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Angiogenesis Inhibitors in Clinical Development; Where Are We Now and Where Are We Going?

British Journal of Cancer, 2004
Angiogenesis is crucial for tumour growth and the formation of metastases. Various classes of angiogenesis inhibitors that are each able to inhibit one of the various steps of this complex process can be distinguished.
F A L M Eskens
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Src Inhibitors and Angiogenesis

Current Pharmaceutical Design, 2007
Angiogenesis is a tightly regulated process that leads to the formation of new blood vessels in limited physiological conditions, and can also occur under pathological situations as retinopathies, arthritis, endometriosis and cancer. Enhanced angiogenesis is present in tumors that need new blood capillaries to grow, remove metabolic waste and transport
SCHENONE S, MANETTI, FABRIZIO, BOTTA, MAURIZIO   +2 more
openaire   +5 more sources

Inhibitors of Angiogenesis

2015
Angiogenesis plays a pivotal role in malignant, ischemic, inflammatory, infectious and immune disorders. The increasing molecular understanding of angiogenic processes fostered the development of strategies to induce or inhibit angiogenesis for therapeutic purposes.
H, Büning, U T, Hacker
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Protamine is an inhibitor of angiogenesis

Nature, 1982
Protamine is shown to be a specific inhibitor of angiogenesis. The compound inhibits the capillary proliferation observed in embryogenesis, inflammation, certain immune reactions and the growth of solid tumours.
S, Taylor, J, Folkman
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Endogenous Inhibitors of Angiogenesis

Cancer Research, 2005
Abstract Angiogenesis, the formation of new blood vessels, is required for many pathologic processes, including invasive tumor growth as well as physiologic organ/tissue maintenance. Angiogenesis during development and adulthood is likely regulated by a balance between endogenous proangiogenic and antiangiogenic factors. It is speculated
Pia, Nyberg, Liang, Xie, Raghu, Kalluri
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Metalloproteinases and their inhibitors in angiogenesis

Expert Reviews in Molecular Medicine, 2003
Angiogenesis, the formation of new blood vessels from the pre-existing vasculature, is an integral part of physiological processes such as embryonic development, the female reproductive cycle and wound healing. Angiogenesis is also central to a variety of pathologies including cancer, where it is recognised as being crucial for the growth of solid ...
Lafleur, M.A., Handsley, M.M., Edwards, D.R.   +2 more
openaire   +3 more sources

Update on angiogenesis inhibitors

Current Opinion in Oncology, 2005
A number of therapeutic agents have been developed which have anti-angiogenic potential. Here we present the most recent data from clinical trials with some of the promising inhibitors of angiogenesis.Agents that target the vascular endothelial growth factor signaling pathway are the furthest along in clinical development.
Anaadriana, Zakarija, Gerald, Soff
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Emoxypine as an inhibitor of angiogenesis

Bulletin of Experimental Biology and Medicine, 1992
The effect of emoxypin on angiogenesis in rabbit cornea in aseptic inflammation induced by intracorneal implantation of a piece of quartz and on the development of the vessels of the chick embryo yolk sac was studied. 1% emoxypin pipetted thrice a day for 10-14 days inhibited corneal neovascularization and reduced the formation of new blood vessels. We
A A, Sologub, S I, Akberova, G G, Ziangirova   +2 more
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Tumor Angiogenesis Inhibitors

Biochemistry (Moscow), 2003
Formation of the blood supply system is a critical step in malignant transformation of neoplasms which results in the penetration of tumor cells into neighboring tissues and metastatic growth. Significant progress in the elucidation of mechanisms underlying tumor angiogenesis and the discovery of a great diversity of biomolecules involved in its ...
S M, Kiselev, S V, Lutsenko, S E, Severin, E S, Severin   +3 more
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Maspin is an angiogenesis inhibitor

Nature Medicine, 2000
Maspin, a unique member of the serpin family, is a secreted protein encoded by a class II tumor suppressor gene whose downregulation is associated with the development of breast and prostate cancers. Overexpression of maspin in breast tumor cells limits their growth and metastases in vivo.
M, Zhang, O, Volpert, Y H, Shi, N, Bouck
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