer, Ismael A. Vergara, Ismael A. Vergara, Ismael A. Vergara   +20 more
doaj   +1 more source

Exploiting aneuploidy-imposed stresses and coping mechanisms to battle cancer [PDF]

Open Biology, 2020
Aneuploidy, an irregular number of chromosomes in cells, is a hallmark feature of cancer. Aneuploidy results from chromosomal instability (CIN) and occurs in almost 90% of all tumours.
Lin Zhou, Laura J. Jilderda, Floris Foijer   +2 more
doaj   +1 more source

Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?

Stem Cells Translational Medicine, 2020
The demand for an efficient therapy for alopecia disease has fueled the hair research field in recent decades. However, despite significant improvements in the knowledge of key processes of hair follicle biology such as genesis and cycling, translation ...
Ana Rita Castro, Elsa Logarinho
doaj   +1 more source

Recombining your way out of trouble: the genetic architecture of hybrid fitness under environmental stress [PDF]

, 2020
Hybridization between species is a fundamental evolutionary force that can both promote and delay adaptation. There is a deficit in our understanding of the genetic basis of hybrid fitness, especially in non-domesticated organisms.
Bendixsen, D., Greig, D., Janzen, T., Nolte, A., Stelkens, R., Zhang, Z.   +5 more
core   +1 more source

Stem-Like Adaptive Aneuploidy and Cancer Quasispecies [PDF]

, 2013
We analyze and reinterpret experimental evidence from the literature to argue for an ability of tumor cells to self-regulate their aneuploidy rate. We conjecture that this ability is mediated by a diversification factor that exploits molecular mechanisms
Napoletani, Domenico, Signore, Michele, Struppa, Daniele C.   +2 more
core   +4 more sources

Non-immune fetal hydrops: etiology and outcome according to gestational age at diagnosis. [PDF]

, 2020
OBJECTIVE: Fetal hydrops is associated with increased perinatal morbidity and mortality. The etiology and outcome of fetal hydrops may differ according to the gestational age at diagnosis.
A. Bhide, A. Khalil, A. Kulkarni, B. Thilaganathan, E. Dempsey, F. G. Sileo, Hutchison AA, I. Branescu, Jauniaux E, Norton ME, S. Mansour, Santolaya J, T. Homfray   +12 more
core   +2 more sources