Results 51 to 60 of about 9,793 (303)

Berotralstat for long-term prophylaxis of hereditary angioedema in Japan: Parts 2 and 3 of the randomized APeX-J Phase III trial

World Allergy Organization Journal
Background: Berotralstat is a once-daily oral inhibitor of plasma kallikrein for the prophylaxis of hereditary angioedema (HAE) in patients ≥12 years. APeX-J aimed to evaluate the efficacy and safety of berotralstat in Japan.
Daisuke Honda, MD, PhD, Michihiro Hide, MD, PhD, Tomoo Fukuda, MD, PhD, Keisuke Koga, MD, PhD, Eishin Morita, MD, PhD, Shinichi Moriwaki, MD, Yoshihiro Sasaki, MD, PhD, Yusuke Suzuki, MD, PhD, Phil Collis, PhD, Douglas T. Johnston, DO, Dianne Tomita, MPH, Bhavisha Desai, PharmD, Isao Ohsawa, MD, PhD   +12 more
doaj   +1 more source

When protein losing enteropathy persists: A case series of viral and lymphatic‐associated etiologies

JPGN Reports, EarlyView.
Abstract Protein‐losing enteropathy (PLE) is a rare condition that is characterized by loss of plasma protein in the intestines leading to hypoproteinemia with subsequent peripheral edema and possibly anasarca. The pathophysiology of PLE varies depending on the etiology and involves either intestinal mucosal injury or lymphatic system alterations ...
Natalie Jennings, Antonia C. Rovira, Pamela Castillo Rocha, Janelle Torres, Claudia M. Salgado, Miguel Reyes‐Múgica, Richard N. Arboleda, Fatima S. Hussain   +7 more
wiley   +1 more source

Ocular facial myositis and sialadenitis presenting with new onset ulcerative colitis

JPGN Reports, EarlyView.
Abstract Extra‐intestinal manifestations of inflammatory bowel disease (IBD) can involve most organ systems, although the immunologic underpinnings are not well understood. Most patients who present with an extra‐intestinal manifestation have a single site of extra‐intestinal involvement; however, a small cohort presents with multiple different sites ...
Nicole Du, Nicole Mendez, Anil Darbari
wiley   +1 more source

Angioedema: ACE-Inhibitors Adverse Reaction [PDF]

, 2017
This is a poster presentation about angioedema caused by Angiotensin-converting enzyme (ACEI or ACE Inhibitors). Angiotensin-converting enzyme inhibitor (ACEI) medications are one of the leading causes of angioedema in the United States, also known as ...
VanDyne, Jesse
core   +1 more source

ANGIOEDEMA HEREDITÁRIO: UMA ATUALIZAÇÃO. [PDF]

, 2015
Objective: Hereditary angioedema is a genetic disease with autosomal dominance inheritance characterized by quantitative and qualitative deficiency of C1 inhibitor, resulting in edema of multiples organs.
Chong Neto, Herberto José, Machado, Ana Flávia, Riedi, Carlos Antônio, Rosário, Nelson Augusto, Thomaz, José Eduardo   +4 more
core   +2 more sources

Long‐Term Outcomes of Patients Undergoing Cricothyrotomy at a Tertiary Care Level One Trauma Center

The Laryngoscope, EarlyView.
This retrospective study of 48 patients undergoing emergent cricothyrotomy (2014–2025) evaluated short‐ and long‐term outcomes and complications. Common complications included dysphagia, pneumonia, and dysphonia, with delayed conversion to tracheostomy associated with increased pneumonia risk; long‐term issues included persistent dysphagia, subglottic ...
Shivani Raizada, Yekaterina Shapiro, Reshma Modi, Bailey Balouch, Kathy Zhang, John Chovanes, Donald Solomon   +6 more
wiley   +1 more source

MANIFESTAÇÕES CLÍNICAS OU LESÕES ASSOCIADAS A EFEITOS ADVERSOS A MEDICAMENTOS EM CAVIDADE ORAL [PDF]

, 2017
A Organização Mundial de Saúde define uma reação adversa a medicamento (RAM) como uma resposta nociva a uma droga, não intencional, que ocorre com doses normalmente utilizadas no homem para a profilaxia, terapia ou diagnóstico de uma doença, ou ainda ...
Mercês, Eduardo Costa
core   +2 more sources

Gene List Selection Matters: Missed Diagnoses in Prenatal Exome Sequencing—PanelApp R21 and HPO‐Driven Versus OMIM‐Based Gene Lists

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To evaluate whether the causative variants found upon clinical exome sequencing in fetuses affected with selected structural anomalies would also be detected if PanelApp‐R21 or Human Phenotype Ontology (HPO)‐driven gene selection terms were applied instead.
Victoria Ardiles‐Ruesjas, Laia Rodriguez‐Revenga, Montse Pauta, Alfons Nadal, Gemma Arca, Laura Gort, Stiven Ernesto Sinisterra‐Díaz, Antoni Borrell   +7 more
wiley   +1 more source

Cross Sectional Study of Prenatal Diagnosis Uptake Among Individuals With Genetic Conditions

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Prenatal diagnostic genetic testing allows for early identification of significant fetal conditions and enables informed decision‐making regarding management options. The aim of this study was to assess prenatal testing practice among individuals with genetic conditions.
Ebunoluwa Ojo, Roni Zemet, Allyson Nevins, Katherine Abraham, April D. Adams   +4 more
wiley   +1 more source

Hereditary angioedema: how to approach it at the emergency department?

Einstein (São Paulo)
Angioedema attacks are common causes of emergency care, and due to the potential for severity, it is important that professionals who work in these services know their causes and management.
Faradiba Sarquis Serpa, Eli Mansour, Marcelo Vivolo Aun, Pedro Giavina-Bianchi, Herberto José Chong Neto, Luisa Karla Arruda, Regis Albuquerque Campos, Antônio Abílio Motta, Eliana Toledo, Anete Sevciovic Grumach, Solange Oliveira Rodrigues Valle   +10 more
doaj   +2 more sources