Results 31 to 40 of about 50,865 (308)
Fertility & Reproduction, 2023 Background and Aims: Embryo aneuploidy is caused by many factors, including patient age, sperm quality and sperm selection method. There are several methods for selecting sperm, ICSI (intracytoplasmic sperm injection) and IMSI (intracytoplasmic ...
Reza Raharjo +3 more
doaj +1 more source
Estimate of genetic variants using CNV‐Seq for fetuses with oligohydramnios or polyhydramnios
Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023 The overall detection rate of clinically significant findings was 8%, with 5.0% in the isolated group and 11.0% in non‐isolated group. Non‐isolated group especially oligohydramnios subgroup is inclined to obtained more pathogenicity genetic anomalies and to terminate their pregnancy outcome.
Panlai Shi +5 more
wiley +1 more source
PLoS Biology, 2019 Studying aneuploidy during organism development has strong limitations because chronic mitotic perturbations used to generate aneuploidy usually result in lethality.
Mihailo Mirkovic +4 more
doaj +1 more source
Selfish centromeres and the wastefulness of human reproduction.
PLoS Biology, 2022 Many human embryos die in utero owing to an excess or deficit of chromosomes, a phenomenon known as aneuploidy; this is largely a consequence of nondisjunction during maternal meiosis I.
Laurence D Hurst
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Hidden Markov models for the assessment of chromosomal alterations using high-throughput SNP arrays [PDF]
Annals of Applied Statistics 2008, Vol. 2, No. 2, 687-713, 2008 Chromosomal DNA is characterized by variation between individuals at the level of entire chromosomes (e.g., aneuploidy in which the chromosome copy number is altered), segmental changes (including insertions, deletions, inversions, and translocations), and changes to small genomic regions (including single nucleotide polymorphisms).
arxiv +1 more source
Molecular Reproduction and Development, Volume 89, Issue 12, Page 597-607, December 2022., 2022 Abstract With the advancement of single‐cell separation techniques and high‐throughput sequencing platforms, single‐cell RNA‐sequencing (scRNA‐seq) has emerged as a vital technology for understanding tissue and organ systems at cellular resolution. Through transcriptional analysis, it is possible to characterize unique or rare cell types, interpret ...
Jordan H. Machlin, Ariella Shikanov
wiley +1 more source
Chromosomal Instability, Aneuploidy, and Gene Mutations in Human Sporadic Colorectal Adenomas
Cellular Oncology, 2004 Whether in vivo specific gene mutations lead to chromosomal instability (CIN) and aneuploidy or viceversa is so far not proven. We hypothesized that aneuploidy among human sporadic colorectal adenomas and KRAS2 and APC mutations were not independent ...
Walter Giaretti +3 more
doaj +1 more source
Consequences of Chromosome Loss: Why Do Cells Need Each Chromosome Twice?
Cells, 2022 Aneuploidy is a cellular state with an unbalanced chromosome number that deviates from the usual euploid status. During evolution, elaborate cellular mechanisms have evolved to maintain the correct chromosome content over generations.
Narendra Kumar Chunduri +2 more
doaj +1 more source
Meta-Analytic Operation of Threshold-independent Filtering (MOTiF) Reveals Sub-threshold Genomic Robustness in Trisomy [PDF]
arXiv, 2023 Trisomy, a form of aneuploidy wherein the cell possesses an additional copy of a specific chromosome, exhibits a high correlation with cancer. Studies from across different hosts, cell-lines, and labs into the cellular effects induced by aneuploidy have conflicted, ranging from small, chaotic global changes to large instances of either overexpression ...
arxiv
Accurate chromosome segregation by probabilistic self-organization [PDF]
BMC Biology 2015 13:65, 2014 Background: For faithful chromosome segregation during cell division, correct attachments must be established between sister chromosomes and microtubules from opposite spindle poles through kinetochores (chromosome bi-orientation). Incorrect attachments of kinetochore microtubules (kMTs) lead to chromosome mis-segregation and aneuploidy, which is often
arxiv +1 more source