Results 91 to 100 of about 215,305 (295)
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Clinical application and cardiovascular adverse effects of angiogenesis inhibitors [PDF]
This thesis examines the role that angiogenesis inhibitors play in certain disease conditions and their effects on the cardiovascular system. Vascular endothelial growth factor (VEGF) is one of the most important proangiogenic growth factors, and ...
Olih, Patricia
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Angiogenesis inhibitors in cancer therapeutics [PDF]
, 2017 In the era molecular pharmacology, development of angiogenesis inhibitors is certainly a master discovery .There are specific angiogenesis inhibitors are being used in cancer and various endogenous anti-angiogenesis molecules are discovered .This review ...
Krishnan, V., Sadasivan, Usha
core +1 more source
MicroRNA-145 Regulates Pathological Retinal Angiogenesis by Suppression of TMOD3
Molecular Therapy: Nucleic Acids, 2019 Pathological angiogenesis is a hallmark of various vascular diseases, including vascular eye disorders. Dysregulation of microRNAs (miRNAs), a group of small regulatory RNAs, has been implicated in the regulation of ocular neovascularization.
Chi-Hsiu Liu +4 more
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Angiogenesis inhibitors in cancer treatment [PDF]
, 2017 Tématem bakalářské práce jsou inhibitory angiogeneze v terapii nádorových onemocnění. První část práce se zaměřuje na pojem angiogeneze a nádorová angiogeneze.
Papáčková, Eva
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Models for assessing anti-angiogenesis agents: Appraisal of current techniques [PDF]
, 2017 A number of reproducible, technically satisfactory methods are available for experimentally measuring the anti- and proangiogenic activities of vascular growth factors, hormones, peptides, and pharmaceuticals.
Mousa, Shaker A., Davis, Paul J.
core +1 more source
Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang +4 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand +5 more
wiley +1 more source