Results 81 to 90 of about 20,336,744 (217)

Angiopoietin-2 and platelet-derived growth-BB factor cooperatively affect peripheral blood monocyte fibrinolysis [PDF]

, 2007
Includes bibliographical ...
Bezuidenhout, Louise
core   +1 more source

Serum angiopoietin-like protein 4 as a predictor of hemorrhagic transformation post-endovascular therapy in acute ischemic stroke: A prospective study.

Journal of the Formosan Medical Association = Taiwan yi zhi
BACKGROUND AND PURPOSE Hemorrhagic transformation (HT) is a major complication after endovascular therapy (EVT) for acute ischemic stroke (AIS), closely associated with blood-brain barrier (BBB) disruption.
Fang Guo, Yanqin Zeng, Xuan-qiang Tu, Jiaqian Dai, Wen-Juan Lin, Liying Pan, Chong Zheng   +6 more
semanticscholar   +1 more source

Knockdown of Angiopoietin-like protein 4 suppresses the development of colorectal cancer.

Cellular and Molecular Biology, 2020
Colorectal cancer, is the growth of cancer cells in the part of the colon. Angiopeptin is one of the growth factors in the human body that is particularly effective in the regulatory process.
Li-Qiang Wen, Yu-chao Zhang, Bin Yang, F. Han, A. Ebadi, Mohsen Toughani   +5 more
semanticscholar   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats

, 2003
Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) have been identified as ligands with different effector functions of the vascular assembly and maturation-mediating receptor tyrosine kinase Tie-2.
Weiss, C, Koblizek, T., Marme, D., Augustin, HG, Augustin, H. G., Fiedler, U, Krissl, T., Martiny-Baron, G., Krissl, T, Koidl, S., Martiny-Baron, G, Deutsch, U, Fiedler, U., Weiss, C., Deutsch, U., Koidl, S, Koblizek, T, Marmé, D   +17 more
core   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Method for decreasing blood glucose and improving glucose tolerance using angiopoietin-like protein 4 [PDF]

, 2008
Angiopoietin like protein 4 is a novel circulating protein predominantly expressed in adipose tissue and liver. Several recent studies demonstrated that angiopoietin like protein 4 is the target gene of peroxisome proliferation activators, the agonists ...

core  

Gene expression in skeletal muscle after an acute intravenous GH bolus in human subjects: identification of a mechanism regulating ANGPTL4

Journal of Lipid Research, 2013
Growth hormone (GH) acutely stimulates lipolysis and fat oxidation, a process that operates postabsorptively and involves activation of the JAK-STAT pathway in the target tissue; no in vivo data exist regarding subsequent GH-regulated gene transcription.
Berthil F.F. Clasen, Thomas Krusenstjerna-Hafstr⊘m, Mikkel Holm Vendelbo, Kasper Thorsen, Carlos Escande, Niels M⊘ller, Steen B. Pedersen, Jens Otto L. J⊘rgensen, Niels Jessen   +8 more
doaj   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source