Results 91 to 100 of about 1,147,332 (293)
Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang +4 more
wiley +1 more source
The impact of angiogenesis inhibitors on survival of patients with small cell lung cancer
Cancer Medicine, 2019 Background Small cell lung cancer (SCLC) is a highly invasive and lethal neuroendocrine tumor. Antiangiogenic drugs have been reported in the treatment of SCLC. We aimed to provide a comprehensive evaluation of the impact of angiogenic inhibitors on SCLC
Xiaoshun Shi +10 more
doaj +1 more source
Pharmaceuticals, 2010 Uncontrolled neovascularization occurs in several angiogenesis-dependent diseases, including cancer. Neovascularization is tightly controlled by the balance between angiogenic growth factors and antiangiogenic agents.
Marco Rusnati +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand +5 more
wiley +1 more source
ФармакоэкономикаBackground. Studies on the pharmaceutical provision of neovascular age-related macular degeneration with angiogenesis inhibitors in the Russian Federation have repeatedly indicated a mismatch between the level of consumption and the actual need for these
F. V. Gorkavenko +8 more
doaj +1 more source
Advanced Functional Materials, EarlyView.A pioneering magnetogenetic toolkit enables non‐invasive, precise spatiotemporal modulation of intracellular Wnt/β‐catenin signaling. Functionalized magnetic nanoparticles (MNPs@E/EC15) target cellular E‐cadherins to generate localized magnetomechanical forces under low‐intensity magnetic fields.
Christian Castro‐Hinojosa +7 more
wiley +1 more source
Epigenetic regulation of angiogenesis and its therapeutics
Genomics & InformaticsAngiogenesis, the formation of new blood vessels from preexisting ones, is essential for normal development, wound healing, and tissue repair. However, dysregulated angiogenesis is implicated in various pathological conditions, including cancer, diabetic
Dong Kyu Choi
doaj +1 more source
Protease‐Activated Theranostic Nanomedicine for Endometriosis Treatment
Advanced Functional Materials, EarlyView.Endometriosis is a chronic gynecological disorder that affects a substantial proportion of reproductive‐aged women. In this study, we identify aberrant overexpression of matrix metalloproteinase‐9 (MMP‐9) in endometriotic lesions and develop a novel multifunctional nanomedicine that integrates MMP‐9‐targeted therapy, ratiometric photoacoustic (PA ...
Panangattukara Prabhakaran Praveen Kumar +9 more
wiley +1 more source
New Angiogenesis Inhibitors from Marine-Derived Actinomycetes
, 2009 Marine microbial natural products continue to represent an important source of novel compounds for the development of new therapeutic agents. As part of our ongoing research to isolate novel angiogenesis inhibitors, we have focused considerable attention
신희재, 이희승, 권호정
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