Results 101 to 110 of about 75,735 (193)

Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover [PDF]

, 2017
Angiopoietin-like 4 (ANGPTL4) is a secreted signaling protein that is implicated in cardiovascular disease, metabolic disorder, and cancer. Outside of its role in lipid metabolism, ANGPTL4 signaling remains poorly understood. Here, we identify ANGPTL4 as
Colozza, Gabriele, Chang, Ling-Shih,, Maria D.J. Benitez, Niehrs, Christof, Christine Dolde, Ling-Shih Chang, Kirsch, Nadine,, Dolde, Christine,, Gabriele Colozza, Andrey Glinka, Christof Niehrs, Benitez, Maria D. J.,, Dolde, Christine, Niehrs, Christof,, Benitez, Maria DJ, Stefan Koch, Colozza, Gabriele,, Glinka, Andrey, Koch, Stefan,, De Robertis, Edward M, Koch, Stefan, Edward M. De Robertis, Kirsch, Nadine, Chang, Ling-Shih, Nadine Kirsch, Glinka, Andrey,, De Robertis, Edward M.,   +26 more
core   +1 more source

Histopathological investigation of wound healing activities of Lucilia sericata Larva and Achillea sintenisii extract combinations in diabetic rat wound model

Medical and Veterinary Entomology, EarlyView.
Lucilia sericata larvae secrete bioactive compounds that promote wound debridement and antimicrobial defence in chronic tissue injuries. Achillea sintenisii extract offers phytotherapeutic support, enhancing healing through anti‐inflammatory and regenerative properties. Diabetic Wistar rats were treated topically with Furacin®, larval secretions, plant
Nevra Polat, Salih Mollahaliloğlu, Murat Koç   +2 more
wiley   +1 more source

Angiopoietin-like protein 4/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity. [PDF]

Proc Natl Acad Sci U S A, 2023
Zhen EY, Chen YQ, Russell AM, Ehsani M, Siegel RW, Qian Y, Konrad RJ.   +6 more
europepmc   +1 more source

Does angiopoietin-like protein 4 (ANGPTL4) plays a role in apoptosis?

, 2008
Anoikis is apoptosis induced by the loss of cell adhesion, which is involved in tissue homeostatsis, wound repair and cancer metastasis. It has been shown that the expression of Fasting Induced Adipose Factor (FIAF), also known as angiopoietin-like ...
Lin, Jiayi
core  

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Angiopoietin-like Protein 4 Inhibition of Lipoprotein Lipase: EVIDENCE FOR REVERSIBLE COMPLEX FORMATION

, 2013
Elevated triglycerides are associated with an increased risk of cardiovascular disease, and lipoprotein lipase (LPL) is the rate-limiting enzyme for the hydrolysis of triglycerides from circulating lipoproteins. The N-terminal domain of angiopoietin-like
Neher, Saskia B., Erie, Dorothy A., Bradford, Kira C., Lafferty, Michael J.   +3 more
core   +1 more source

Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou, Paschalis Karakasis, Panagiotis Theofilis, Konstantinos Pamporis, Panayotis K. Vlachakis, Anastasios Apostolos, Nikolaos Ktenopoulos, Barbara Fyntanidou, Efstratios Karagiannidis, Dimitrios Patoulias, Antonios P Antoniadis, Nikolaos Fragakis   +11 more
wiley   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

The effect of hypoxia and the hypoxia mimetic agent L-mimosine on the production of angiopoietin-like 4 in fibroblasts of the gingiva and the periodontal ligament

, 2017
Einleitung: In der Zahnheilkunde stellt die Entwicklung von parodontalen Erkrankungen ein akutes Problem dar. Um unsere Kenntnisse über die Ätiologie und Therapie parodontaler Erkrankungen zu erweitern, ist ein umfassenderes Verständnis der Auswirkungen ...
Schellner, Alwina
core  

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source