Results 21 to 30 of about 23,719 (217)

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Angiotensin–Neprilysin Inhibition in Acute Decompensated Heart Failure

New England Journal of Medicine, 2019
BACKGROUND Acute decompensated heart failure accounts for more than 1 million hospitalizations in the United States annually. Whether the initiation of sacubitril–valsartan therapy is safe and effective among patients who are hospitalized for acute ...
E. Velazquez, D. Morrow, A. DeVore, Carol I. Duffy, A. Ambrosy, K. Mccague, Ricardo A. Rocha, E. Braunwald   +7 more
semanticscholar   +1 more source

The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria

Allergy. European Journal of Allergy and Clinical Immunology, 2018
This evidence‐ and consensus‐based guideline was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. The conference was held on 1 December 2016.
T. Zuberbier, W. Aberer, R. Asero, A. Latiff, D. Baker, B. Ballmer-Weber, J. Bernstein, C. Bindslev‐Jensen, Z. Brzoza, R. Bedrikow, G. W. Canonica, M. Church, T. Craig, I. Danilycheva, C. Dressler, L. Ensina, A. Giménez-Arnau, K. Godse, M. Gonçalo, C. Grattan, J. Hébert, M. Hide, A. Kaplan, A. Kapp, C. Katelaris, Emek Kocatürk, K. Kulthanan, D. Larenas-Linnemann, T. Leslie, M. Magerl, P. Mathelier-Fusade, R. Meshkova, M. Metz, A. Nast, E. Nettis, H. Oude-Elberink, S. Rosumeck, S. Saini, M. Sánchez-Borges, P. Schmid‐Grendelmeier, P. Staubach, G. Sussman, E. Toubi, G. A. Vena, C. Vestergaard, B. Wedi, R. Werner, Z. Zhao, M. Maurer   +48 more
semanticscholar   +1 more source

Bradykinin Metabolism and Drug-Induced Angioedema

International Journal of Molecular Sciences, 2023
Bradykinin (BK) metabolism and its receptors play a central role in drug-induced angioedema (AE) without urticaria through increased vascular permeability. Many cardiovascular and diabetic drugs may cause BK-mediated AE.
S. Smolińska, D. Antolín-Amérigo, Florin-Dan Popescu   +2 more
semanticscholar   +1 more source

Prevalence of autoantibodies in a group of hereditary angioedema patients Prevalência de autoanticorpos em uma população com angioedema hereditário

Anais Brasileiros de Dermatologia, 2012
Hereditary Angioedema is a dominantly inherited disease. Routine screening of autoantibodies (AAB) is not recommended for individuals with Hereditary Angioedema; however, prevalence of these antibodies in Hereditary Angioedema patients is not well ...
Sergio Duarte Dortas Junior, Solange Oliveira Rodrigues Valle, Soloni Afra Pires Levy, Rosangela P. Tortora, Augusto Tiaqui Abe, Gisele Viana Pires, José Angelo de Souza Papi, Alfeu Tavares França   +7 more
doaj   +1 more source

Angiotensin-neprilysin inhibition versus enalapril in heart failure.

New England Journal of Medicine, 2014
BACKGROUND We compared the angiotensin receptor-neprilysin inhibitor LCZ696 with enalapril in patients who had heart failure with a reduced ejection fraction. In previous studies, enalapril improved survival in such patients.
J. McMurray, M. Packer, Akshay S. Desai, J. Gong, M. Lefkowitz, A. Rizkala, J. Rouleau, V. Shi, S. Solomon, K. Swedberg, M. Zile   +10 more
semanticscholar   +1 more source

Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

eLife, 2020
COVID-19 patients can present with pulmonary edema early in disease. We propose that this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) and B2R on endothelial cells in the lungs.
F. L. van de Veerdonk, M. Netea, M. van Deuren, J. V. D. van der Meer, Q. de Mast, R. Brüggemann, H. van der Hoeven   +6 more
semanticscholar   +1 more source

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Effect of cow's milk protein allergy during infancy on eating behavior at 4 years of age: A cohort study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives This study aimed to investigate the eating behaviors of preschool children who had been exposed to a restricted diet due to an oral food challenge‐confirmed diagnosis of cow's milk protein allergy (CMPA) during early infancy. Methods This prospective cohort study compared the eating behaviors of Brazilian children previously ...
Anne Jardim‐Botelho, Marcela Barros Barbosa de Oliveira, Jackeline Motta‐Franco, Tatiane Graça Martins, Sarah Cristina Fontes Vieira, Ikaro Daniel de Carvalho Barreto, Aline Vieira Bezerra, Ricardo Queiroz Gurgel   +7 more
wiley   +1 more source

Olive‐derived bioactive combinations: synergistic angiotensin‐I‐converting enzyme (ACE) inhibition and distinct mechanisms of triterpenic acids and phenolics

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Cardiovascular diseases, largely driven by hypertension, remain the leading cause of mortality worldwide. Angiotensin‐I‐converting enzyme (ACE) inhibition is a well‐established therapeutic approach; however, synthetic inhibitors are frequently associated with adverse effects.
Fátima Rubio‐Senent, Alejandra Bermúdez‐Oria, África Fernández‐Prior, Antonio Lama‐Muñoz, Guillermo Rodríguez‐Gutiérrez, Juan Fernández‐Bolaños   +5 more
wiley   +1 more source