Results 21 to 30 of about 991,798 (411)

Isolation and separation of murine tumor-associated macrophages (TAMs) subpopulations from orthotopic 4T1 breast tumors

STAR Protocols, 2021
Summary: Tumor-associated macrophages (TAMs) are highly heterogenous regarding their intratumoral localization, surface marker expression, and molecular properties.
Pawel Bieniasz-Krzywiec, Rosa Martín-Pérez, Carla Riera-Domingo, Massimiliano Mazzone   +3 more
doaj   +1 more source

Publisher Correction: High mitogenic stimulation arrests angiogenesis

Nature Communications, 2019
The original version of this Article contained errors in Fig. 8. In panel a, the labels ‘VEGF’, ‘Notch’, ‘p21’, and ‘P-ERK’ were inadvertently omitted. This has been corrected in the PDF and HTML versions of the Article.
Samuel Pontes-Quero, Macarena Fernández-Chacón, Wen Luo, Federica Francesca Lunella, Verónica Casquero-Garcia, Irene Garcia-Gonzalez, Ana Hermoso, Susana F. Rocha, Mayank Bansal, Rui Benedito   +9 more
doaj   +1 more source

High mitogenic stimulation arrests angiogenesis

Nature Communications, 2019
High mitogenic stimuli have been suggested to promote endothelial cell proliferation and sprouting during angiogenesis. Here Pontes-Quero et al., by interfering with levels of VEGF and Notch signalling in single endothelial cells in vivo, find that high ...
Samuel Pontes-Quero, Macarena Fernández-Chacón, Wen Luo, Federica Francesca Lunella, Verónica Casquero-Garcia, Irene Garcia-Gonzalez, Ana Hermoso, Susana F. Rocha, Mayank Bansal, Rui Benedito   +9 more
doaj   +1 more source

How Endothelial Cells Adapt Their Metabolism to Form Vessels in Tumors

Frontiers in Immunology, 2017
Endothelial cells (ECs) line blood vessels, i.e., vital conduits for oxygen and nutrient delivery to distant tissues. While mostly present as quiescent “phalanx” cells throughout adult life, ECs can rapidly switch to a migratory “tip” cell and a ...
Annalisa Zecchin, Annalisa Zecchin, Joanna Kalucka, Joanna Kalucka, Charlotte Dubois, Charlotte Dubois, Peter Carmeliet, Peter Carmeliet   +7 more
doaj   +1 more source

Angiogenesis and schistosomiasis [PDF]

Memórias do Instituto Oswaldo Cruz, 2010
Angiogenesis has been recognised as a precursor of fibrosis in several pathologic conditions. Its participation has been demonstrated in schistosomiasis, both during periovular granuloma formation and in the genesis of schistosomal periportal fibrosis. Paradoxically, proliferation of new blood vessels, accompanied by production of vascular-endothelial ...
Andrade, Zilton A., Santana, Thaynã Souto   +1 more
openaire   +5 more sources

Angiotensin II and VEGF are Involved in Angiogenesis Induced by Short-Term Exercise Training [PDF]

, 2001
Results from our laboratory have suggested a pathway involving angiotensin II type 1 (AT1) receptors and vascular endothelial growth factor (VEGF) in angiogenesis induced by electrical stimulation.
Amaral, Sandra L., Greene, Andrew S., Papanek, Paula   +2 more
core   +2 more sources

Glycolytic regulation of cell rearrangement in angiogenesis

Nature Communications, 2016
Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing ...
Bert Cruys, Brian W. Wong, Anna Kuchnio, Dries Verdegem, Anna Rita Cantelmo, Lena-Christin Conradi, Saar Vandekeere, Ann Bouché, Ivo Cornelissen, Stefan Vinckier, Roeland M. H. Merks, Elisabetta Dejana, Holger Gerhardt, Mieke Dewerchin, Katie Bentley, Peter Carmeliet   +15 more
doaj   +1 more source

Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. [PDF]

, 2014
To enable new blood vessel growth, endothelial cells (ECs) express neuropilin 1 (NRP1), and NRP1 associates with the receptor tyrosine kinase VEGFR2 after binding the vascular endothelial growth factor A (VEGF) to enhance arteriogenesis.
Alessandro Fantin, Anastasia Lampropoulou, Anissa Chikh, Anselmi, Ballmer-Hofer, Baruzzi, Birukova, Buchdunger, Campochiaro, Carmeliet, Casanovas, Chen, Chen, Chislock, Cho, Choi, Christiana Ruhrberg, Clark, Claudio Raimondi, Colicelli, Connor, Cui, Cujec, Dejana, Druker, Fantin, Fantin, Fantin, Fantin, Foxton, Fukasawa, Gerhardt, Gerhardt, Herzog, Kawamura, Kawasaki, Kim, Kitsukawa, Koch, Lanahan, Lanahan, Laura Denti, Lewis, Lewis, Mamluk, Murga, Nishijima, Pan, Pan, Parsons, Pasapera, Phng, Raimondi, Ren, Robinson, Roig, Rosenfeld, Ruhrberg, Ruhrberg, Saint-Geniez, Salikhova, Shimizu, Shojaei, Smith, Soker, Sottile, Stenzel, Tvorogov, Uemura, Valdembri, Wang, Welti, Yaqoob, Zaidel-Bar, Zhuang   +74 more
core   +4 more sources

Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy. [PDF]

, 2016
BackgroundEstrogen pretreatment has been shown to attenuate the development of heart hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF).
Bopassa, Jean C, Centala, Alexander, Eghbali, Mansoureh, Iorga, Andrea, Li, Jingyuan, Nadadur, Rangarajan D, Ren, Shuxun, Saito, Tomoaki, Sharma, Salil, Stefani, Enrico, Toro, Ligia, Umar, Soban, Wang, Yibin   +12 more
core   +1 more source

iSuRe-Cre is a genetic tool to reliably induce and report Cre-dependent genetic modifications

Nature Communications, 2019
The Cre-Lox system allows high spatiotemporal control of genetic modifications. Here the authors present iSuRe-Cre that significantly increases Cre activity in reporter expressing cells, which ultimately increases the efficiency and reliability of Cre ...
Macarena Fernández-Chacón, Verónica Casquero-García, Wen Luo, Federica Francesca Lunella, Susana Ferreira Rocha, Sergio Del Olmo-Cabrera, Rui Benedito   +6 more
doaj   +1 more source