Results 101 to 110 of about 101,532 (231)

Progress in Synthesis and Pharmacology of Telmisartan

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Telmisartan is a benzimidazole derivative and a well‐known drug to treat hypertension. This review provides synthesis and understanding of telmisartan as an antihypertensive drug through two mechanisms of actions: RAAS inhibitor and PPARγ receptor. Effective repurposing of this drug for various diseases like chronic kidney illness, diabetes, fatty ...
Megha, Richa Srivastava, Ram Singh
wiley   +1 more source

Fitting ideals and module structure [PDF]

, 2002
Let R be a commutative ring with a 1. Original work by H. Fitting showed how we can associate to each finitely generated E-module a unique sequence of R-ideals, which are known as Fitting Ideals. The aim of this thesis is to undertake an investigation of
Grime, Peter John
core  

Long‐Term Renal Function and Clinical Outcomes of Sacubitril/Valsartan in HFrEF and Stage 3–4 Chronic Kidney Disease: A 24‐Month Single‐Centre Cohort

Clinical Cardiology, Volume 49, Issue 9, September 2026.
In this 24‐month, single‐centre cohort of 360 patients with HFrEF and stage 3–4 chronic kidney disease, sacubitril/valsartan was well tolerated, with stable renal function, improved symptoms, and low rates of renal events and mortality. These descriptive findings are hypothesis‐generating and warrant confirmation in controlled studies.
Fatih Akkaya, Onur Osman Şeker, Ercan Türkmen, Seçkin Dereli   +3 more
wiley   +1 more source

CRISPR‐Cas9 and precision editing technologies linking functional genomics to clinical translation in genetic diseases

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CRISPR‐Cas9 and precision editing technologies enable a variant‐mechanism‐driven framework for genetic disease research and therapeutic development. Pathogenic variants are first interpreted according to mutation type, coding or regulatory consequence, tissue context, and disease mechanism.
Zijing Wen, Jianming Su
wiley   +1 more source

Role of Non‐Thermal Processing Technologies in Modulating Protein Allergenicity in Legumes

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Non‐thermal processing technologies (NTTs) reduce legumes' allergenicity while preserving quality and nutrients retention (PEF, pulsed electric field; CP, cold plasma; HPP, high pressure processing; US, ultrasound; IR, infrared). ABSTRACT The global shift toward plant‐based diets has increased legume consumption due to health and environmental benefits.
Viateur Ngabonzima, Flora G. C. Ekezie, Alberta N. A. Aryee, John O. Onuh   +3 more
wiley   +1 more source

Diagnostyka wrodzonego obrzęku naczynioruchowego [PDF]

, 2018
Hereditary angioedema (HAE) is a rare disorder characterized by acute episodes of edema formation in the subcutis and/or the submucosa. The clinical picture of the disease resembles that of histamine-mediated angioedema, nevertheless bradykinin release ...
Cervenak, László, Kőhalmi, Kinga Viktória, Farkas, Henriette   +2 more
core  

Genome Editing for Glycogen Storage Diseases

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Gene therapy has been developed for several glycogen storage diseases and has advanced into clinical trials. However, the limitations of these gene therapies with regard to stability following treatment early in life have led to the development of genome editing.
Troy von Beck, Raymond Wang, Dwight Koeberl   +2 more
wiley   +1 more source

Mutations predisposing to hereditary nonpolyposis colorectal cancer: database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer.

, 1997
BACKGROUND & AIMS: Germline mutations in four DNA mismatch repair genes are known to cause susceptibility to hereditary nonpolyposis colorectal cancer (HNPCC).
Peltomäki P, PONZ DE LEON, Maurizio, The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer, Vasen HF   +3 more
core  

Dermatologic Best Practices for Manicures and Nail Care: A Systematic Review

JEADV Clinical Practice, Volume 5, Issue 3, Page 821-828, September 2026.
This systematic review shows emerging evidence that nail cosmetic practices pose significant dermatologic consequences, particularly among individuals with regular nail salon use. Emerging concerns include infectious complications, an expanding spectrum of acrylate‐related contact allergens, structural disruption and loss of normal nail unit anatomy ...
Nivetha Aravind, Olivia Burke, Brian W. Morrison   +2 more
wiley   +1 more source

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang, Xin Jiang, Xiangrong Song   +11 more
wiley   +1 more source