Results 1 to 10 of about 3,183,533 (410)
Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors. [PDF]
PLoS ONE, 2013 Current inhibitors of angiogenesis comprise either therapeutic antibodies (e.g. bevacicumab binding to VEGF-A) or small molecular inhibitors of receptor tyrosin kinases like e.g. sunitinib, which inhibits PDGFR and VEGFR.
Fürst, Robert +8 more
core +12 more sources
Editorial: Angiogenesis and Angiogenesis Inhibitors in Oral Cancer. [PDF]
Front Oral Health, 2021 Non peer ...
Salem A, Hadler-Olsen E, Al-Samadi A.
europepmc +7 more sources
Cardiotoxic effects of angiogenesis inhibitors. [PDF]
Clin Sci (Lond), 2021 Abstract The development of new therapies for cancer has led to dramatic improvements in survivorship. Angiogenesis inhibitors represent one such advancement, revolutionising treatment for a wide range of malignancies. However, these drugs are associated with cardiovascular toxicities which can impact optimal cancer treatment in the ...
Dobbin SJH +4 more
europepmc +7 more sources
Endogenous inhibitors of angiogenesis [PDF]
Journal of Cell Science, 2001 In the course of embryonic development, during some normal physiological processes in the adult, such as the female reproductive cycle, and also in a variety of pathologies, including tumour growth, new blood vessels develop from the pre-existing vascular network through endothelial cell sprouting,
Ruhrberg, C
core +8 more sources
Angiogenesis Inhibitors in NSCLC. [PDF]
Int J Mol Sci, 2017 Angiogenesis is a complex biological process that plays a relevant role in sustaining the microenvironment, growth, and metastatic potential of several tumors, including non-small cell lung cancer (NSCLC). Bevacizumab was the first angiogenesis inhibitor approved for the treatment of patients with advanced NSCLC in combination with chemotherapy ...
Manzo A +10 more
europepmc +6 more sources
Thalidomide is an inhibitor of angiogenesis. [PDF]
Proceedings of the National Academy of Sciences, 1994 Thalidomide is a potent teratogen causing dysmelia (stunted limb growth) in humans. We have demonstrated that orally administered thalidomide is an inhibitor of angiogenesis induced by basic fibroblast growth factor in a rabbit cornea micropocket assay.
Michael S. Loughnan +3 more
openaire +4 more sources
Impaired tumor growth and angiogenesis in mice heterozygous for Vegfr2 (Flk1) [PDF]
, 2018 VEGF signaling through its tyrosine kinase receptor, VEGFR2 (FLK1), is critical for tumor angiogenesis. Previous studies have identified a critical gene dosage effect of VegfA in embryonic development and vessel homeostasis, neovascularization, and tumor
Choi, Kyunghee +4 more
core +3 more sources
Characterization of small molecules inhibiting the pro-angiogenic activity of the zinc finger transcription factor Vezf1 [PDF]
, 2018 Discovery of inhibitors for endothelial-related transcription factors can contribute to the development of anti-angiogenic therapies that treat various diseases, including cancer.
Gowher, Humaira +4 more
core +2 more sources
Status and future directions of anti-metastatic cancer nanomedicines for the inhibition of cathepsin L [PDF]
, 2020 Angiogenesis, tissue invasion and metastasis in the tumour microenvironment are all critical hallmarks of cancer. Upregulation of cathepsin L plays an important role in angiogenesis and metastasis through its ability to degrade the extracellular matrix ...
Pranjol, Md Zahidul I +3 more
core +2 more sources
A mathematical model of systemic inhibition of angiogenesis in metastatic development [PDF]
, 2013 We present a mathematical model describing the time development of a population of tumors subject to mutual angiogenic inhibitory signaling. Based on biophysical derivations, it describes organism-scale population dynamics under the influence of three ...
Benzekry, Sebastien +2 more
core +4 more sources