Results 21 to 30 of about 95,739 (341)
FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
Nature Communications, 2018 Evidence for mitotic decline in aged cells and for aneuploidy-driven progression into full senescence is limited. Here, the authors find that in aged cells, mitotic gene repression leads to increased chromosome mis-segregation and aneuploidy that ...
Joana Catarina Macedo +9 more
doaj +1 more source
Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes
Cell Discovery, 2023 Aneuploidy seriously compromises female fertility and increases incidence of birth defects. Rates of aneuploidy in human eggs from even young women are significantly higher than those in other mammals.
Jie Dong +9 more
doaj +1 more source
Aneuploidy in Cancer and Aging [PDF]
Annual Review of Genetics, 2016 Chromosomal instability (CIN), the persistent inability of a cell to faithfully segregate its genome, is a feature of many cancer cells. It stands to reason that CIN enables the acquisition of multiple cancer hallmarks; however, there is a growing body of evidence suggesting that CIN impairs cellular fitness and prevents neoplastic transformation ...
Naylor, R.M., Deursen, J.M.A. van
openaire +4 more sources
DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes [PDF]
, 2012 There is some interest in how mammalian oocytes respond to different types of DNA damage because of the increasing expectation of fertility preservation in women undergoing chemotherapy.
Julie A. Merriman +4 more
core +10 more sources
Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability
Nature Communications, 2017 Recent findings suggest that forces acting on the cell nucleus can cause DNA damage, but the mechanisms are unclear. Here Takakiet al. report that actomyosin is a determinant of nuclear shape and that unrestrained contractility elicits nuclear envelope ...
Tohru Takaki +10 more
doaj +1 more source
Aneuploidy facilitates dysplastic and tumorigenic phenotypes in the Drosophila gut
Biology Open, 2021 Aneuploidy has been strongly linked to cancer development, and published evidence has suggested that aneuploidy can have an oncogenic or a tumor suppressor role depending on the tissue context.
Rita Brás +3 more
doaj +1 more source
How to Survive Aneuploidy [PDF]
Cell, 2010 Aneuploidy, or an abnormal number of chromosomes, adversely affects cell growth, but it is also linked with cancer and tumorigenesis. Now, Torres et al. (2010) help to resolve this paradox by demonstrating that aneuploid yeast cells can evolve mutations in the proteasome protein degradation pathway that alleviate imbalances in protein production and ...
Don W. Cleveland, Bulent Cetin
openaire +3 more sources
mBio, 2017 Aneuploidy is usually deleterious in multicellular organisms but appears to be tolerated and potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major protozoan parasite, is emerging as a new model for aneuploidy, since in
F. Dumetz +17 more
doaj +1 more source
Selfish centromeres and the wastefulness of human reproduction.
PLoS Biology, 2022 Many human embryos die in utero owing to an excess or deficit of chromosomes, a phenomenon known as aneuploidy; this is largely a consequence of nondisjunction during maternal meiosis I.
Laurence D Hurst
doaj +1 more source
On the origin of trisomy 21 Down syndrome [PDF]
, 2008 Background: Down syndrome, characterized by an extra chromosome 21 is the most common genetic cause for congenital malformations and learning disability.
Hultén, Maj A. +6 more
core +2 more sources