Results 61 to 70 of about 75,735 (193)

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Acute-phase protein alpha1-antitrypsin--a novel regulator of angiopoietin-like protein 4 transcription and secretion

, 2014
Item does not contain fulltextThe angiopoietin-like protein 4 (angptl4, also known as peroxisome proliferator-activated receptor [PPAR]gamma-induced angiopoietin-related protein) is a multifunctional protein associated with acute-phase response.
Marcondes, A.M., Deeg, H.J., Welte, T., Mahadeva, R., Dinarello, C.A., Wrenger, S., Janciauskiene, S., Immenschuh, S., Koczulla, R., Frenzel, E.   +9 more
core   +1 more source

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase

Journal of Lipid Research, 2002
Studies with KK/San, obese and diabetic model mice having a unique hypotriglyceridemia phenotype, revealed that angiopoietin-like protein 3 (ANGPTL3) regulates lipid metabolism in mice.
Kenichi Yoshida, Tetsuya Shimizugawa, Mitsuru Ono, Hidehiko Furukawa   +3 more
doaj   +1 more source

Kaposiform hemangioendothelioma: Diagnosis and treatment

Pediatric Investigation, EarlyView.
Vascular endothelial growth factor‐C (VEGF‐C)/vascular endothelial growth factor receptor‐3 (VEGFR‐3) and angiopoietin‐2 (Ang‐2)/tyrosine kinase with immunoglobulin‐like and EGF‐like domain 2 (TIE2) signaling pathways play an important role in lymphangiogenesis.
Yi Tian, Yuanyuan Tian, Li Wei, Zigang Xu, Li Li, Lin Ma   +5 more
wiley   +1 more source

Angiopoietin-like protein and lipid metabolism

, 2009
Lipoprotein lipase, hepatic lipase, and endothelial lipase play a pivotal role in the clearance and remodelling of plasma lipoproteins. Their activity is governed at the level of gene transcription as well as via changes in enzyme activity by specific ...
Kersten, A.H.
core   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease

, 2010
Objective—To investigate the relationship between angiopoietin-like protein 4 (Angptl4) levels, coronary heart disease (CHD) biomarkers, and ANGPTL4 variants.
Braund, Peter S., Kumari, Meena, Hall, Alistair S., Samani, Nilesh J., Smart-Halajko, Melissa C., Kay-tee Khaw, Steve E. Humphries, Mika Kivimaki, Nilesh J. Samani, Kivimaki, Mika, Boekholdt, S. Matthijs, Marius R. Robciuc, Christopher P. Nelson, Alistair S. Hall, Nelson, Christopher P., Jackie A. Cooper, Meena Kumari, Melissa C. Smart-halajko, Khaw, Kay-Tee, Nicholas J. Wareham, Tom R. Gaunt, Gaunt, Tom R., Khaw, Kay Tee, Peter S. Braund, Ehnholm, Christian, S. Matthijs Boekholdt, Wareham, Nicholas J., Philippa J. Talmud, Jauhiainen, Matti, Matti Jauhiainen, Day, Ian N., Robciuc, Marius R., Talmud, Philippa J., Humphries, Steve E., Cooper, Jackie A., Christian Ehnholm, Ian N. Day   +36 more
core   +1 more source

ANGPT2 Drives Thyroid Cancer Progression Through PI3K/AKT Signaling and Correlates With Poor Prognosis and Immune Infiltration

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives Angiopoietin‐2 (ANGPT2) is known to participate in tumor progression and immune modulation across multiple malignancies. Nevertheless, its expression pattern, prognostic value, and biological function in thyroid cancer (THCA) have not been comprehensively investigated.
Han Chen, Lin Wang, Ji‐Sheng Zhang, Xu‐Dong Yan, Long‐Gang Yu, Yan Jiang   +5 more
wiley   +1 more source

Angiopoietin-like4 can be used to evaluate and predict efficacy for membranous nephropathy

Linchuang shenzangbing zazhi, 2019
Objective To investigate the feasibility of serum and urine angiopoietin-like 4(Angptl4) for evaluating and predicting efficacy for membranous nephropathy.
WANG Jian, NING Li, WANG Run-xiu, CAO Feng   +3 more
doaj