Results 1 to 10 of about 45,778 (235)
Incidence of aneuploidy in embryos studied using PGT-A in Mexico: a clinical retrospective experience [PDF]
Revista Brasileira de Ginecologia e ObstetríciaObjective: This study aimed to analyze the relationship between aneuploidy and maternal age based on preimplantation genetic testing for aneuploidies (PGT-A) and the distribution of aneuploidy across individual chromosomes.
Eduardo Ponce-Najera +7 more
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Frontiers in Cell and Developmental Biology, 2022 Aneuploidy is widely identified as a remarkable feature of malignancy genomes. Increasing evidences suggested aneuploidy was involved in the progression and metastasis of prostate cancer (PCa). Nevertheless, no comprehensive analysis was conducted in PCa
Yun Peng, Yuxuan Song, Haitao Wang
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Frontiers in Immunology, 2022 Chromosome instability (CIN) and its major consequence, aneuploidy, are hallmarks of human cancers. In addition to imposing fitness costs on tumor cells through several cell-intrinsic mechanisms, CIN/aneuploidy also provokes an antitumor immune response.
Xiaohong Kuang, Jian Li
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Understanding How Genetic Mutations Collaborate with Genomic Instability in Cancer
Cells, 2021 Chromosomal instability is the process of mis-segregation for ongoing chromosomes, which leads to cells with an abnormal number of chromosomes, also known as an aneuploid state.
Laura J. Jilderda +2 more
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Causes, consequences and clinical significance of aneuploidy across melanoma subtypes
Frontiers in Oncology, 2022 Aneuploidy, the state of the cell in which the number of whole chromosomes or chromosome arms becomes imbalanced, has been recognized as playing a pivotal role in tumor evolution for over 100 years.
Eva R. Shteinman +20 more
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Exploiting aneuploidy-imposed stresses and coping mechanisms to battle cancer [PDF]
Open Biology, 2020 Aneuploidy, an irregular number of chromosomes in cells, is a hallmark feature of cancer. Aneuploidy results from chromosomal instability (CIN) and occurs in almost 90% of all tumours.
Lin Zhou +2 more
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Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?
Stem Cells Translational Medicine, 2020 The demand for an efficient therapy for alopecia disease has fueled the hair research field in recent decades. However, despite significant improvements in the knowledge of key processes of hair follicle biology such as genesis and cycling, translation ...
Ana Rita Castro, Elsa Logarinho
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FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
Nature Communications, 2018 Evidence for mitotic decline in aged cells and for aneuploidy-driven progression into full senescence is limited. Here, the authors find that in aged cells, mitotic gene repression leads to increased chromosome mis-segregation and aneuploidy that ...
Joana Catarina Macedo +9 more
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Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability
Nature Communications, 2017 Recent findings suggest that forces acting on the cell nucleus can cause DNA damage, but the mechanisms are unclear. Here Takakiet al. report that actomyosin is a determinant of nuclear shape and that unrestrained contractility elicits nuclear envelope ...
Tohru Takaki +10 more
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PLoS Biology, 2019 Studying aneuploidy during organism development has strong limitations because chronic mitotic perturbations used to generate aneuploidy usually result in lethality.
Mihailo Mirkovic +4 more
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