Results 51 to 60 of about 99,753 (275)

Molecular insights into pathogenesis and targeted therapy of peripheral T cell lymphoma

Experimental Hematology & Oncology, 2020
Peripheral T-cell lymphomas (PTCLs) are biologically and clinically heterogeneous diseases almost all of which are associated with poor outcomes. Recent advances in gene expression profiling that helps in diagnosis and prognostication of different ...
Caiqin Xie, Xian Li, Hui Zeng, Wenbin Qian   +3 more
doaj   +1 more source

Peripheral T-cell lymphoma: Frequency and distribution in a tertiary referral center in South India

Indian Journal of Pathology and Microbiology, 2012
Background and Aim: Peripheral T/NK-cell lymphomas are uncommon types of non-Hodgkin′s lymphoma (NHL) with a higher frequency in Far East countries as compared to the West.
Deepak K Burad, Manipadam M Therese, Sheila Nair   +2 more
doaj   +1 more source

Targeting TET2 as a Therapeutic Approach for Angioimmunoblastic T Cell Lymphoma. [PDF]

Cancers (Basel), 2022
Simple Summary Recent advances in exome sequencing and comprehensive genomic studies have shed new light on the pathogenesis and mutational landscape of Angioimmunoblastic T-cell lymphoma (AITL).
Hu L, Zhang X, Li H, Lin S, Zang S.
europepmc   +2 more sources

Identification of cell-type-specific mutations in nodal T-cell lymphomas [PDF]

, 2017
Recent genetic analysis has identified frequent mutations in ten-eleven translocation 2 (TET2), DNA methyltransferase 3A (DNMT3A), isocitrate dehydrogenase 2 (IDH2) and ras homolog family member A (RHOA) in nodal T-cell lymphomas, including ...
Asabe Y, Chiba K, Chiba S, Izutsu K, Kano J, Matsubara D, Minowa T, Miyano S, Miyoshi H, Nakamura N, Nguyen T B, Noguchi M, Ogawa S, Ohshima K, Sakata-Yanagimoto M, Shiraishi Y, Takeuchi K, Tanaka H, Yoshida K, 加野 准子, 千葉 滋, 坂田（柳元） 麻実子, 野口 雅之   +22 more
core   +1 more source

Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms.

Blood Advances, 2020
TET2 and DNMT3A mutations are frequently identified in T-cell lymphomas of T follicular helper cell origin (TCL-TFH), clonal hematopoiesis (CH), and myeloid neoplasms (MNs). The relationships among these 3 entities, however, are not well understood.
N. Lewis, K. Petrova-Drus, S. Huet, Z. Epstein-Peterson, Qi Gao, Allison Sigler, Jeeyeon Baik, N. Ozkaya, A. Moskowitz, Anita Kumar, S. Horwitz, Yanming Zhang, M. Arcila, R. Levine, M. Roshal, A. Dogan, Wenbin Xiao   +16 more
semanticscholar   +1 more source

3D investigation shows walls and wall-like structures around human germinal centres, probably regulating T- and B-cell entry and exit.

PLoS ONE, 2020
This study deals with 3D laser investigation on the border between the human lymph node T-zone and germinal centre. Only a few T-cells specific for antigen selected B-cells are allowed to enter germinal centres.
Miguel Thomos, Patrick Wurzel, Sonja Scharf, Ina Koch, Martin-Leo Hansmann   +4 more
doaj   +1 more source

Prolonged survival of patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation: the GELTAMO experience [PDF]

, 2007
OBJECTIVES: Angioimmunoblastic T-cell lymphoma (AIL) is a rare lymphoma with a poor prognosis and no standard treatment. Here, we report our experiences with 19 patients treated with high-dose chemotherapy and autologous stem cell transplantation (HDC ...
Albo, C. (Carmen), Arranz, R. (R.), Bendandi, M. (Maurizio), Bergua, J. (J.), Caballero, M.D. (M.D.), Carrera, D. (D,), Cañigral, G. (G.), Conde, E. (Eulogio), Fernandez, P. (Pascual), Gandarillas, M. (M.), Garcia, J. (Juan Carlos), Grupo Español de Linfomas/Trasplante Autólogo de Médula Ósea (GEL-TAMO), Gutierrez, A. (Antonio), Leon, A. (Angel), Moraleda, J. (José), Morales, A. (Alfonso), Ojanguren, J. (Jesús), Ribera, J.M. (José María), Rodriguez, J. (José), Sureda, A. (Anna)   +19 more
core   +1 more source

Regulatory T-Cell Depletion in Angioimmunoblastic T-Cell Lymphoma [PDF]

The American Journal of Pathology, 2010
Angioimmunoblastic T-cell lymphoma (AITL) is the most frequent nodal T-cell lymphoma and is characterized by a polymorphic lymph node infiltrate, various dysimmune disorders, and a poor prognosis. Regulatory T-cells (Treg) play an emerging role in the prognosis of non-Hodgkin B-cell lymphoma and mediate significant autoreactive T-cell suppression.
Olivier Hermine, Olivier Hermine, Marie-Helene Delfau, Teresa Marafioti, Vahid Asnafi, Vahid Asnafi, Danielle Canioni, Philippe Gaulard, Julie Bruneau, Nicole Brousse, Elizabeth Macintyre, Elizabeth Macintyre, Amédée Renand, Nadine Martin-Garcia, Jennifer C. Paterson   +14 more
openaire   +3 more sources

Comprehensive Epstein-Barr Virus Transcriptome by RNA-Sequencing in Angioimmunoblastic T Cell Lymphoma (AITL) and Other Lymphomas

Cancers, 2021
Simple Summary Angioimmunoblastic T cell lymphoma (AITL) is probably the most common peripheral T-cell lymphoma. This pathology, although rare, is more common in Europe than in other regions. This lymphoma has a poor prognosis.
Nader Bayda, V. Tilloy, A. Chaunavel, Racha Bahri, M. Halabi, J. Feuillard, A. Jaccard, S. Ranger-Rogez   +7 more
semanticscholar   +1 more source

Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma

Current Oncology, 2021
Angioimmunoblastic T cell lymphoma (AITL) is a common subtype of mature peripheral T cell lymphoma (PTCL). As per the 2016 World Health Organization classification, AITL is now considered as a subtype of nodal T cell lymphoma with follicular helper T ...
M. M. Mohammed Saleh, A. Kotb, Ghada E M Abdallah, I. Muhsen, Riad El Fakih, M. Aljurf   +5 more
semanticscholar   +1 more source