Results 41 to 50 of about 594 (209)

Cellular Responses to Tartrazine and Sulfanilic Acid Exposure in BEAS‐2B Cells: Viability, Apoptosis, and DNA Damage

Journal of Applied Toxicology, EarlyView.
ABSTRACT Tartrazine is a synthetic azo dye widely used in food, pharmaceutical, and cosmetic products, resulting in extensive human exposure, while its toxicity and that of its primary metabolite, sulfanilic acid, remain controversial. Considering the reported association of tartrazine with hypersensitivity and allergic‐like reactions, human bronchial ...
Merve Baysal, Abdullah Burak Karaduman, Büşra Korkut Çelikateş, Merve Güven, Özlem Atlı‐Eklioğlu, Sinem Ilgın   +5 more
wiley   +1 more source

Berotralstat for long-term prophylaxis of hereditary angioedema in Japan: Parts 2 and 3 of the randomized APeX-J Phase III trial

World Allergy Organization Journal
Background: Berotralstat is a once-daily oral inhibitor of plasma kallikrein for the prophylaxis of hereditary angioedema (HAE) in patients ≥12 years. APeX-J aimed to evaluate the efficacy and safety of berotralstat in Japan.
Daisuke Honda, MD, PhD, Michihiro Hide, MD, PhD, Tomoo Fukuda, MD, PhD, Keisuke Koga, MD, PhD, Eishin Morita, MD, PhD, Shinichi Moriwaki, MD, Yoshihiro Sasaki, MD, PhD, Yusuke Suzuki, MD, PhD, Phil Collis, PhD, Douglas T. Johnston, DO, Dianne Tomita, MPH, Bhavisha Desai, PharmD, Isao Ohsawa, MD, PhD   +12 more
doaj   +1 more source

Ocular facial myositis and sialadenitis presenting with new onset ulcerative colitis

JPGN Reports, EarlyView.
Abstract Extra‐intestinal manifestations of inflammatory bowel disease (IBD) can involve most organ systems, although the immunologic underpinnings are not well understood. Most patients who present with an extra‐intestinal manifestation have a single site of extra‐intestinal involvement; however, a small cohort presents with multiple different sites ...
Nicole Du, Nicole Mendez, Anil Darbari
wiley   +1 more source

Dermatologic Best Practices for Manicures and Nail Care: A Systematic Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Manicure and pedicure procedures are widely viewed as benign cosmetic practices, yet emerging evidence links them to various dermatologic complications, including dermatitis, infection, photodamage and, in rare cases, cutaneous malignancy.
Nivetha Aravind, Olivia Burke, Brian W. Morrison   +2 more
wiley   +1 more source

Long‐Term Outcomes of Patients Undergoing Cricothyrotomy at a Tertiary Care Level One Trauma Center

The Laryngoscope, EarlyView.
This retrospective study of 48 patients undergoing emergent cricothyrotomy (2014–2025) evaluated short‐ and long‐term outcomes and complications. Common complications included dysphagia, pneumonia, and dysphonia, with delayed conversion to tracheostomy associated with increased pneumonia risk; long‐term issues included persistent dysphagia, subglottic ...
Shivani Raizada, Yekaterina Shapiro, Reshma Modi, Bailey Balouch, Kathy Zhang, John Chovanes, Donald Solomon   +6 more
wiley   +1 more source

Global, Regional, and National Burden of Urticaria (1990–2021) and Forecasts to 2036: Systematic Analysis of the Global Burden of Disease Study 2021

Medicine Advances, EarlyView.
In our study, we conducted a comprehensive and systematic analysis of the latest global disease burden of urticaria from an epidemiological perspective, employing multiple analytical approaches. Specifically, we examined the burden of urticaria in terms of incidence, prevalence, and disability‐adjusted life years, stratified by sex, age, and region, as
Xingke Zhu, Qing Lv
wiley   +1 more source

Reply to “A Case Report about the Management of Hereditary Angioedema with Normal Complement Levels during Pregnancy”

Acta Médica Portuguesa
N/A.
Ana Luísa Moura, Ângela Gaspar, Luís Miguel Borrego   +2 more
doaj   +1 more source

Real‐World Safety and Effectiveness of Glatiramer Acetate in Patients With Multiple Sclerosis: Final Results of Post‐Marketing Surveillance in Japan

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Background Glatiramer acetate is an injectable disease‐modifying therapy indicated for multiple sclerosis (MS). Aim To evaluate the real‐world safety and effectiveness of glatiramer acetate for MS in Japan. Methods A prospective, multicenter, observational, all‐case post‐marketing survey was conducted in Japan between November 2015 and March ...
Masaaki Niino, Eriko Hayashi, Mai Itani, Jun‐ichi Kira   +3 more
wiley   +1 more source

Icatibant, an inhibitor of bradykinin receptor 2, for hereditary angioedema attacks: prospective experimental single-cohort study

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Hereditary angioedema (HAE) with C1 inhibitor deficiency manifests as recurrent episodes of edema involving the skin, upper respiratory tract and gastrointestinal tract. It can be lethal due to asphyxia.
Regis Albuquerque Campos, Solange Oliveira Rodrigues Valle, Alfeu Tavares França, Elisabete Cordeiro, Faradiba Sarquis Serpa, Yara Ferreira Mello, Teresinha Malheiros, Eliana Toledo, Elie Mansour, Gustavo Fusaro, Anete Sevciovic Grumach   +10 more
doaj   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source