Results 21 to 30 of about 99,753 (275)

Complete hematologic response in a patient with multiple pretreated angioimmunoblastic T‐cell lymphoma after belinostat therapy followed by allogeneic stem cell transplantation: A case report [PDF]

Clinical Case Reports
Key Clinical Message Belinostat therapy followed by hematopoietic stem cell transplantation is a promising salvage strategy for heavily pretreated patients with peripheral T‐cell lymphoma.
Sigrid De Wilde, Carlos Graux
doaj   +2 more sources

IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma [PDF]

Blood, 2012
Abstract Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) occur in most grade 2 and 3 gliomas, secondary glioblastomas, and a subset of acute myelogenous leukemias but have not been detected in other tumor types. The mutations occur at specific arginine residues and result in the acquisition of a novel
Cairns, RA, Iqbal, J, Lemonnier, F, Kucuk, C, de Leval, L, Jais, JP, Parrens, M, Martin, A, Xerri, L, Brousset, P, Chan, WC, Gaulard, P, Mak, TW, Chan, LC   +13 more
openaire   +7 more sources

CUTANEOUS MANIFESTATIONS OF ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA

Vestnik Dermatologii i Venerologii, 2018
Background: Angioimmunoblast T-cell lymphoma (AITL) is a rare T-cell lymphoproliferative disease that is accompanied by generalized lymphadenopathy, hepatosplenomegaly, intoxication symptoms and extranodal lesions.
N. G. Chernova, M. N. Sinitsyna, Yu. V. Sidorova, N. P. Soboleva, A. B. Sudarikov, A. M. Kovrigina, V. N. Dvirnyk, E. E. Zvonkov   +7 more
doaj   +3 more sources

A targeted mutational landscape of angioimmunoblastic T-cell lymphoma [PDF]

Blood, 2014
Key Points AITL is characterized by high frequencies of overlapping mutations in epigenetic modifiers, including TET2, IDH2, and DNMT3A. Targetable mutations are present in a subset of cases.
Nancy L. Harris, Julie Teruya-Feldstein, David M. Weinstock, Jonathan H. Schatz, Jonathan H. Schatz, Diederik van Bodegom, Nadja Kopp, Matthew A. Lunning, Sudha Bolla, Pier Paolo Piccaluga, Sunhee Kim, Kristen E. Stevenson, Andrew A. Lane, Ephraim P. Hochberg, Simone Ferrero, Steven M. Horwitz, David M. Dorfman, Dan Toscano, Abner Louissaint, Eric D. Jacobsen, Oreofe O. Odejide, Giorgio Inghirami, Scott J. Rodig, Stefano Pileri, Oliver Weigert, Oliver Weigert   +25 more
openaire   +6 more sources

Burrowing through the heterogeneity: Review of mouse models of PTCL-NOS [PDF]

Frontiers in Oncology, 2016
Currently, there are nineteen different PTCL entities recognized by the World Health Organization; however, approximately 70 percent of PTCL diagnoses fall within one of three subtypes (i.e.
Christine E Cutucache, Tyler Andrew Herek   +1 more
doaj   +4 more sources

How I Diagnose Angioimmunoblastic T-Cell Lymphoma [PDF]

American Journal of Clinical Pathology, 2021
OBJECTIVES Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma derived from T-follicular helper cells. For pathologists, diagnosing AITL may be challenging due to its wide clinical and histopathologic spectrum, which can ...
Yi Xie, Elaine S. Jaffe
openalex   +2 more sources

The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells [PDF]

Blood, 2007
The molecular alterations underlying the pathogenesis of angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma, unspecified (PTCL-u) are largely unknown.
Laurence de Leval, David S. Rickman, Caroline Thielen, Aurélien de Reyniès, Yen‐Lin Huang, Georges Delsol, Laurence Lamant, Karen Leroy, Josette Brière, Thierry Jo Molina, Françoise Berger, Christian Gisselbrecht, Luc Xerri, Philippe Gaulard   +13 more
openalex   +2 more sources

Treatment with 5-azacytidine induces a sustained response in patients with angioimmunoblastic T-cell lymphoma [PDF]

Blood, 2018
TO THE EDITOR: Peripheral T-cell lymphomas (PTCLs) are heterogeneous diseases resulting from the malignant transformation of mature T or natural killer cells.
François Lemonnier, Jehan Dupuis, Pierre Sujobert, Olivier Tournillhac, Morgane Cheminant, Clémentine Sarkozy, Laura Pelletier, Ambroise Marçais, Cyrielle Robe, Virginie Fataccioli, Corinne Haïoun, Olivier Hermine, Philippe Gaulard, Richard Delarue   +13 more
openalex   +2 more sources

Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin

Haematologica, 2017
In addition to angioimmunoblastic T-cell lymphoma (AITL), the 2016 revised WHO classification of haematological malignancies recognizes two provisional lymphoma entities of follicular helper T-cell (TFH) derivation, namely follicular peripheral T-cell ...
Maria Pamela Dobay, François Lemonnier, Edoardo Missiaglia, Christian Bastard, David Vallois, Jean‐Philippe Jaïs, Laurianne Scourzic, Aurélie Dupuy, Virginie Fataccioli, Anaïs Pujals, Marie Parrens, Fabien Le Bras, Thérèse Rousset, Jean‐Michel Picquenot, Nadine Martin, Corinne Haïoun, Richard Delarue, Olivier Bernard, Mauro Delorenzi, Laurence de Leval, Philippe Gaulard   +20 more
openalex   +2 more sources

High CD8⁺tumor-infiltrating lymphocytes indicate severe exhaustion and poor prognosis in angioimmunoblastic T-cell lymphoma. [PDF]

Front Immunol, 2023
Background Exhaustion of CD8+ tumor-infiltrating lymphocytes (TILs), characterized by the overexpression of immune checkpoints (IC), is a major impediment to anti-tumor immunity.
Zhu Q, Yang Y, Deng X, Chao N, Chen Z, Ye Y, Zhang W, Liu W, Zhao S.   +8 more
europepmc   +2 more sources