Results 251 to 260 of about 481,605 (317)
This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang+13 more
wiley +1 more source
A novel oridonin analogue, CYD0682, suppresses breast cancer growth, angiogenesis, and metastasis by inhibiting the ANGPTL4/MAPK signaling axis. [PDF]
Mai X+15 more
europepmc +1 more source
Piezoelectric Biomaterials for Bone Regeneration: Roadmap from Dipole to Osteogenesis
Piezoelectric biomaterials convert mechanical forces into electrical signals, offering novel strategies to restore and modulate bone microenvironments for tissue engineering. This review examines molecular dipole origins, spatial arrangements, and pseudo‐piezoelectric mechanisms and highlights dipole‐engineering techniques for osteogenesis regulation ...
Xiyao Ni+7 more
wiley +1 more source
A combined optical coherence tomography angiography and fluorescence imaging approach assesses tumor angiogenesis and drug effects in a novel zebrafish cancer model. By analyzing 3D vasculature data, the two imaging methods complement each other to quantify blood flow, vessel structure, and drug efficacy.
Marco Andreana+10 more
wiley +1 more source
Endostatin-based anti-angiogenic therapy and immune modulation: mechanisms and synergistic potential in cancer treatment. [PDF]
Sun J+5 more
europepmc +1 more source
Activation of HTR2B suppresses osteosarcoma progression through the STAT1‐NLRP3 inflammasome pathway and promotes OASL1+ Macrophage production to enhance anti‐tumor immunity. Abstract Osteosarcoma is a primary malignant bone tumor originating from mesenchymal tissue, and associated with poor prognosis.
Zhen Huang+7 more
wiley +1 more source
Mechanism of Curcumol Targeting the OTUB1/TGFBI Ubiquitination Pathway in the Inhibition of Angiogenesis in Colon Cancer. [PDF]
Zhu Y+7 more
europepmc +1 more source
Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity
Modulation of the innate immune response at the implant site can significantly influence adaptive immunity. A mannose‐functionalized collagen patch, termed the Local Immunotuning Patch (LIP), has been designed to engage mannose receptors on antigen‐presenting cells while exhibiting antibacterial properties. LIP orchestrates complex immune pathways that
Francesca Taraballi+10 more
wiley +1 more source
Exosomes derived from M2 macrophage promote HUVECs proliferation, migration and tube formation in vitro. [PDF]
Xue Y+7 more
europepmc +1 more source
Pischiutta F and coworkers identify prostaglandins and kynurenine as key mediators of the mesenchymal stromal cells‐derived secretome's neuroprotective effects. A synthetic cocktail composed of these factors promotes long‐term functional recovery, reduces brain structural damage, and modulates neuroinflammation after traumatic brain injury, supporting ...
Francesca Pischiutta+24 more
wiley +1 more source