Results 21 to 30 of about 50,865 (308)
Aneuploidy facilitates dysplastic and tumorigenic phenotypes in the Drosophila gut
Biology Open, 2021 Aneuploidy has been strongly linked to cancer development, and published evidence has suggested that aneuploidy can have an oncogenic or a tumor suppressor role depending on the tissue context.
Rita Brás +3 more
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Mechanisms of aneuploidy [PDF]
Current Opinion in Cell Biology, 2011 Accurate chromosome segregation during cell division is essential for genome integrity. Errors in chromosome segregation are irreversible and lead to a state of aneuploidy where the number of chromosomes in a cell or organism is not a multiple of the haploid number of chromosomes.
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Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability
Nature Communications, 2017 Recent findings suggest that forces acting on the cell nucleus can cause DNA damage, but the mechanisms are unclear. Here Takakiet al. report that actomyosin is a determinant of nuclear shape and that unrestrained contractility elicits nuclear envelope ...
Tohru Takaki +10 more
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Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes
Cell Discovery, 2023 Aneuploidy seriously compromises female fertility and increases incidence of birth defects. Rates of aneuploidy in human eggs from even young women are significantly higher than those in other mammals.
Jie Dong +9 more
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Aneuploidy in Cancer and Aging [PDF]
Annual Review of Genetics, 2016 Chromosomal instability (CIN), the persistent inability of a cell to faithfully segregate its genome, is a feature of many cancer cells. It stands to reason that CIN enables the acquisition of multiple cancer hallmarks; however, there is a growing body of evidence suggesting that CIN impairs cellular fitness and prevents neoplastic transformation ...
Naylor, R.M., Deursen, J.M.A. van
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Aneuploidy and confined chromosomal mosaicism in the developing human brain. [PDF]
PLoS ONE, 2007 BACKGROUND: Understanding the mechanisms underlying generation of neuronal variability and complexity remains the central challenge for neuroscience.
Yuri B Yurov +11 more
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How to Survive Aneuploidy [PDF]
Cell, 2010 Aneuploidy, or an abnormal number of chromosomes, adversely affects cell growth, but it is also linked with cancer and tumorigenesis. Now, Torres et al. (2010) help to resolve this paradox by demonstrating that aneuploid yeast cells can evolve mutations in the proteasome protein degradation pathway that alleviate imbalances in protein production and ...
Don W. Cleveland, Bulent Cetin
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mBio, 2017 Aneuploidy is usually deleterious in multicellular organisms but appears to be tolerated and potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major protozoan parasite, is emerging as a new model for aneuploidy, since in
F. Dumetz +17 more
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Molecular signatures of aneuploidy-driven adaptive evolution
Nature Communications, 2020 Aneuploidy (abnormal chromosome number) can enable rapid adaptation to stress conditions, but it also entails fitness costs from gene imbalance. Here, the authors experimentally evolve yeast while forcing maintenance of aneuploidy to identify the ...
Alaattin Kaya +8 more
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Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness
Nature Communications, 2022 Aneuploidy results in decreased cellular fitness in many species and model systems. However, aneuploidy is commonly found in cancer cells and often correlates with aggressive growth, suggesting that the impact of aneuploidy on cellular fitness is context
Federica Schiavoni +7 more
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