Results 51 to 60 of about 3,225,994 (369)
Metalloproteinases and their inhibitors in tumor angiogenesis [PDF]
International Journal of Cancer, 2005 AbstractAngiogenesis is the process by which new blood vessels are formed from preexisting vasculature. It is an essential feature of the female reproductive cycle, embryonic development and wound repair. Angiogenesis has also been identified as a causal or contributing factor in several pathologies, including cancer, where it is a rate‐limiting step ...
Handsley, M.M., Edwards, D.R.
openaire +4 more sources
MTOR cross-talk in cancer and potential for combination therapy [PDF]
, 2018 The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C. +7 more
core +3 more sources
Journal of Cardiovascular Medicine, 2016 The US National Cancer Institute estimates that cardiotoxicity (CTX) from target therapy refers mostly to four groups of drugs: epidermal growth factor receptor 2 inhibitors, angiogenic inhibitors, directed Abelson murine leukemia viral oncogene homolog ...
N. Maurea +11 more
semanticscholar +1 more source
Irsogladine is a potent inhibitor of angiogenesis [PDF]
FEBS Letters, 1993 We describe a novel inhibitor of angiogenesis, Irsogladine, an anti‐ulcer drug. Irsogladine inhibited plasminogen activator synthesis of, and tube formation by, human microvascular endothelial cells in type 1 collagen gel treated with an angiogenic growth factor, EGF.
Kazuki Okamura +7 more
openaire +3 more sources
Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis [PDF]
, 2016 This is the preprint version of our manuscript, corresponding to the article that has been published in final form at FOOD CHEMISTRY with DOI: 10.1016/j.foodchem.2016.10.111The health benefits of olive oil are attributed to their bioactive compounds ...
García-Vilas, Javier A. +2 more
core +1 more source
Angiogenesis inhibitors for the treatment of small cell lung cancer (SCLC)
Medicine, 2017 Background: This study aimed to assess the effectiveness and safety of angiogenesis inhibitors for the treatment of patients with small cell lung cancer (SCLC) via meta-analysis.
Qing Li +10 more
semanticscholar +1 more source
Acetylcholinesterase inhibitors attenuate angiogenesis [PDF]
Clinical Science, 2012 Donepezil {(RS)-2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one} is a reversible acetylcholinesterase inhibitor and used for treatment of patients with AD (Alzheimer's disease). Recent studies showed that treatment with donepezil reduced production of inflammatory cytokines in PBMCs (peripheral blood mononuclear cells).
Aya Kamiharaguchi +8 more
openaire +3 more sources
PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma-secretase inhibitor [PDF]
, 2019 Ovarian cancer is the fifth leading cause of cancer-related deaths in women. In the past 20 years, the canonical types of drugs used to treat ovarian cancer have not been replaced and the survival rates have not changed.
Abramovich, Dalhia Nurit +7 more
core +1 more source
Recent advances on anti-angiogenesis receptor tyrosine kinase inhibitors in cancer therapy
Journal of Hematology & Oncology, 2019 Angiogenesis has always been the topic of major scientific interest in the field of malignant tumors. Nowadays, targeting angiogenesis has achieved success in various carcinomas by several mechanisms, including the use of anti-angiogenic small molecule ...
Shuang Qin +5 more
semanticscholar +1 more source
Evaluation of Angiogenesis Inhibitors Using the HUVEC Fibrin Bead Sprouting Assay
Bio-Protocol, 2016 Angiogenesis, the growth of new blood vessels from pre-existing vessels, is a critical process that occurs during normal development and tumor formation.
Laura Winters +3 more
doaj +1 more source