Results 21 to 30 of about 93,321 (331)

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

Nature Communications, 2018
Evidence for mitotic decline in aged cells and for aneuploidy-driven progression into full senescence is limited. Here, the authors find that in aged cells, mitotic gene repression leads to increased chromosome mis-segregation and aneuploidy that ...
Joana Catarina Macedo, Sara Vaz, Bjorn Bakker, Rui Ribeiro, Petra Lammigje Bakker, Jose Miguel Escandell, Miguel Godinho Ferreira, René Medema, Floris Foijer, Elsa Logarinho   +9 more
doaj   +1 more source

Aneuploidy and confined chromosomal mosaicism in the developing human brain. [PDF]

PLoS ONE, 2007
BACKGROUND: Understanding the mechanisms underlying generation of neuronal variability and complexity remains the central challenge for neuroscience.
Yuri B Yurov, Ivan Y Iourov, Svetlana G Vorsanova, Thomas Liehr, Alexei D Kolotii, Sergei I Kutsev, Franck Pellestor, Alfia K Beresheva, Irina A Demidova, Viktor S Kravets, Viktor V Monakhov, Ilia V Soloviev   +11 more
doaj   +1 more source

Errors in chromosome segregation during oogenesis and early embryogenesis [PDF]

, 2010
Errors in chromosome segregation occurring during human oogenesis and early embryogenesis are very common. Meiotic chromosome development during oogenesis is subdivided into three distinct phases.
A Dyban, A Kuliev, A Kuliev, A Mantzouratou, A Pujol, AL Barlow, C Gutierrez-Mateo, C Gutierrez-Mateo, C Staessen, C Tease, C Tease, C Tease, C Yuncken, CM Conn, CM Conn, D Wells, D Wells, E Bendsen, E Fragouli, E Fragouli, E Fragouli, E Fragouli, E Iwarsson, EY Cheng, F Pellestor, F Pellestor, G Sher, HE Hall, J Cohen, J Cozzi, JD Delhanty, JD Delhanty, JD Delhanty, JD Delhanty, KT Jones, L Gianaroli, L Gras, L Voullaire, L Voullaire, L Wilton, M Hultén, M Sandalinas, M Simopoulou, MA Hultén, ML Lenzi, NV Kovaleva, P Platteau, PA Almeida, PA Hunt, R Angell, R Mahmood, S Cupisti, S Evsikov, S Mastenbroek, S Munné, S Munné, S Munné, S Munné, S Munné, S Munné, S Munné, S Munné, T Anahory, T Hassold, TR Oliver, Y Verlinsky   +65 more
core   +1 more source

Non-immune fetal hydrops: etiology and outcome according to gestational age at diagnosis. [PDF]

, 2020
OBJECTIVE: Fetal hydrops is associated with increased perinatal morbidity and mortality. The etiology and outcome of fetal hydrops may differ according to the gestational age at diagnosis.
A. Bhide, A. Khalil, A. Kulkarni, B. Thilaganathan, E. Dempsey, F. G. Sileo, Hutchison AA, I. Branescu, Jauniaux E, Norton ME, S. Mansour, Santolaya J, T. Homfray   +12 more
core   +2 more sources

Aneuploidy in Cancer and Aging [PDF]

Annual Review of Genetics, 2016
Chromosomal instability (CIN), the persistent inability of a cell to faithfully segregate its genome, is a feature of many cancer cells. It stands to reason that CIN enables the acquisition of multiple cancer hallmarks; however, there is a growing body of evidence suggesting that CIN impairs cellular fitness and prevents neoplastic transformation ...
Naylor, R.M., Deursen, J.M.A. van
openaire   +4 more sources

Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

Nature Communications, 2017
Recent findings suggest that forces acting on the cell nucleus can cause DNA damage, but the mechanisms are unclear. Here Takakiet al. report that actomyosin is a determinant of nuclear shape and that unrestrained contractility elicits nuclear envelope ...
Tohru Takaki, Marco Montagner, Murielle P. Serres, Maël Le Berre, Matt Russell, Lucy Collinson, Karoly Szuhai, Michael Howell, Simon J. Boulton, Erik Sahai, Mark Petronczki   +10 more
doaj   +1 more source

Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness

Nature Communications, 2022
Aneuploidy results in decreased cellular fitness in many species and model systems. However, aneuploidy is commonly found in cancer cells and often correlates with aggressive growth, suggesting that the impact of aneuploidy on cellular fitness is context
Federica Schiavoni, Pedro Zuazua-Villar, Theodoros I. Roumeliotis, Graeme Benstead-Hume, Mercedes Pardo, Frances M. G. Pearl, Jyoti S. Choudhary, Jessica A. Downs   +7 more
doaj   +1 more source

How to Survive Aneuploidy [PDF]

Cell, 2010
Aneuploidy, or an abnormal number of chromosomes, adversely affects cell growth, but it is also linked with cancer and tumorigenesis. Now, Torres et al. (2010) help to resolve this paradox by demonstrating that aneuploid yeast cells can evolve mutations in the proteasome protein degradation pathway that alleviate imbalances in protein production and ...
Don W. Cleveland, Bulent Cetin
openaire   +3 more sources

Modulation of Aneuploidy in Leishmania donovani during Adaptation to Different In Vitro and In Vivo Environments and Its Impact on Gene Expression

mBio, 2017
Aneuploidy is usually deleterious in multicellular organisms but appears to be tolerated and potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major protozoan parasite, is emerging as a new model for aneuploidy, since in
F. Dumetz, H. Imamura, M. Sanders, V. Seblova, J. Myskova, P. Pescher, M. Vanaerschot, C. J. Meehan, B. Cuypers, G. De Muylder, G. F. Späth, G. Bussotti, J. R. Vermeesch, M. Berriman, J. A. Cotton, P. Volf, J. C. Dujardin, M. A. Domagalska   +17 more
doaj   +1 more source

Pregnancy outcome following prenatal diagnosis of chromosomal anomaly: a record linkage study of 26,261 pregnancies [PDF]

, 2016
Previous studies have demonstrated the influence of changes in the age at which women give birth, and of developments in prenatal screening and diagnosis on the number of pregnancies diagnosed and terminated with chromosomal anomalies.
Cooper, Sally-Ann, Jacobs, Myrthe, McGowan, Ruth, Nelson, Scott, Pell, Jill P.   +4 more
core   +1 more source