Results 51 to 60 of about 3,183,533 (410)

Contact-inhibited chemotaxis in de novo and sprouting blood-vessel growth [PDF]

PLoS Computational Biology 2008, 4(9): e1000163, 2005
Blood vessels form either when dispersed endothelial cells (the cells lining the inner walls of fully-formed blood vessels) organize into a vessel network (vasculogenesis), or by sprouting or splitting of existing blood vessels (angiogenesis). Although they are closely related biologically, no current model explains both phenomena with a single ...
arxiv   +1 more source

Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis [PDF]

, 2016
This is the preprint version of our manuscript, corresponding to the article that has been 
published in final form at FOOD CHEMISTRY with DOI: 10.1016/j.foodchem.2016.10.111The health benefits of olive oil are attributed to their bioactive compounds ...
García-Vilas, Javier A., Medina, Miguel Ángel, Quesada, Ana R.   +2 more
core   +1 more source

Irsogladine is a potent inhibitor of angiogenesis [PDF]

FEBS Letters, 1993
We describe a novel inhibitor of angiogenesis, Irsogladine, an anti‐ulcer drug. Irsogladine inhibited plasminogen activator synthesis of, and tube formation by, human microvascular endothelial cells in type 1 collagen gel treated with an angiogenic growth factor, EGF.
Kazuki Okamura, Yasufumi Sato, Toshiie Sakata, Kimitoshi Kohno, Ryoji Hamanaka, Akira Kiue, Akio Morimoto, Michihiko Kuwano   +7 more
openaire   +3 more sources

Limited Tumor Tissue Drug Penetration Contributes to Primary Resistance against Angiogenesis Inhibitors

Theranostics, 2017
Resistance mechanisms against antiangiogenic drugs are unclear. Here, we correlated the antitumor and antivascular properties of five different antiangiogenic receptor tyrosine kinase inhibitors (RTKIs) (motesanib, pazopanib, sorafenib, sunitinib ...
Szilvia Torok, M. Rezeli, O. Kelemen, Á. Végvári, Kenichi Watanabe, Y. Sugihara, A. Tisza, Timea Marton, I. Kovács, J. Tóvári, V. Laszlo, T. Helbich, B. Hegedűs, T. Klikovits, M. Hoda, W. Klepetko, S. Paku, G. Marko‐Varga, B. Dome   +18 more
semanticscholar   +1 more source

New molecular mediators in tumor angiogenesis [PDF]

, 2007
Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Beecken, Wolf-Dietrich, Jonas, Dietger, Kramer, Wolfgang   +2 more
core   +1 more source

Acetylcholinesterase inhibitors attenuate angiogenesis [PDF]

Clinical Science, 2012
Donepezil {(RS)-2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one} is a reversible acetylcholinesterase inhibitor and used for treatment of patients with AD (Alzheimer's disease). Recent studies showed that treatment with donepezil reduced production of inflammatory cytokines in PBMCs (peripheral blood mononuclear cells).
Aya Kamiharaguchi, Kotaro Takeda, Ryohei Miyazaki, Toru Hashimoto, Jiro Ikeda, Toshihiro Ichiki, Eriko Narabayashi, Hirohide Matsuura, Kenji Sunagawa   +8 more
openaire   +3 more sources

Questionnaire survey of angiogenesis inhibitor-related oral complications based on a nation-wide study in Japan

Journal of Dental Sciences, 2021
Background/purpose: The prevalence of oral adverse events and dental treatments related complications during the molecular targeted drugs therapy remains unclear.
Shin-ichi Yamada, Hiroshi Kurita, Akira Tanaka, Masaru Miyata, Yoshinari Morimoto, Akira Yamaguchi, Souichi Yanamoto, Hiromasa Yoshikawa, Yutaka Imai   +8 more
doaj  

In silico identification of potential natural product inhibitors of human proteases key to SARS-CoV-2 infection [PDF]

Molecules 2020, 25(17), 3822, 2020
Presently, there are no approved drugs or vaccines to treat COVID-19 which has spread to over 200 countries and is responsible for over 3,65,000 deaths worldwide. Recent studies have shown that two human proteases, TMPRSS2 and cathepsin L, play a key role in host cell entry of SARS-CoV-2.
arxiv   +1 more source

A recommended practical approach to the management of target therapy and angiogenesis inhibitors cardiotoxicity: an opinion paper of the working group on drug cardiotoxicity and cardioprotection, Italian Society of Cardiology

Journal of Cardiovascular Medicine, 2016
The US National Cancer Institute estimates that cardiotoxicity (CTX) from target therapy refers mostly to four groups of drugs: epidermal growth factor receptor 2 inhibitors, angiogenic inhibitors, directed Abelson murine leukemia viral oncogene homolog ...
N. Maurea, P. Spallarossa, C. Cadeddu, R. Madonna, D. Mele, I. Monte, G. Novo, P. Pagliaro, A. Pepe, C. Tocchetti, C. Zito, G. Mercuro   +11 more
semanticscholar   +1 more source

Combined Treatment with MEK and mTOR Inhibitors is Effective in In Vitro and In Vivo Models of Hepatocellular Carcinoma. [PDF]

, 2019
Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer histotype, characterized by high biological aggressiveness and scarce treatment options.
Calvisi, Diego F, Che, Li, Chen, Xin, Evert, Matthias, Hu, Junjie, Liu, Xianqiong, Lu, Xinjun, Song, Xinhua, Su, Tao, Utpatel, Kirsten, Wang, Jingxiao, Wang, Pan, Xu, Meng, Zhang, Jie, Zhang, Yi   +14 more
core   +1 more source