Results 81 to 90 of about 3,225,994 (369)
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
The Hemostatic System and Angiogenesis in Malignancy
Neoplasia: An International Journal for Oncology Research, 2001 Coagulopathy and angiogenesis are among the most consistent host responses associated with cancer. These two respective processes, hitherto viewed as distinct, may in fact be functionally inseparable as blood coagulation and fibrinolysis, in their own ...
Marek Z. Wojtukiewicz +3 more
doaj +1 more source
New Advances in Targeted Therapy of HER2-Negative Breast Cancer
Frontiers in Oncology, 2022 Breast cancer has an extremely high incidence in women, and its morbidity and mortality rank first among female tumors. With the increasing development of molecular biology and genomics, molecular targeted therapy has become one of the most active areas ...
Junsha An +4 more
doaj +1 more source
Hepatocellular carcinoma and multidrug resistance: Past, present and new challenges for therapy improvement [PDF]
, 2015 Hepatocellular carcinoma (HCC) is the most common malignancy of the liver and the third cause of cancer death worldwide. Chronic hepatitis due to HBV and HCV infection are two major risk factors for HCC worldwide.
Cuestas, María Luján +2 more
core +1 more source
Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
wiley +1 more source
Circulating levels of matrix proteases and their inhibitors in pregnant women with and without a history of recurrent pregnancy loss [PDF]
, 2010 Background: We have recently shown that serum relaxin-2 levels are attenuated in women with a history of recurrent pregnancy loss (RPL). We sought to determine whether a history of RPL is also associated with changes in serum matrix metalloproteases ...
Anumba, D.O.C. +3 more
core +3 more sources
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Therapeutic Advances in Medical OncologyBackground: Immune checkpoint inhibitors (ICIs) combined with chemotherapy, with or without angiogenesis inhibitors, have been investigated as the first-line treatment for extensive-stage small-cell lung cancer (ES-SCLC).
Linjing Zhou +8 more
doaj +1 more source
RET mutation and increased angiogenesis in medullary thyroid carcinomas [PDF]
, 2016 Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit receptor tyrosine kinases, many of which involved in angiogenesis.
Acquaviva, Giorgia +16 more
core +1 more source
Cancers, 2013 Angiogenesis, the formation of new blood vessels from existing vessels is required for many physiological processes and for growth of solid tumors.
T. Friis +4 more
semanticscholar +1 more source